Glipizide vs. metformin: Misiyano, kufanana, uye izvo zviri nani kwauri
Zvinodhaka Vs. ShamwariKuongorora kwemishonga & misiyano mikuru | Conditions kurapwa | Kubudirira | Inishuwarenzi kufukidza uye mutengo kuenzanisa | Zvimwe zvinokanganisa | Kubatana kwezvinodhaka | Yambiro | MIBVUNZO
Glipizide uye metformin mishonga miviri inoshandiswa kurapa Type 2 chirwere cheshuga mellitus. Vanhu vane Type 2 chirwere cheshuga vane dambudziko nehomoni insulin, inova inokonzeresa kufambisa shuga yeropa (glucose) mumasero emuviri kwesimba. Kana insulin isingashande zvakare, insulin kudzvinyirira kunogona kukura uye kunotungamira kuwanda kweglucose mazinga, ayo anogona kuzotungamira kune mamwe matambudziko ehutano. Glipizide uye metformin inogona kubatsira kudzora huwandu hweglucose kudzikisa njodzi yezvinetso kubva kuchirwere cheshuga.
Inofananidzwa nevamiririri vatsva, glipizide uye metformin mishonga isingadhuri yemishonga inorwisa chirwere cheshuga. Ivo ese ari maviri anoshandiswa kwenguva refu-manejimendi eType 2 chirwere cheshuga. Kunyangwe paine zvakafanana muhuwandu hwezvinhu, glipizide uye metformin zvine misiyano yakati wandei, kunyanya mashandiro ainoita, mhedzisiro mhedzisiro, uye kudyidzana kwezvinodhaka.
Ndeupi mutsauko mukuru pakati pe glipizide uye metformin?
Glipizide
Glipizide izita rakajairika reGlucotrol. Icho chikamu chekirasi yemishonga inonzi sulfonylureas, uye inoshanda na kukurudzira kuchengetedzwa kwe insulin kubva mupancreas. Iko kuwedzera kwe insulini kunobatsira kudzikisa huwandu hweropa glucose mumuviri.
Glipizide inowanikwa se5 mg kana 10 mg piritsi remuromo. Generic glipizide inouyawo mumapiritsi akawedzerwa-akasimba musimba re2,5 mg, 5 mg, uye 10 mg. Glipizide inowanzo kutorwa kamwe zuva nezuva usati wadya.
Metformin
Metformin izita rakajairika reGlucophage kana Riomet, uye ndeyekirasi yemishonga inonzi biguanides. Metformin inoshanda kurapa Type 2 chirwere cheshuga ne kudzikira kugadzirwa kweglucose muchiropa uye kuderera kwekutorwa kweshuga mumatumbu. Izvo zvinoshandawo nekuwedzera insulin senzwi uye kuwedzera kutora kweglucose mumatumbu emuviri.
Metformin inowanikwa sehwendefa remuromo musimba re500 mg, 850 mg, uye 1000 mg. Yakawedzerwa-kuburitsa metformin mapiritsi inowanikwa uye yakagadzirirwa kutorwa kamwe chete zuva nezuva. Pakarepo-kuburitswa metformin inowanzo gadzirirwa kutorwa kaviri zuva nezuva.
| Misiyano mikuru pakati pe glipizide uye metformin | ||
|---|---|---|
| Glipizide | Metformin | |
| Kirasi yemishonga | Sulfonylurea | Biguanide |
| Brand / generic chinzvimbo | Brand uye generic vhezheni iripo | Brand uye generic vhezheni iripo |
| Chii chinonzi zita rechiratidzo? | Glucotrol | Glucophage Riomet |
| Ndeapi mafomu (s) ayo mushonga unouya? | Hwendefa remuromo | Hwendefa remuromo |
| Ndeipi muyero wakajairwa? | 5 mg kamwe zuva nezuva usati wadya. Chipimo chemushonga chinogona kuchinjika zvinoenderana nemhinduro uye nemamiriro ekurapa. Kunonyanyisa dose 40 MG pazuva. | 500 mg kaviri pazuva kana 850 mg kamwe zuva nezuva nekudya. Chipimo chemushonga chinogona kuchinjika zvinoenderana nemhinduro uye nemamiriro ekurapa. Yakawanda mwero we2,550 mg pazuva. |
| Yakareba sei iyo yekurapa? | Yenguva refu yeshuga manejimendi manejimendi | Yenguva refu yeshuga manejimendi manejimendi |
| Ndiani anowanzoshandisa mushonga? | Vakuru vane makore gumi nemasere zvichikwira | Vakuru nevana vane makore gumi zvichikwira |
Mamiriro ezvinhu anorapwa ne glipizide uye metformin
Glipizide uye metformin ese ari maviri FDA-anotenderwa kurapa Type 2 chirwere cheshuga mellitus. Kudzora huwandu hweshuga yeropa kunogona kubatsira kudzikisa njodzi yezvinetso kubva kuchirwere cheshuga. Aya matambudziko anogona kusanganisira chirwere chemoyo, chirwere cheitsvo, chirwere chechiropa, kukuvara kwemaziso, uye hutachiona hwetsoka.
