Iyo ina inokwanisika mhedzisiro mhedzisiro ye statins (uye maitiro ekuvarwisa)

Zvinodhaka Info

Zvinogona kuita kunge cholesterol yakakwira hachisi chinhu hombe-mushure mezvose, vanopfuura mamirioni 102 emamerica ane makore anopfuura makumi maviri vane huwandu hwakazara hwecholesterol hwapfuura huwandu hwakajairika (200 mg / dL), maererano Nzvimbo dzeDziviriro Kudzora uye Kudzivirira (CDC). Zvakatonyanya, mamirioni makumi matatu nemashanu evakuru vacho vane mazana e240 mg / dL kana yakakwira, izvo zvinovaisa munzvimbo ine njodzi yekuvandudza chirwere chemwoyo. Kungoita nekuti zvakajairika, hazvireve kuti unogona kuzvisiya kana zvako zvikayera pamusoro pezvikamu zvine hutano. Izvo zvakakosha kuti unzwisise uye utore cholesterol yako-inogona nekushandisa kurapwa senge statins.

Chii chinonzi cholesterol?

Cholesterol chinhu chine waxy chinouya kubva muchiropa (muviri unozvigadzira) uye kubva kuchikafu chako (chinowanikwa mune zvekudya zvemhuka, senge nyama, mazai, uye mukaka wakazara wemafuta). Cholesterol inotenderera kuburikidza neropa uye inodikanwa kune akati wandei mashandiro emuviri, kusanganisira kugadzirwa kwehomoni, vhitamini D, uye membrane yesero. Zvisinei, kuwandisa kwecholesterol muropa — inonzi low-density lipoprotein kana LDL cholesterol — inogona kunamatira kumadziro etsinga ikashanduka kuita plaque.

Plaque mune yedu arteri inogona kuvhara kuyerera kweropa uye kusimudzira kugadzirwa kwegadziriro, izvo zvinotungamira kukuvadzwa kwemoyo (semuenzaniso, chirwere chemwoyo) uye kukuvara kwehuropi (sitiroko), anodaro Joshua Yamamoto, MD, chiremba wezvemwoyo, mubatsiri weFoxhall Medicine muWashington , DC, uye munyori we Unogona Kudzivirira Sitiroko . Muchokwadi, kukura kwemarara hachisi chirwere [chinonzi hypercholesterolemia] -i biology yechisikigo, mhedzisiro yenguva nezera pakutenderera kwedu.

Chii chinonzi statins?

Statins, kirasi yemishonga inoderedza cholesterol, yave muyero wegoridhe pakurapa hypercholesterolemia, inotsanangura Chiremba Jennifer Haythe, MD , chiremba wezvemwoyo kuNewYork-Presbyterian / Columbia University Irving Medical Center. Muchokwadi, vanopfuura mamirioni e11,6 vanhu vakuru veAmerica parizvino vari kutora mishonga ye statin yeatherosclerotic yemwoyo chirwere (ASCVD), zvinoenderana nehuwandu kubva kune ichangoburwa National Hutano uye Kudya Kwekuongorora Ongororo .

Akakurumbira masisitimu anosanganisira:

• Crestor (rosuvastatin)
• Lipitor (atorvastatin)
• Zocor (simvastatin)
• Pravachol (pravastatin)
• Altoprev kana Mevacor (lovastatin)
• Lescol (fluvastatin)
• Livalo (pitavastatin)

Ma statins anoshanda sei?

Statins inoshanda nekungovhara iyo enzyme inogadzira cholesterol, asi zvakare nekubatsira muviri kudzoreredza iripo cholesterol, Dr. Haythe anotsanangura. Dr. Yamamoto vanowedzera kuti mateminiki anofanirwa kufungidzirwa semishonga inodzivirira yevascular sezvo ma meds ane kugona kudzivirira tsinga, kudzivirira kukura kweplate, uye - zvakanyanya kukosha - kudzivirira kurwara kwemoyo, sitiroko, kukuvara kwehuropi, uye kufa nguva isati yakwana.

Zvimwe zvinokanganisa zve statins

Uye nepo zvakajairika uye zvichitenderwa neKudya neDrug Administration (FDA), maitiro anogona kuitika nguva nenguva kubva mukushandiswa kwema statins. (Ongororo yaDecember 2018 yakaburitswa ne American Moyo Sangano akataura kuti mhedzisiro yematemu haishoma-uye kuti mabhenefiti anokunda njodzi.) Heano mikana yemhedzisiro yemastatins:

1. Aches uye kurwadziwa

Vese varapi vatakataura kuti vabvumirane kuti marwadzo uye mhasuru marwadzo (anonziwo myalgia) ndiyo nhamba yekutanga kunyunyuta kubva kuvarwere, iine chero pakati pe4% ne10% yevanhu vari kubatwa. Izvo zvakakosha kuti uzive kuti 1 mu20 vedu tinokombamira kukudziridza nyore nyore mhasuru aches, Dr. Yamamoto anowedzera.

