Metformin vs. metformin ER: Misiyano, kufanana, uye izvo zviri nani kwauri
Dzidzo yehutanoKuongorora kwemishonga & misiyano mikuru | Conditions kurapwa | Kubudirira | Inishuwarenzi kufukidza uye mutengo kuenzanisa | Zvimwe zvinokanganisa | Kubatana kwezvinodhaka | Yambiro | MIBVUNZO
Metformin mishonga inowanzo gadzirirwa inoshandiswa kurapa rudzi rwechipiri chirwere cheshuga mellitus. Iyo antidiabetic mumiririri iyo ndeye yekirasi yemishonga inozivikanwa se biguanides. Inoshanda nekudzora iyo glucose (shuga yeropa) kugadzirwa muchiropa, kudzikisira kuwedzerwa kweglucose mumatumbo, uye kuwedzera insulin senzwi. Metformin inovandudza insulin senzwi nekuwedzera kuwedzerwa kweglucose mumatumbu emuviri.
Rudzi rwechipiri chirwere cheshuga mellitus chinoonekwa kana muviri ukava unopesana nemhedzisiro ye insulin. Insulin ihormone yakakosha inogadzirwa nerwatata uye inoshandiswa kutakura glucose mumasero emuviri kwesimba. Kana muviri usingakwanise kushandisa insulini nemazvo, huwandu hweshuga yeropa hunokwira izvo zvinogona kukonzera kukuvadzwa kweropa netsinga. Pasina kurapwa kwakakodzera, chirwere cheshuga chinogona kutungamira kune matambudziko uye kukuvara kwenhengo dzakadai semwoyo neitsvo.
Metformin inowanikwa mune yekukurumidza-kuburitsa (IR) uye yakawedzera-kuburitsa (ER) fomu. Kunyange mafomu ese e metformin aine chinhu chimwe chete, anotorwa nenzira dzakasiyana. Ivo zvakare vane misiyano mumhedzisiro.
Ndeupi mutsauko mukuru pakati metformin uye metformin ER?
Metformin kana metformin hydrochloride izita rakajairika reGlucophage. Pakarepo-kuburitswa metformin inowanzo dosed se500 mg piritsi inotorwa kaviri zuva nezuva nechikafu. Iko kune zvakare 850 mg piritsi iyo inogona kutorwa kamwe zuva nezuva. Iyo yakanyanya dhosi yemetformin ndeye 2550 mg pazuva pazuva muzvikamu zvakapatsanurwa. Metformin inogona kubata rudzi rwechipiri chirwere cheshuga muvanhu vakuru nevana.
Metformin ER inozivikanwawo nezita rekuti Glucophage XR. Iyo yakawedzeredzwa-kuburitswa vhezheni yemetformin uye inongoda kutorwa kamwe chete zuva nezuva nechikafu. Iyo yakanyanya huwandu hwezuva nezuva dhizaini yemetformin ER ndeye 2000 mg. Kusiyana nekukurumidza-kusunungurwa metformin, metformin ER inongoratidzwa chete kune vanhu vakuru vane mhando 2 chirwere cheshuga. Iyo zvakare ine mashoma emhedzisiro uye inogara kwenguva yakareba kupfuura yakajairwa metformin.
RELATED: Metformin ruzivo | Metformin ER ruzivo
| Misiyano mikuru pakati pemetformin uye metformin ER | ||
|---|---|---|
| Metformin | Metformin ER | |
| Kirasi yemishonga | Biguanide | Biguanide |
| Brand / generic chinzvimbo | Shanduro yeGeneric inowanikwa | Shanduro yeGeneric inowanikwa |
| Chii chinonzi zita rechiratidzo? | Glucophage | Glucophage XR, Fortamet, Glumetza |
| Ndeapi mafomu (s) ayo mushonga unouya? | Hwendefa remuromo | Oral piritsi, yakawedzerwa-kusunungurwa |
| Ndeipi muyero wakajairwa? | 500 mg kaviri pazuva kana 850 mg kamwe zuva nezuva nekudya | 500 mg kamwe kamwe pazuva nekudya kwemanheru |
| Yakareba sei iyo yekurapa? | Nguva yakareba yekutarisira chirwere cheshuga | Nguva yakareba yekutarisira chirwere cheshuga |
| Ndiani anowanzoshandisa mushonga? | Vakuru nevana vane makore gumi zvichikwira | Vakuru |
Mamiriro ezvinhu anobatwa ne metformin uye metformin ER
Ose metformin uye metformin ER ari FDA-anotenderwa kubata mhando 2 chirwere cheshuga mellitus. Zvinoenderana ne American Chirwere cheshuga Association (ADA) , metformin ndiyo yekutanga-kurapa kurapwa kworudzi rwechipiri chirwere cheshuga. Mune varwere vane A1c isingasviki 9% panguva yekuongororwa, metformin inofanira kutanga se monotherapy pane iyo Maitiro Ekurapwa mune Chirwere cheshuga . Metformin inogona kubatsira kugadzirisa glycemic kutonga uye pakupedzisira kudzivirira matambudziko anogona kubuda kubva kuchirwere cheshuga.