Metformin dzimwe nguva inoshandiswa isiri-yekuraira kurapa mamwe mamiriro, senge gestational chirwere cheshuga, kana chirwere cheshuga panguva yekuzvitakura, uye polycystic ovary syndrome (PCOS) . Metformin inoshandiswa zvakare kure-kutapira kurapa kurema kunokonzerwa senge divi mhedzisiro yemimwe mishonga yekurapa.
Hapana ongororo yakakosha yakaitwa pane isiri-chitaridzi mashandisiro e glipizide.
| Mamiriro | Glipizide | Metformin |
| Nyora 2 chirwere cheshuga mellitus | Ehe | Ehe |
| Gestational chirwere cheshuga | Kwete | Kunze-chitaridzi |
| Polycystic ovary chirwere | Kwete | Kunze-chitaridzi |
| Kurera huremu nekuda kweantipsychotic kurapa | Kwete | Kunze-chitaridzi |
Glipizide kana metformin inoshanda here?
Glipizide uye metformin ese ari maviri anoshanda eshuga mishonga yekuvandudza glycemic kutonga mune vanhu vane Type 2 chirwere cheshuga. Inogona kushandiswa semonotherapy kana semubatanidzwa piritsi inonzi Metaglip. Glipizide uye metformin inoshanda zvakanyanya kana ikashandiswa nechikafu chakakodzera uye regimen yekurovedza muviri.
Metformin inoramba iri yekutanga-tambo yekurapa yeType 2 chirwere cheshuga, zvinoenderana nemazano kubva ku American Chirwere cheshuga Association (ADA) . Kana ichienzaniswa nekubudirira kune avo vane Type 2 chirwere cheshuga uye coronary artery chirwere, metformin inoderedza njodzi yekurwadziwa kwemoyo uye kurohwa kupfuura glipizide. Zvinoenderana nekaviri-bofu, kliniki kuyedzwa, metformin yakaratidza yakakura cardioprotective maitiro kupfuura glipizide mushure memakore mashanu emakore.
Imwe kuenzanisa kuyedzwa vakawana kuti metformin yakapa nani kudzora shuga muropa kupfuura glipizide. Avo vanotora metformin muchidzidzo vaive nekutsanya kuri nani mwero weplasma glucose pane glipizide mushure memasvondo makumi maviri nemana, makumi matatu nemasere, nemakumi mashanu nemashanu. Ivo vanotora metformin vaivewo neyezasi HbA1c chikamu pane avo vanotora glipizide mushure memasvondo makumi mashanu nemaviri. Metformin yakakonzera kuonda uye glipizide yakakonzera huremu mune vanorapwa vatori vechikamu.
Bvunza mupi wezvehutano nezvehutano hwakanakisisa iwe kana uine Type 2 chirwere cheshuga. Zvichienderana nehutano hwako hwese, shuga zveropa , uye mimwe mishonga yaungave uri kutora, mumwe mushonga unogona kusarudzwa pane mumwe.