Dzimwe nzira dzekuchinja mararamiro dzinogona kubatsira kudzikira kwenjodzi yemyop uye kukuvara kwemhasuru, kusanganisira kudzikamisa kurovedza muviri zvine simba (sezvo kusimba kwekurovedza muviri kunogona kuisa kushushikana pamhasuru dzakatotsva) uye kutora coenzyme Q10 chikafu chinowedzera.

Dr. Yamamoto vanoti nekuda kwekuti CoQ10 inogadzirwa mumhasuru, statin therapy inogona kuibvisa kubva muchirongwa, zvichikonzera kusuruvara kwemhasuru. Vegans inowanzo kuve yakanyanya kutetepa kune aches nemarwadzo ane chekuita nekushandisa statin sezvo CoQ10 inowanzo kuwanikwa munyama tsvuku, anodaro. Asi ramba uchifunga kuti kuve vegan hakuna nzira kunotidzivirira kubva pamhedzisiro yenguva, uye chikonzero chinotungamira cherufu kune vegans ichiri chirwere chemoyo.

2. Yakawanda shuga yeropa

Statins inogona zvakare kuwedzera shuga zveropa mukati mevanhu vane metabolic syndrome, pre-chirwere cheshuga kana muganho weropa mashuga eropa, Dr. Haythe anotsanangura. Chidzidzo che2017 chakabudiswa mumagazini BMJ Vhura Chirwere cheshuga Tsvagiridzo & Kuchengeta yakacherekedza kuti zvimisikidzo zvaive zvakabatana nemitengo yakakwira zvakanyanya yechirwere cheshuga muvarwere vaive panjodzi huru yekuvandudza mhando yechirwere cheshuga

3. Yakakwidziridzwa enzyme yechiropa

Vamwe varwere vanozoona chiropa kuzvimba kubva pakutora statins, sekureva Iyo Mayo Clinic . Asi huwandu hwacho hudiki-chinyorwa chakaburitswa muchinyorwa cha2013 chemagazini Gastroenterology & Hepatology inoti kiriniki miedzo inoratidza kuti statins dzakabatanidzwa nekukwirisa mu serum alanine aminotransferase (ALT, enzyme inowanikwa kunyanya muchiropa neitsvo) muavhareji ye3 muzana yevarwere.

Zviratidzo zvekukuvara kwechiropa zvinosanganisira kuneta zvakanyanya, kurasikirwa nechido, kurwadziwa mumuviri wepamusoro, weti yakasviba muvara, uye / kana yero yeganda kana maziso. Kana iyo enzyme yechiropa ichiwedzera ishoma, varwere vanogona kuenderera mberi nekutora zvimisikidzo, asi kana chiropa chikaita zvakanyanya kukanganiswa, imwe med ingangodaro yakatemwa.

4. Kurasika ndangariro nekuvhiringidzika

Harvard Chiremba Chikoro inonongedzera kuongororo ya2015 yakaburitswa muna JAMA Yemukati Mushonga iyo yakaongorora kubatana kunogona kuitika pakati pemafuta-ekuderedza mishonga uye kurasikirwa ndangariro. Mushure mekuongorora zvinyorwa zvekurapa zvevarwere vangangosvika mamirioni gumi nerimwe, vaongorori vakaona kuti vanhu vakuru vakatora masitiniki (pamwe nechero rudzi rwecholesterol zvinodhaka) vaive nekanenge kane mukana wekutaura kukanganisika kwekuziva kana vachienzaniswa neavo vaisatora iyo imwechete kirasi of meds. Nekudaro, Harvard anowedzera kuti kushamwaridzana hakukwanisi kupihwa misiyano yakakosha mukushanda kwemasitadhi uye asiri e statin cholesterol.

Uyezve, mune yegore ra2016 rejenali Chirwere cheshuga , vanyori vekudzidza kubva kuIsrael vakaongorora mhedzisiro kubva kune yakafanana yekucherechedza uye vanotarisirwa ekuedzwa miedzo. Zvavakawana: Zvakataurwa zviitiko zvekurasikirwa nendangariro zvaive zvisingawanzoitika, uye vaferesi vakapedzisa kuti hukama hwehukama hunofanira kusimbiswa.

Mimwe mhedzisiro yakataurwa kubva kumatanho inosanganisira:

• Kutemwa nemusoro
• Kunetseka kurara
• Nausea
• Dzungu
• Bloating
• Manyoka
• Rhabdomyolysis
• Mapundu

Njodzi zvinhu zvekusagadzikana kwesitina, sekureva iyo Mayo Clinic , inosanganisira:

• Ndechikadzi
• Vari pamusoro pemakore makumi masere
• Iva nemuviri mudiki furemu
• Iva neitsvo kutadza kana chirwere chechiropa
• Iva ne hypothyroidism kana neuromuscular disorder
• Tora mimwe mishonga yekurapa cholesterol kana hutachiona
• Shandisa doro rakawandisa
• Shandisa huwandu hwakawanda hwemazambiringa, kusanganisira muto wemazambiringa

Dr. Haythe vanoti mamwe mhedzisiro yematemini anogona kutarisirwa nerubatsiro rwechiremba, uyo anogona kukurudzira kuchinjira kune imwe statin kana kudzikisa muyero wemushonga. Taura nachiremba wako kana uri kusangana nemimwe migumisiro yakaipa.