Zvese zvaunoda kuti uzive nezve biologics ye psoriasis
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Chii chinonzi psoriasis?
Icho chisingaperi autoimmune chirwere cheganda chinomhanyisa kukura kwekutenderera kwemasero eganda, maererano ne Nzvimbo dzeDziviriro Kudzora uye Kudzivirira (CDC) . Psoriasis inokonzeresa, mitsipa, makwapa echitsvuku kana sirivheri paganda jena, nepepuru, grey, kana matete akasviba paganda reruvara. Inowanzo bata magokora, mabvi, ganda romusoro, zasi kumashure, kumeso, zvanza, uye tsoka dzetsoka. Asi, zvakare inogona pamusoro penzara, nzwara, uye muromo.
Fomu yakajairika yechirwere cheganda iri - inobata pakati pe80% ne90% yevanhu vanoonekwa kuti vane psoriasis- plaque psoriasis, iyo inoratidzirwa nemaronda akasimba-akasimudzwa zvigamba (kana mabara) ayo anowanzo tsemuka uye kubuda ropa, maererano American Academy yeDermatology (AAD) .
Psoriasis inofungidzirwa kuti inokonzerwa nehunhu hwakatemerwa uye kusagadzikana kwema immune system kuratidza izvo zvinoita kuti maseru eganda akure nekukurumidza, kuita murwi pamusoro peumwe, uye kutungamira kuchinje cheganda, anodaro Brendan Camp, MD, FAAD , mbiri bhodhi-yakasimbiswa dermatologist uye dermatopathology nyanzvi inoshanda paMedical Dermatology & Cosmetic Surgery muNew York City.
Inoenderana: Rinongova ganda rakaoma here? Kana kuti ingave eczema? Kana psoriasis?
Iyo AAD inoti kunyangwe hosha yeganda isingatapurirane, zvimwe zvinokonzeresa zvinogona kuwedzera zviratidzo uye zvichikonzera kuputika, senge:
- Kushungurudzika
- Kukuvara kweganda (semuenzaniso, kudzika kwakadzika kana kupisa kwezuva)
- Utachiona
- Mimwe mishonga yemishonga (semuenzaniso, lithiamu uye zvideo )
- Mamiriro ekunze (kazhinji kutonhora kutonhora uye yakaoma mamiriro)
- Fodya
- Doro
Psoriasis inogona zvakare kutungamira mukubatana uye musana kurwadziwa, kuomarara, uye kuzvimba, mamiriro anonzi psoriatic arthritis, anodaro Stacy Chimento, MD , bhodhi-rakasimbiswa dermatologist uyo anoshanda kuRwizichase Dermatology muMiami. Nehurombo, psoriasis inogara kwenguva refu, isingagumi isina mushonga unozivikanwa, anotsanangura-asi kune nzira dzekurapa.
Biologics ye psoriasis
Kwemakore gumi apfuura, biologics yakave inovimbisa yekurapa sarudzo yeplata psoriasis. Ivo ndeimwe nzira kune yechinyakare mishonga, senge misoro yemakirimu uye kurapa kwakapfava.
Chii chinonzi biologics?
Biologic zvinodhaka zvinogadzirwa muhupenyu hwehupenyu (senge microorganisms, chirimwa, kana masero emhuka), nepo mishonga yakajairika iri mubatanidzwa wezvakakosha zvemakemikari zvigadzirwa, anotsanangura Dr. Chimento. Kunyanya zvakanyanya, biologics inoshandura immune system nenzira inokanganisa hutachiona hutachiona, kusiyana nemishonga yechinyakare inoshanda pane yako ese immune system.
Biologics inoshandira sei psoriasis?
Kana zvasvika kune iyo kurapwa kwe psoriasis , biologics yakagadzirirwa kuvharira chero chiito cheiyo chaiyo immune cell (inozivikanwa seT-cell) kana mapuroteni mukati memasoja emuviri, akadai bundu necrosis factor-alpha (TNF-alpha), interleukin 17-A, kana interleukins 12 uye 23.
Mu psoriasis, mameseji asina kujairika nemapuroteni madiki anonzi cytokines anomutsa maseru eganda kuti akurumidze kukura, anodaro Dr. Camp. Biologics inovhara iwo mameseji kubva mukugamuchirwa uye kudzima iwo anoenderana zviratidzo nezviratidzo zve psoriasis.
Nei uchishandisa biologics?
Vanopa hutano vanowanzo gadza biologics, rudzi rwemushonga wesystem, kune varwere vane mwero kusvika kune zvakanyanya psoriasis - avo vanoongororwa ne3% kusvika 10% muzana (kana kupfuura) yemuviri uri kubatwa nechirwere ichi, anodaro Dr. Chimento. Kunyangwe psoriasis ichingobata chikamu chidiki chemuviri wako, inogona kutariswa seyakaomarara kana ikabata hupenyu hwako hwezuva nezuva, anoenderera mberi. Chiremba anogona zvakare kuratidza biologics kana mishonga yechinyakare (kusanganisira ma topical makirimu, corticosteroids, cyclosporine, uye retinoids) yakatadza kubata zviratidzo.
Unogara kwenguva yakareba sei pa biologics ye psoriasis?