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Kuvhavha uye mutengo kuenzanisa kwe glipizide vs. metformin
Glipizide ndeye generic antidiabetic mishonga iyo inowanzo kuvharwa neMedare uye zvirongwa zveinishuwarenzi. Kune yakajairwa kupihwa kwe glipizide, iyo copay inogona kutangira pamadhora 0 kusvika $ 9. Wepakati mutengo wekutengesa we glipizide unogona kutenderedza madhora makumi matatu. YegaCare glipizide coupon inogona kubatsira kudzikisa mutengo kusvika kumadhora mana kumafarmacy anotora chikamu.
Metformin inowanzo gadzirirwa antidiabetic mishonga iyo inovharwa neakawanda maMedare uye zvirongwa zveinishuwarenzi Iyo yakajairwa Medicare copay inogona kutangira pamadhora 0 kusvika $ 8, uye mutengo wekutengesa unogona kutenderedza madhora makumi maviri nemashanu zvichienderana nekhemisi yaunoenda. Metformin coupon kubva kuSingleCare inogona kudzora mutengo kusvika kudzika semadhora mana.
| Glipizide | Metformin | |
| Kazhinji yakafukidzwa neinishuwarenzi? | Ehe | Ehe |
| Inowanzo kufukidzwa neMedare Chikamu D? | Ehe | Ehe |
| Standard muyero | 5 mg kamwe pazuva (huwandu hwemapiritsi makumi matanhatu) | 500 mg kaviri pazuva (huwandu hwemapiritsi makumi matanhatu) |
| Chaizvoizvo Medicare copay | $ 0– $ 9 | $ 0– $ 8 |
| SingleCare mutengo | $ 4 + | $ 4 + |
Zvakajairika mhedzisiro mhedzisiro ye glipizide vs. metformin
Mhedzisiro inowanzoitika paglipizide inosanganisira shuga shoma yeropa ( hypoglycemia ), kupatira, manyoka, kuda kurutsa, uye dzungu.
Mhedzisiro inowanzoitika yemetformin inosanganisira manyoka, kuda kurutsa, kushaya simba (asthenia), hypoglycemia, uye musoro.
Yakakomba mhedzisiro mhedzisiro ye glipizide inosanganisira yakaoma hypoglycemia uye hemolytic anemia. Yakakomba mhedzisiro mhedzisiro ye metformin inosanganisira lactic acidosis uye kushayikwa kwevhitamini B12. Bvunza mupi wezvehutano nezve zvimwe zvingave zvinokanganisa glipizide kana metformin.
| Glipizide | Metformin | |||
| Side maitiro | Zvinoshanda? | Kakawanda | Zvinoshanda? | Kakawanda |
| Hypoglycemia | Ehe | * | Ehe | 1% -5% |
| Kuzvimbirwa | Ehe | * | Kwete | - |
| Manyoka | Ehe | * | Ehe | 53% |
| Nausea | Ehe | * | Ehe | 26% |
| Dzungu | Ehe | * | Kwete | - |
| Kushaya simba | Kwete | - | Ehe | 9% |
| Kutemwa nemusoro | Ehe | * | Ehe | 6% |
* haina kutaurwa
Kakawanda hakubvi pane data kubva kumusoro-kuenda-kumusoro kutongwa. Izvi zvinogona kunge zvisiri runyorwa ruzere rwemhedzisiro mhedzisiro inogona kuitika. Ndokumbira utarise kuna chiremba wako kana mupi wezvehutano kuti udzidze zvimwe.
Kwayaka: DailyMed ( Glipizide ), Zuva Nezuva ( Metformin )
Kubatana kwezvinodhaka kwe glipizide vs. metformin
Glipizide uye metformin inogona kudyidzana nemishonga yakafanana. Mimwe mishonga inogona kuwedzera shuga yeropa kudzikisa mhedzisiro ye glipizide uye metformin, iyo inogona kuwedzera njodzi ye hypoglycemia. Iyi mishonga inosanganisira mamwe antidiabetic madhiragi uye mamwe anodzvinyirira eropa kudzikamisa vamiririri vakaita seACE inhibitors uye angiotensin mhando II receptor blockers.
Mimwe mishonga inogona kudzikisira mashandiro anoita glipizide uye metformin, izvo zvinogona kudzikisira shuga yavo muropa. Iyi mishonga inogona kusanganisira calcium chiteshi blockers, diuretics, corticosteroids, beta blockers, uye nemuromo zvekudzivirira. Zviratidzo zve hypoglycemia zvinogona kuvharwa paunenge uchitora beta blockers, saka vanofanirwa kuongororwa kune vanhu vanotora mishonga iyi.
