Pravastatin vs. Lipitor: Misiyano, kufanana, uye izvo zviri nani kwauri
Zvinodhaka Vs. ShamwariKuongorora kwezvinodhaka & misiyano mikuru | Conditions kurapwa | Kubudirira | Inishuwarenzi kufukidza uye mutengo kuenzanisa | Zvimwe zvinokanganisa | Kubatana kwezvinodhaka | Yambiro | MIBVUNZO
Pravastatin uye Lipitor (atorvastatin) mishonga yemishonga inoshandiswa kurapa cholesterol yakawanda. Cholesterol mazinga akakwirisa kupfuura zvakajairwa anogona kuwedzera njodzi yehosha yemwoyo, chirwere chevascular, chirwere chemwoyo, uye sitiroko. Cholesterol inonyanya kugadzirwa muchiropa kuburikidza neiyo HMG-CoA reductase enzyme.
Pravastatin uye atorvastatin mishonga inorondedzerwa seHMG-CoA reductase inhibitors. Iyo inozivikanwawo se statin zvinodhaka, pravastatin uye atorvastatin inhibit, kana block, iyo HMG-CoA reductase enzyme, iyo inotungamira kudzikira kwekugadzirwa kwecholesterol muropa. Iko kushandiswa kwema statins kunowedzerawo huwandu hweLDL (low-density lipoprotein) receptors muropa, iyo inobatsira kudzikisa mwero weLDL, kana rudzi rwakaipa rwecholesterol, muropa.
Ose ma pravastatin uye atorvastatin anoshanda nenzira dzakafanana, asi vane misiyano yekuziva nezvayo.
Ndeupi mutsauko mukuru pakati pepravastatin neLipitor?
Pravastatin izita rakajairika raPravachol. Kusiyana nemamwe madhiraini emishonga, pravastatin haina kunyanya kugadziriswa, kana kugadziriswa, neCYP3A4 enzymes muchiropa. Pane kudaro, pravastatin iri yakaputsika mudumbu .
Pravastatin mahwendefa akajairwa anowanikwa musimba re10 mg, 20 mg, 40 mg, uye 80 mg. Pravastatin inowanzo gadzirirwa kutorwa kamwe zuva nezuva manheru. Izvo zvakaratidzwa kuti pravastatin inoshanda zvakanyanya painotorwa manheru pane mangwanani.
Lipitor izita-zita mushonga uye rinowanikwa mune generic vhezheni inonzi atorvastatin. Kusiyana nepravastatin, atorvastatin inogadziriswa zvakanyanya neCYP3A4 enzyme iri muchiropa. Naizvozvo, atorvastatin inogona kusangana nemimwe mishonga kupfuura pravastatin.
Lipitor inowanikwa mumatafura emuromo nemasimba e10 mg, 20 mg, 40 mg, uye 80 mg. Lipitor inogona kutorwa mangwanani kana manheru, uye inowanzo kutorwa kamwe chete zuva nezuva.
| Misiyano mikuru pakati pepravastatin uye Lipitor | ||
|---|---|---|
| Pravastatin | Lipitor | |
| Kirasi yemishonga | HMG-CoA reductase inhibitor | HMG-CoA reductase inhibitor |
| Brand / generic chinzvimbo | Brand uye generic vhezheni iripo | Brand uye generic vhezheni iripo |
| Chii chinonzi generic zita? Chii chinonzi zita rechiratidzo? | Zita reBrand: Pravachol Zita reGeneral: Pravastatin | Brand zita: Lipitor Zita reGeneral: Atorvastatin |
| Ndeapi mafomu (s) ayo mushonga unouya? | Hwendefa remuromo | Hwendefa remuromo |
| Ndeipi muyero wakajairwa? | 10 kusvika 80 mg kamwe pazuva | 10 kusvika 80 mg kamwe pazuva |
| Inguva yakareba sei kurapwa kwacho? | Nguva refu | Nguva refu |
| Ndiani anowanzoshandisa mushonga? | Vakuru; vana nevachiri kuyaruka vane makore masere kusvika gumi nemasere ekuberekwa | Vakuru; vana nevachiri kuyaruka vane makore gumi kusvika gumi nemanomwe |
Mamiriro ezvinhu anorapwa nepravastatin uye Lipitor
Pravastatin uye atorvastatin inogona kubatsira kudzikisa njodzi yekurwadziwa kwemoyo uye kurohwa muvanhu vane chirwere chemwoyo checoronary. Mishonga yese iyi inogona kubatsirawo kudzikisa njodzi yekufa kubva chirwere chemoyo . Njodzi dzinokonzera chirwere chemoyo dzinosanganisira kuwedzerwa kweropa, kuputa, uye huwandu hwecholesterol.