Biologic kurapwa kunoitwa neiyo intravenous (IV) kumisikidzwa kuhofisi yechiremba kana jekiseni (kungave kuzvidzivirira-kwako kana kupihwa nemupi wako wezvehutano). Sezvo psoriasis iri chirwere chisingaperi, varwere vanogona kugara pane biologic nekusingaperi kuti vazvidzore, anodaro Dr. Camp. Zvakare, kutora biologic uchienderera kunoshanda kupfuura kuimisa uye kuitangisa sezvo izvi zvinogona kukonzera kuti mushonga urasikirwe nehunoshanda. Kana zvikaitika kuti imwe biologic ikatadza kushanda, chiremba angangopa chimwe chiratidzo chakasiyana.
Ndeipi njodzi dzebiologics?
Vese Dr. Camp naDr Chimento vanotaura kuti nekuda kwekuti biologic mishonga inodzvinyirira immune system, varwere vanogona kubatwa nehutachiona hwakakomba. Muzviitiko zvisingawanzoitika, mhedzisiro yacho inogona kutyisidzira hupenyu, kusanganisira hutachiona hwehutachiona senge tibhii, mabayo, kana staph uye hutachiona, anowedzera Dr. Chimento. Muchokwadi, zvakakosha kuti uongororwe tibhii usati watanga biologic, uye varwere vanotora iri boka remishonga havafanirwe kuwana majekiseni mhenyu, Dr. Camp vanodaro.
Yakakurumbira biologic mishonga ye psoriasis
Aya ndiwo mashoma eakakurumbira FDA (Kudya neDrug Administration) inogamuchirwa biologics pamusika nhasi.
| Zita remishonga | Nzira yekutungamira | Standard muyero | Zvakajairika mhedzisiro | Tora coupon |
| Cosentyx(secukinumab) | Jekiseni | 300 mamirigiramu kamwe pavhiki kwemavhiki mana, uye 1 jekiseni mwedzi wega. 150 mamirigiramu anogona kushandira vamwe varwere. | Zviratidzo zvinotonhora, manyoka, uye zvepamusoro zvirwere zvekufema | Tora coupon |
| Skyrizi(risankizumab-rzaa) | Jekiseni | 75 mamirigiramu. Pakutanga 2 doses pamusoro pevhiki ina, ipapo 1 dhizeti vhiki dzese gumi nembiri. | Zvirwere zvepamusoro zvekufema, kutemwa nemusoro, kuneta, jekiseni saiti, uye chirwere chetinea | Tora coupon |
| Ilumya(tildrakizumab-asmn) | Jekiseni | 100 mamirigiramu. Pakutanga 2 doses pamusoro pevhiki ina, ipapo 1 dhizeti vhiki dzese gumi nembiri. | Utachiona hwepamusoro hwekufema, jekiseni saiti, uye manyoka | Dzidza ZVIMWE |
| Orencia(abatacept) | Jekiseni (ese akafarira sirinji uye autoinjector) uye IV | IV Kukanganiswa: Kurema kwakavakirwa dosi yakapihwa yega yega mavhiki maviri e3 doses, uyezve ese masvondo mana mushure maizvozvo (Vakuru vanorema isingasviki 60 kg: 500mg, 60 kg - 100 kg: 750 mg, yakakura kupfuura 100 mg: 1000mg) Subcutaneous: 125 mg vhiki nevhiki, iine kana isina IV kurodha dosi. | Kutemwa nemusoro, hutachiona hwepamusoro hwekufema, huro, uye kusvotwa | Dzidza ZVIMWE |
Inokurumidza sei biologics inoshanda?
Varwere vanogona kutarisira kuona kugadzirisa mukati memasvondo gumi nemaviri nemhedzisiro inogara kwemwedzi yakati wandei, anodaro Dr. Chimento. Kunyangwe ichisiyana kubva pamunhu kuenda kumunhu, mumwe munhu ane hunyoro kesi ye psoriasis anogona kuona zviratidzo zvichideredzwa nekukurumidza sevhiki rimwe chete.
Uye mhedzisiro yenguva refu inonakidza. Kune vazhinji varwere, kutora biologic kwave kuri kuchinja hupenyu nekuti kwakabatsira apo mamwe marudzi ekurapa asina, akadaro Dr. Camp. Mimwe mishonga inogona kupa kuregererwa kubva ku psoriasis, umo ganda rakajeka kana kuti rinenge rakajeka.
RELATED: Izvo zvazviri chaizvo sekugara ne psoriasis
Yakawanda zvakadii biologics ye psoriasis mutengo?
Iyi kirasi yezvinodzvinyirira zvinodhaka ndeimwe yemishonga inodhura. Pasina inishuwarenzi, biologics inogona kudhura chero kupi kubva pamadhora zviuru gumi kusvika pamadhora zviuru makumi matatu pagore, zvinoenderana nemushonga uye muyero, anodaro Dr. Chimento. Kunze kwekunge mamiriro ako akanyanya, inishuwarenzi yako isingavhare biologics kusvika iwe waedza imwe kana yakawanda yekurapa kwehurongwa, se methotrexate kana retinoids.
Kunyangwe iwe uine inishuwarenzi yehutano , Dr. Camp anowedzera kuti makambani mazhinji emishonga anopa rubatsiro rwemari kuburikidza nema-co-kubhadhara rubatsiro zvirongwa. SingleCare inoshanda pamwe neanopfuura makumi matatu nemakumi matatu mafarmasi nyika (kusanganisira CVS, Target, Walgreens neWalmart) uye inopa mahara emamwe coupon ekuwedzera kuchengetedza.