Metformin inogona zvakare kudyidzana neacabhoni anhydrase inhibitors, senge topiramate uye zonisamide, iyo inogona kuwedzera njodzi yeactic acidosis. Mimwe mishonga yakadai sa ranolazine uye vandetanib inogona kusangana ne metformin uye inopindira nekubviswa kwayo kubva kuitsvo. Iyi mishonga inogona kuwedzera mazinga e metformin muropa uye inowedzera njodzi ye lactic acidosis.
| Zvinodhaka | Kirasi yemishonga | Glipizide | Metformin |
| Topiramate Zonisamide Acetazolamide Dichlorphenamide | Carbonic anhydrase inhibitors | Kwete | Ehe |
| Ranolazine | Antianginals | Kwete | Ehe |
| Vandetanib | Tyrosine kinase inhibitors | Kwete | Ehe |
| Insulin Sitagliptin Dulaglutide Dapagliflozin Miglitol | Antidiabetic vamiririri | Ehe | Ehe |
| Lisinopril Enalapril Captopril | ACE inhibitors | Ehe | Ehe |
| Candesartan Irbesartan Losartan | Angiotensin II receptor inodzivirira vamiririri | Ehe | Ehe |
| Amlodipine Nicardipine Verapamil | Calcium chiteshi blockers | Ehe | Ehe |
| Hydrocortisone Prednisone Methylprednisolone | Corticosteroids | Ehe | Ehe |
| Hydrochlorothiazide Chlorthalidone Indapamide Furosemide Bumetanide | Diuretics | Ehe | Ehe |
| Atenolol Bisoprolol Metoprolol | Beta anovharira | Ehe | Ehe |
| Yakagadziriswa estrogens Ethinyl estradiol Levonorgestrel Norethindrone | Estrogens uye zvekudzivirira pamuromo | Ehe | Ehe |
Bvunza nyanzvi yezvehutano kune kumwe kudyidzana kwezvinodhaka
Yambiro dze glipizide uye metformin
Nekuda kwemabatiro avo eglucose-ekudzikisa, glipizide uye metformin inotakura njodzi ye hypoglycemia, kana yakaderera shuga yeropa. Ngozi ye hypoglycemia inowedzerwa apo glipizide kana metformin inotorwa nemamwe antidiabetic agents. Kugara uchirovedza muviri uye kunwa doro zvinogona zvakare kuwedzera njodzi iyi. Zviratidzo zve hypoglycemia zvinosanganisira kutya, kudikitira, kurova kwemoyo nekukurumidza, uye kuvhiringidzika.
Vamwe vanhu vane glucose 6-phosphate dehydrogenase (G6PD) kushomeka vari panjodzi yekuvandudza hemolytic anemia vachitora glipizide. Nekudaro, vamwe vanhu vasina GP6D kushomeka vanogona zvakare kukura hemolytic anemia.
Iko kushandiswa kwe metformin kunogona kutungamira kune metformin-inosanganisirwa lactic acidosis. Rudzi urwu rwe lactic acidosis inowanzo kuve yakabatana nekuwedzeredza kwemetformin. Zvisinei, kunewo njodzi ye lactic acidosis muvanhu vane yakaderera chiropa kana itsvo mabasa. Zviratidzo nezviratidzo zveactic acidosis zvinosanganisira kusvotwa, kuderera kweropa, uye kurwadziwa mudumbu.
Bvunza mupi wezvehutano nezve zvimwe zvinogona kunyeverwa uye zvidziviriro zvine chekuita ne glipizide kana metformin.
Inowanzo bvunzwa mibvunzo nezve glipizide vs. metformin
Chii chinonzi glipizide?
Glipizide imishonga inowanzoitwa yekirasi yemishonga inonzi sulfonylureas. Zita rezita re glipizide ndiGlucotrol. Glipizide inoshanda nekuwedzera kuburitswa kwe insulini kubva mupancreas kudzikisa shuga zveropa. Iyo inowanikwa sekukurumidza-kuburitsa uye kuwedzeredzwa-kuburitsa piritsi yemuromo.