Ose ma pravastatin uye atorvastatin ari FDA anotenderwa kudzora yakakwidziridzwa yakazara-cholesterol uye LDL nhanho (inozivikanwawo se hyperlipidemia kana hypercholesterolemia). Statin mishonga inogona zvakare kubatsira kubata akakwirisa mazinga e triglycerides , iyo iri imwe mhando yemafuta kana lipids mumuviri. Mumwe munhu ane mwero wakakwira we triglycerides ane hypertriglyceridemia.
Pravastatin uye Lipitor zvinogona zvakare kuwedzera HDL mazinga muropa. HDL cholesterol ndiyo inozivikanwa seye cholesterol yakanaka muropa.
| Mamiriro | Pravastatin | Lipitor |
| Hyperlipidemia | Ehe | Ehe |
| Hypercholesterolemia | Ehe | Ehe |
| Hypertriglyceridemia | Ehe | Ehe |
Pravastatin kana Lipitor inoshanda zvakanyanya here?
Ose ma pravastatin uye atorvastatin mishonga inoshanda yekurapa yakakwira ropa cholesterol. Mushonga unoshanda zvakanyanya kunoenderana neako mamiriro ezvinhu, kuomarara kwemamiriro ako, zvimwe zvinodhaka zvaungave uchitora, uye zvimwe zvinhu.
Poshi kuenzanisa kudzidza vakawana kuti hapana musiyano wakakura pakati pepravastatin, simvastatin, uye atorvastatin yekudzivirira zviitiko zvemoyo. Mune mamwe mazwi, aya madhimoni madhimoni aive akafanana mukudzora kurwisa kwemoyo uye chirwere chemwoyo checoronary.
TO kuongorora kwakarongeka iyo yakaunganidzwa pamusoro pemakumi mapfumbamwe emakiriniki ekuedzwa akaenzanisa statin zvinodhaka senge fluvastatin, atorvastatin, pravastatin, simvastatin, uye rosuvastatin. Ongororo iyi yakapedzisa kuti atorvastatin, fluvastatin, uye simvastatin yaive nemukana wakanyanya wekurapa kwakanyanya kudzivirira zviitiko zvemoyo.
Bvunza mupi wezvehutano kuti uone yakanakisa statin mushonga iwe. Mushure mekuitisa ongororo yeropa uye kuongorora mamiriro ako ehupamhi, mupi achakwanisa kuona kana pravastatin kana atorvastatin iri mushonga unoshanda zvakanyanya kwauri. Vanogona zvakare kunyorera chakasiyana statin chinodhaka senge Zocor (simvastatin) kana Crestor (rosuvastatin).
Kuvhavha uye mutengo kuenzanisa kwepavastatin vs. Lipitor
Pravastatin imishonga inowanzoitwa inowanzovharwa neMedare uye zvirongwa zveinishuwarenzi. Mari yepakati yemari yepravastatin yakatenderedza $ 129.99 yemazuva makumi matatu. Kadhi reSingleCare rekuchengetedza rinogona kudzikisira mutengo wepravastatin mushonga kusvika pasi pe $ 15.
Lipitor izita remazita-zita remishonga iro rinowanikwawo mune yakachipa, generic vhezheni. Iyo generic vhezheni yeLipitor, atorvastatin, inowanzo kuvharwa neakawanda maMedare uye zvirongwa zveinishuwarenzi. Brand-zita Lipitor rinogona kuvharwa nehurongwa hweinishuwarenzi ine yakakwira copay. Mutengo wemari weLipitor wakakomberedza $ 249.99. SingleCare makuponi anogona kudzikisa mutengo kusvika pamadhora gumi nemashanu kuma Pharmacies ari kutora chikamu.
| Pravastatin | Lipitor | |
| Kazhinji yakafukidzwa neinishuwarenzi? | Ehe | Ehe |
| Inowanzo kufukidzwa neMedare Chikamu D? | Ehe | Ehe |
| Zvakawanda | Mahwendefa makumi matatu (40 mg) | Mahwendefa makumi matatu (40 mg) |
| Chaizvoizvo Medicare copay | $ 0– $ 20 | $ 0– $ 16 |
| SingleCare mutengo | $ 12 + | $ 15 + |
Zvakajairika mhedzisiro mhedzisiro yepravastatin vs. Lipitor
Mhedzisiro inowanzoitika yepravastatin masculoskeletal kana kurwadziwa kwemhasuru, kuda kurutsa, kurutsa, manyoka, uye musoro. Mhedzisiro inowanzoitika yeatorvastatin ndeye musculoskeletal kana kurwadziwa kwemhasuru, manyoka, uye kurwadziwa kwekubatana (arthralgia). Zvese pravastatin uye atorvastatin zvinogona zvakare kukonzera mamwe mhedzisiro senge indigestion, dzungu, kuneta, mapundu, uye weti turakiti hutachiona.
