Nei autoimmune kusagadzikana kuchinyanya kuwanikwa muvakadzi?

Dzidzo yehutano

Pandaive akawanikwa aine rheumatoid arthritis , Ndakabva ndangoda kuziva zvakawanda nezvechirwere ichi uye kuti chingakanganisa sei hupenyu hwangu. Chimwe chinhu chandakatoshamiswa kuona ndechekuti nepo vangangoita 8% yevagari vanobatwa nechirwere che autoimmune, vakadzi vanogadzira padyo ne80% yezviitiko zvese muU.S. . Nei vakadzi vachikanganiswa zvisingaenzaniswi? Kuti uwane mhinduro,Izvo zvakakosha kuti utange unzwisisa izvo zvinoumba autoimmune kusagadzikana.

Ndezvipi autoimmune kusagadzikana?

Chirwere chekuzvimiririra chinoitika kana immune system, iyo inowanzo kurwisa hutachiona, hutachiona, uye hutachiona zvisirizvo zvichirwisa muviri wako. Kune zvinopfuura zana zvirwere zvemuviri. Chirwere chega chega chakasarudzika, asi vazhinji vanogovana zviratidzo izvi:

• Kuneta
• Dzungu
• Zvakaoma kuisa pfungwa
• Low-grade fever
• Unhu uye kurira mumaoko nemakumbo
• Bvudzi kurasikirwa
• Ganda rinoshanduka kana kuputika

Nekuti izvi zvekutanga zviratidzo hazvina kujeka, zvinogona kuve zvakaoma (uye kutora imwe nguva) kuti uwane chaiyo kuongororwa.Zvirwere zve autoimmune zvinowanzo kuongororwa kuburikidza neyakajeka nhoroondo uye kuongorora kwepanyama, kuongororwa kweropa, imaging (X-rays, MRI's, uye ultrasound test), uye kumwe kuongorora.

Ndezvipi zvirwere zvinowanzoitika mumuviri?

Zvimwe zvezvirwere zvakajairika zve autoimmune zvinosanganisira:

• Zvirwere zvehutachiona
• Psoriasis
• Tora 1 chirwere cheshuga
• Chirwere chekuputira ura
• Rheumatoid arthritis
• Lupus
• Multiple sclerosis

Vakadzi vanowanzo kuve nezvirwere zvemuviri mukati memakore avo ekubereka , pakati pemakore gumi nemaviri nemakumi mashanu nemashanu.Zvirwere zvemuviri zvoga senge rheumatoid arthritis, lupus, Hashimoto's disease [low thyroidism], Sjogren's syndrome, Grave's disease [high thyroidism], uye multiple sclerosis inobata vakadzi kupfuura varume, anodaro Magdalena Kadhi, MD , muNew York- based rheumatologist uye shamwari inopinda ku NYU Langone Medical Center.

Sei vakadzi vaine autoimmune hosha kupfuura varume?

Nyanzvi zhinji dzinofunga kuti mubatanidzwa wehomoni (kunyanya estrogen), genetics (iyo X chromosome), uye immune system mhinduro.

Uchapupu hunoratidza kuti estrogen inogona kutora chinzvimbo mukupararira kwezvirwere zvemuviri muvakadzi. Vazhinji vakadzi vanoonekwa kuti vane lupus panguva yekuzvara makore apo estrogen mazinga akwiridzwa, Dr. Cadet anodaro. Estrogen inogona kunyatso kuwedzera kuzvimba (iyo yakaratidzirwa kukonzera uye kufambira mberi vazhinji zvirwere zvakajairika ) apo testosterone yanga ichifungidzirwa kudzikisa mamaki ekuzvimba. Kuzvimba kunoita basa muzvirwere zvakawanda zvisingaperi.

Vakadzi vanogona kuve vanokwanisa kuwana autoimmune chirwere chikamu nekuda kwebasa iro genetics inoenderana ne immune immune kana X chromosome, anotsanangura Dr. Cadet. Zvimwe zvidzidzo zvevanhu uye zvemhuka zvakawana geni pane X chromosome inogona kutsanangura fungidziro yemukadzi kuve nechirwere chemuviri, Asi, zvimwe zvidzidzo zvinofanirwa kuitwa kuongorora iyi fungidziro.

Alexander Shikhman, MD, inobatanidza rheumatologist ine doctorate muhutachiona hwehutachiona uye muvambi we Institute for Yakasarudzika Mishonga muSan Diego inosimbisa iro basa remajini uye immune immune sezvinhu zvinobatsira mukukudziridzwa kwezvirwere zvemuviri.Zvinonyatso kuzivikanwa kuti kutaura kweyekudzivirira immune mumadzimai kwakanyanya kuita kuti vakadzi vawedzere kuzvirwere zvemuviri, anotsanangura Dr. Shikhman. Toll-like receptors, antigen anouya maseru, dendritic maseru, B maseru akanyanya kukwirira muvakadzi. Zvichitaurwa zviri nyore, vakadzi vane yakawedzera immune reactivity (zvichienzaniswa nevarume) -izvo zvinoita kuti vasanyanya kubatwa nehutachiona hutachiona, asiwo inofanotungamira ivo kuzvimirira nekuda kweye hyper-immune mhinduro.

Chii chinokonzera autoimmune chirwere mumadzimai?

Pane dzidziso dzinoverengeka dzekuti chii chinokonzeresa auto-immune chirwere mumadzimai kusanganisira hutachiona, hwakanyanya simba immune mhinduro, kushushikana, genetics, uye chikafu.