Chii chinonzi metformin?
Metformin inozivikanwa zvakare nemazita anozivikanwa ezita saRiomet neGlucophage. Icho chiri chekirasi yemishonga inorwisa chirwere cheshuga inonzi biguanides. Metformin inoshanda nekuwedzera insulin kushushikana, kudzikisa kugadzirwa kweglucose muchiropa, uye kudzikira kwekutapukira kwemukati kweglucose. Metformin inowanikwa seinoburitsa-nekuburitsa-kuburitsa piritsi yemuromo.
Glipizide uye metformin zvakafanana here?
Glipizide uye metformin hazvina kufanana. Glipizide is sulfonylurea inobata Type 2 chirwere cheshuga muvakuru uye metformin iguinea inobata Type 2 chirwere cheshuga muvakuru uye vana vane makore gumi nekure. Glipizide uye metformin inoshanda nenzira dzakasiyana uye ine madosi akasiyana.
Glipizide kana metformin iri nani here?
Glipizide uye metformin zvese zvinoshanda kudzikisa huwandu hweropa muropa kune avo vane Type 2 chirwere cheshuga. Sekureva kweAmerican Diabetes Foundation mirayiridzo , metformin ndiyo yekutanga-tambo yekurapa yeType 2 chirwere cheshuga. Glipizide uye metformin dzimwe nguva inogona kutorwa pamwe chete mune zvimwe zviitiko panodiwa kudzikira kweglucose. Pakazara, iyo yakanakisa chirwere cheshuga mishonga inoenderana neyakajairika mamiriro ekurapa uye mhinduro kumushonga.
Ndinogona here kushandisa glipizide kana metformin ndichiri nepamuviri?
Inofananidzwa ne metformin, glipizide inogona kunge iine mukana wepamusoro wekukonzera fetal chepfu. Zvinoenderana nezvidzidzo zvemhuka, metformin inogona kuve yakachengeteka kuti ishandiswe panguva yekuzvitakura; asi hapana ongororo dzakajeka muvanhu dzakaitwa. Bvunza mupi wezvehutano kuti uone yakanakisa yekurapa sarudzo iwe paunenge uine pamuviri.
Ndinogona here kushandisa glipizide kana metformin nedoro?
Hazvikurudzirwi kunwa zvakawandisa doro paunenge uchitora glipizide kana metformin . Kunwa doro kunogona kukonzera mazinga eshuga yeropa asingafungidzike uye kuwedzera njodzi ye hypoglycemia kana hyperglycemia. Doro rinogona zvakare kuwedzera njodzi ye lactic acidosis apo uri pa metformin.
Ndeipi nguva yakanakisa yezuva yekutora glipizide?
Iyo yakanakisa nguva yekutora glipizide iri pamberi pekudya kuitira kuti kuderedze njodzi ye hypoglycemia. Kana iri kutorwa kamwe pazuva, glipizide inokurudzirwa kutorwa usati wadya wekutanga wezuva.
Glipizide yakaipa kune itsvo here?
Kusadzora Type 2 chirwere cheshuga kunogona kutungamira kumatambudziko sekukuvara kweitsvo. Zvisinei, glipizide haizivikanwe kuti inokanganisa itsvo. Kubviswa kwe glipizide kunogona kuderedzwa muvanhu vane kukuvara kweitsvo. Kuunganidzwa kwe glipizide kunogona kubva kwatungamira kune yakanyanya njodzi yehuga hweshuga yeropa.
Ndeupi mushonga wakachengeteka pane Rudzi rwechipiri chirwere cheshuga?
Metformin inowanzo gadzwa seyekutanga-tambo yekurapa yeType 2 chirwere cheshuga muvanhu vazhinji. Imhaka yekuti metformin haina mutengo, yakachengeteka, uye inoshanda. Kuenzaniswa nemamwe antidiabetic vamiririri, metformin yakabatana ne yakaderera kana yakafanana HbA1c mazinga . Iko kushandiswa kwemetformin inosanganisirwa neakaderera zviitiko zve hypoglycemia kupfuura mimwe mishonga yakaita sulfonylureas.