Zvakakomba mhedzisiro yemishonga yemastin inosanganisira chirwere chetsandanyama (myopathy) uye nekukurumidza kuparara kwemasuru nyama (rhabdomyolysis). Bata mupi wezvehutano nekukurumidza kana iwe uchinge uchinge uchirarama kana kusatsanangudzwa kurwadziwa kwemhasuru, kushaya simba, kana hunyoro.
Pravastatin uye atorvastatin zvinogona zvakare kukonzera maenzymes eropa akasimba. Chiropa enzyme mazinga angangoda kuongororwa pamberi uye kuongororwa mukati mekurapa.
| Pravastatin | Lipitor | |||
| Side maitiro | Zvinoshanda? | Kakawanda | Zvinoshanda? | Kakawanda |
| Musculoskeletal kurwadziwa | Ehe | 10% | Ehe | 4% |
| Kushungurudzika / kurutsa | Ehe | 7% | Ehe | 4% |
| Manyoka | Ehe | 7% | Ehe | 7% |
| Kuzvidya mwoyo | Ehe | 3% | Ehe | 5% |
| Dzungu | Ehe | 4% | Ehe | * |
| Kutemwa nemusoro | Ehe | 6% | Kwete | - |
| Kuneta | Ehe | 3% | Ehe | * |
| Mapundu | Ehe | 5% | Ehe | * |
| Arthralgia | Ehe | * | Ehe | 7% |
| Urinary turakiti hutachiona | Ehe | 3% | Ehe | 6% |
Kakawanda hakubvi pane data kubva kumusoro-kuenda-kumusoro kutongwa. Izvi zvinogona kunge zvisiri rondedzero izere yemhedzisiro mhedzisiro inogona kuitika. Ndokumbira utarise kuna chiremba wako kana mupi wezvehutano kuti udzidze zvimwe.
Kwayaka: DailyMed ( Pravastatin ), Zuva Nezuva ( Lipitor )
* haina kutaurwa
Kubatana kwezvinodhaka zvepravastatin vs. Lipitor
Pravastatin uye atorvastatin vanobatana nemishonga yakafanana. Nekudaro, sezvo atorvastatin inogadziriswa zvakanyanya neiyo CYP3A4 enzyme iri muchiropa, inogona kusangana nemimwe mishonga inokanganisa iyo CYP3A4 enzymes muchiropa.
Kutora mishonga senge cyclosporine, clarithromycin, kana ritonavir ine pravastatin kana atorvastatin kunogona kutungamira kuwanda kwemasitini muropa, izvo zvinogona kuwedzera njodzi yemhedzisiro.
Maantacid anogona kukanganisa kupinza kwemasermin mishonga uye nekudzora kushanda kwawo. Iko manejimendi emaantacid uye statins inofanirwa kupatsanurwa nemaawa maviri. Cholestyramine inogona zvakare kudzikisa kunwa uye kushanda kwema statins. Iko manejimendi echolestyramine uye statins inofanirwa kupatsanurwa nemaawa mana.
Niacin uye fibrate zvinogona kuwedzera njodzi yeiyo myopathy uye rhabdomyolysis painotorwa pamwe nepravastatin kana atorvastatin.
Iko kushandiswa kweatorvastatin kunofanirwa kudzivirirwa kana kuongororwa kana uchidya muto wemazambiringa . Grapefruit muto unoshanda seCYP3A4 inhibitor iyo inogona kutungamira kumatanho ekuwedzera eatorvastatin muropa uye kuwedzera njodzi yemhedzisiro.
| Zvinodhaka | Kirasi yemishonga | Pravastatin | Lipitor |
| Cyclosporine | Immunosuppressants | Ehe | Ehe |
| Clarithromycin Erythromycin | Mishonga inorwisa mabhakitiriya | Ehe | Ehe |
| Ketoconazole Itraconazole Voriconazole Posaconazole | Antifungals | Kwete | Ehe |
| Ritonavir Simeprevir Ledipasvir Boceprevir Darunavir | Mishonga inorwisa utachiona | Ehe | Ehe |
| Niacin | Antilipemic vamiririri | Ehe | Ehe |
| Fenofibrate Gemfibrozil | Fibrates | Ehe | Ehe |
| Digoxin | Cardiac glycosides | Ehe | Ehe |
| Cholestyramine | Bheri asidhi sequestrants | Ehe | Ehe |
| Aluminium hydroxide Magnesium hydroxide | Antacids | Ehe | Ehe |
Bvunza nyanzvi yezvehutano kune kumwe kudyidzana kwezvinodhaka.