Zvidzidzo zvakaratidza kuti hutachiona hunogona kushanda sekukonzeresa kwenzvimbo yekuzvimiririra (iyo yakasarudzika mhinduro yekudzivirira inoita kuti muviri urwise pachako). Mukuita kwedu, isu tinogara tichiongorora hutachiona husingaperi hunotungamira chirwere chemuviri, Dr. Shikhman anotsanangura. Mune ruzivo rwedu, kusangana nezvirwere zvinotapukira kunoguma nenjodzi huru yekuzvimiririra muvakadzi kupfuura varume sezvo isu tichiwanzo kuona kuratidzwa kwekiriniki yezvirwere zvisingaperi zvakanyanya kunetsa mumadzimai. Zvinoreva, vakadzi vanowanzo kuve ne autoimmune reaction mushure mehutachiona kupfuura varume.

Sekureva kwa Dr. Cadet,Vakadzi zvakare vanogona kuve vanokwanisa kuburitsa akawanda maantibhakitiriya mune yavo immune mhinduro pavanotarisana nehutachiona, kushungurudzika, kana kubaiwa. Anoti zvirwere zvakawanda zvemuviri zvinopindirana nema auto-antibodies senge muRA, Sjogren's syndrome, uye lupus. Ma autoimmune antibodies mapoka emaprotein ekudzivirira anogona kukuvadza muviri. Izvi zvinoitika kana immune system yavhiringika uye isingakwanise kutaura mutsauko pakati peako neasingaite mapuroteni. Auto-antibodies inogona kukonzera kuzvimba uye kukuvadza hutano hwakanaka uye nhengo, zvichitungamira kuchirwere chemuviri.

Zvimwe zvinokonzeresa zvezvirwere zvemuviri zvinogona kusanganisira genetics, kana a Kudya kwekumadokero , iyo inosanganisira mafuta ane mafuta akawanda uye cholesterol, mapuroteni mazhinji, shuga yakawanda, uye munyu wakawandisa uye chikafu chinogadzirwa.

Vanogona vakadzi kukudziridza akawanda autoimmune hosha?

About 25% yevarwere vane autoimmune hosha vane tsika yekukudziridza zvimwe autoimmune hosha. Mune mamwe mazwi,autoimmune hosha dzinogona kuitika mumasumbu.

Pane chiitiko chinonyatso kuzivikanwa mune immunology chinonzi 'autoimmune epitope inopararira,' Dr. Shikhman anotsanangura. Iyo inotsanangura kusimudzira kweakasiyana maitiro autoimmune mumunhu akapihwa. Mukupindura kune antigen, B maseru anogadzira antibodies; antibody 'akanakisa' anokunda uye anogadzira kurwisa. Nekufamba kwenguva antibody yekutanga inokunda inotanga kutora mamwe maB masero anogadzira masoja ekudzivirira anowedzera kurwisa kwemamwe matishu.

Tsvagiridzo yakaitwa pa Boston Children's Hospital uye Harvard Medical chikoro inotsanangura maitiro aya sekutiza kwechitima chiitiko che autoimmune chirwere. Kamwe iyo autoimmune mhinduro ikakonzerwa, pane iko kukanzura mhedzisiro ye autoimmune mhinduro, izvo zvinogona kutungamira mukuvandudzwa kwevamwe autoimmune kusagadzikana.

Kurapa kwezvirwere zvemuviri

Kunyange pasina mushonga we autoimmune hosha, kufambira mberi mumishonga kuri kupa kwakajeka kufungidzira uye kushanda kwevarwere. Lifestyle moditions inogona kubatsira zvakanyanya mukuderedza kana kudzikamisa auto-immune flare kumusoro. Zvinosanganisira:

• Kushushikana mupfungwa
• Kudya zvine hutano
• Rovedza muviri
• Biofeedback
• Kuderedza doro, fodya, kana zvimwe zvinoshandiswa
• Maitiro akanaka ekurara
• Hukama hwakanaka
• Kurapa kwepanyama

Sarudzo dzekurapwa dzinosiyana nezvezvimwe zvirwere, asi zvinogona kusanganisira:

• Nonsteroidal anti-anogumbura zvinodhaka ( ibuprofen , naproxen ): Iyo inozivikanwawo seNSAIDs, iyi mishonga inorapa kurwadziwa uye inoderedza kuzvimba.
• Corticosteroids ( zvideo , cortisone Iyi mitsara inorwisa kuzvimba uye inoderedza immune system chiitiko.
• Hormone kutsiva ( jekiseni , levyothyroxine Mamiriro ekuzvidzivirira akadai seType 1 chirwere cheshuga, uye hypothyroidism inoda kuenderera ichitsiva imwe mahormone.
• Immunosuppressants ( cyclosporine , methotrexate ): Iyi mishonga inodzvinyirira immune immune uye inogona kushandiswa kurapa lupus, rheumatoid arthritis, uye psoriasis.
• Intravenous immunoglobulin : Iyi kurapa inoshandisa musanganiswa wemasoja ekudzivirira kurapa akati wandei mamiriro ehutano.
• Biologics ( Humira , Enbrel , Remicade , Cosentyx , Ocrevus ): Iyi mishonga inouya kubva kune zvipenyu uye inovharira immune nzira munzira mumasero.

Chakavanzika chekuti nei autoimmune hosha dzinokanganisa vakadzi zvakanyanya kupfuura varume chakasiyana-siyana, asi sainzi painofambira mberi, ndozvinoitawo mukana wekufambira mberi mune zvekurapa uye kuti varwere vave nehupenyu hwakanaka. Vakadzi vanoona autoimmune kusagadzikana vanogona kuwana hwakakwirira hunhu hwehupenyu nekwakasiyana-siyana kurapwa timu uye nemuviri wese nzira kune hutano.