Yambiro dzepravastatin uye Lipitor
Pravastatin uye atorvastatin inofanirwa kudzivirirwa kune avo vane chirwere chechiropa chinoshanda kana mazinga enzyme akanyanya echiropa. Statin mishonga inogona kukonzera kumwe kukuvara kwechiropa mune mumwe munhu ane chirwere chechiropa.
Pravastatin uye atorvastatin haifanire kushandiswa kune avo vane nhoroondo ye hypersensitivity reaction kune statin mishonga. Zviratidzo uye zviratidzo zveiyo hypersensitivity reaction zvinosanganisira kuputika, kuchenesa, kuzvimba, uye kunetseka kufema.
Mishonga yeStatin inotakura njodzi yekukuvara kwakanyanya kwemhasuru uye kurwadziwa kwemhasuru. Panogona kuve nenjodzi yakawedzera yekurwadziwa kwemhasuru kune avo vanopfuura makore makumi matanhatu nemashanu ekuberekwa kana vasina kudzora hypothyroidism kana matambudziko eitsvo.
Pravastatin uye atorvastatin haifanire kushandiswa kune avo vane pamuviri kana kuyamwa.
Taura nemubatsiri wezvehutano kuti utaure nezve zvimwe zvinogona kunyeverwa kana zvidziviriro zvine chekuita nepravastatin kana atorvastatin.
Inowanzo bvunzwa mibvunzo nezve pravastatin vs. Lipitor
Chii chinonzi pravastatin?
Pravastatin imushonga wakajairika unoshandiswa kudzikisa cholesterol uye kudzivirira matambudziko anokonzerwa necholesterol yakakwira. Iro zita rekuti pravastatin ndiPravachol. Iyo inorayirwa kutorwa kamwe chete zuva nezuva manheru. Pravastatin inowanikwa sehwendefa remuromo.
Chii chinonzi Lipitor?
Lipitor izita-zita mishonga inogadzirwa naPfizer. Iro generic zita reLipitor ndeye atorvastatin. Iyo inoshandiswa kurapa yakakwira cholesterol mazinga uye kudzikisa njodzi yekurwadziwa kwemoyo uye sitiroko. Lipitor inorayirwa kutorwa kamwe chete zuva nezuva mangwanani kana manheru. Inowanikwa sehwendefa remuromo.
Pravastatin uye Lipitor zvakafanana here?
Ose ma pravastatin uye atorvastatin mishonga inoshandiswa kudzikisa huwandu hwecholesterol. Zvisinei, ivo havana kufanana. Atorvastatin inonyanya kugadziriswa neCYP P450 enzyme system muchiropa nepo pravastatin yakatyoka mudumbu. Pravastatin inowanzo kutorwa husiku apo Lipitor inotorwa mangwanani kana manheru.
Pravastatin kana Lipitor iri nani here?
Ose ma pravastatin uye Lipitor ndiwo anoshanda mafomu e statin therapy. Ose ari maviri mishonga anogona kubatsira kudzivirira kunetseka kweakakwira cholesterol mazinga, senge atherosclerosis, chirwere chemwoyo, uye sitiroko. Zvimwe zvidzidzo kubva cardiology magazini vawana kuti atorvastatin, chinhu chinoshanda muLipitor, chinoshanda kupfuura mamwe madhiragi emishonga ekudzivirira zviitiko zvemwoyo senge kurwisa kwemoyo uye sitiroko. Anopa hutano anogona kupa kuraira kwekurapa pane yakanakisa statin mishonga yako.
Ndinogona here kushandisa pravastatin kana Lipitor ndichiri nepamuviri?
Pravastatin uye atorvastatin hazvikurudzirwe kutorwa uine nhumbu. Mishonga yese iri miviri ine njodzi huru yekukonzeresa hurema hwekuzvara. Bvunza mupi wezvehutano kuti akutungamire pakurapwa kwakanyanya kwecholesterol yakakura uine pamuviri.
Ndinogona here kushandisa pravastatin kana Lipitor nedoro?
Iko hakuna yakakosha njodzi yehutano inosanganisirwa zvine mwero kunwa doro uye statins. Statin zvinodhaka uye kunyanyisa kunwa doro inogona kukuvadza chiropa . Taura nemubatsiri wezvehutano kuti uone kana zvakachengeteka kuti iwe unwe doro uchitora mushonga wesitinin.