Kwete chete kuti metformin inogona kushandiswa kurapa rudzi rwechipiri chirwere cheshuga, asi inogona zvakare kushandiswa kune zvisiri-label zvinangwa. Avo vane prediabetes uye yakanyanya kutsanya plasma glucose (FPG) inogona kukurudzirwa metformin kudzivirira kutanga kwechirwere cheshuga. Metformin inokurudzirwa kana huwandu hweshuga yeropa husingakwaniswe nekudya uye kurovedza muviri chete.
Metformin inogona zvakare kushandiswa senge isiri--label sarudzo yekurapa gestational chirwere cheshuga mellitus. Rudzi urwu rwechirwere cheshuga runowanikwa mumadzimai akazvitakura akasarudzika kuve neshuga. Zvisinei, insulin inowanzoedzwa kutanga.
Metformin zvakare yave iri akadzidza kurapa polycystic ovary syndrome (POCS). Iyi syndrome inoratidzirwa nekusaenzana kwehomoni yebonde iyo inogona kukonzeresa maovarian cysts, yekuenda kumwedzi shanduko, nyaya dzepamuviri, acne, uye insulin kuramba. Metformin inogona kupihwa kubatsira kubatsira kudzikisira insulin kushora, kudzikisa testosterone mazinga, uye kugadzirisa kumwedzi kuenda pamwe nekubereka.
Iko kushandiswa kweantipsychotic mishonga, senge olanzapine, risperidone, uye clozapine, zvinogona kutungamira mukurema. Zvinoenderana nezvimwe ongororo, Metformin yakaratidzirwa kuve inoshanda pakurapa antipsychotic-inosimudzira kuwedzera huremu. Imwe ongororo yakawana kuti metformin yakabatsira kuderedza body mass index (BMI), huremu hwemuviri, uye insulin kudzvinyirira zvichienzaniswa ne placebo kune avo vane antipsychotic-inosimudzira uremu.
| Mamiriro | Metformin | Metformin ER |
| Nyora 2 chirwere cheshuga mellitus manejimendi | Ehe | Ehe |
| Nyora 2 chirwere cheshuga mellitus kudzivirira | Kunze-chitaridzi | Kunze-chitaridzi |
| Gestational chirwere cheshuga mellitus | Kunze-chitaridzi | Kunze-chitaridzi |
| Polycystic ovary chirwere | Kunze-chitaridzi | Kunze-chitaridzi |
| Kurera huremu nekuda kweantipsychotic kurapa | Kunze-chitaridzi | Kunze-chitaridzi |
Iko metformin kana metformin ER inoshanda zvakanyanya?
Kubva pane zvidzidzo zvekuenzanisa metformin uye metformin ER yerudzi rwechipiri chirwere cheshuga mellitus, metformin ER yakawanikwa ichifananidzwa ne metformin mukubudirira. Muchokwadi, metformin ER inogona kunge iri yepamusoro pane yenguva dzose metformin zvichibva pane yayo yepazasi-mhedzisiro mhedzisiro uye nyore kushandisa. Avo vane rudzi rwechipiri chirwere cheshuga mellitus vanogona kunge vachida kutora kamwe-zuva nezuva metformin piritsi panzvimbo yepiri-zuva nezuva piritsi.
Mune imwe yakasarudzika, kliniki yekudzidza , metformin ER yakawanikwa ichishanda kupfuura metformin IR pakurapa varwere vane chirwere cheshuga chechipiri. Avo vanotora metformin ER vakasangana zvirinani glycemic control uye lipid metabolism zvichienzaniswa ne metformin IR.
Imwe yakasarudzika, kaviri-bofu kuyedzwa vakawana kuti kamwe-zuva nezuva metformin ER yaive neyakafanana kushanda uye chengetedzo kune yakajairwa metformin. Uyezve, chidzidzo chakacherekedza mukana weimwe-yezuva nezuva dosing ine metformin ER. Ose metformin uye metformin ER yakavandudza huwandu hweHbA1c pamusoro pemasvondo makumi maviri nemana muzvidzidzo izvo zvisina kumboedza chero imwe nzira yekurapa chirwere cheshuga.
Yakawedzerwa-kuburitsa metformin inogona kusarudzwa pane yekukurumidza-kuburitsa metformin. Izvo zvakaratidzirwa kuve nekutsungirira kuri nani kunyangwe zvingave zvichidhura kupfuura mapiritsi ekuburitsa nekukasira. Izvo zvakakosha kuti ubvunze zano rezvechiremba kubva kune wehutano wezvehutano kana uchisarudza nzira yekurapa yerudzi rwechipiri chirwere cheshuga mellitus.
Kuvhavha uye mutengo kuenzanisa kwemetformin vs. metformin ER
Metformin ndiyo generic vhezheni yeGlucophage. Generic metformin yakafukidzwa neMedare chikamu D uye mazhinji zvirongwa zveinishuwarenzi. Brand-zita Glucophage inogona kudhura uye inodhura avhareji mutengo wekutengesa uri pamusoro pe $ 150. Mari iyi inogona kudzikiswa nekuunza iyo SingleCare kadhi rekudzora kufamasi. Iyo metformin ImweCare kadhi inogona kuunza mutengo kudzikira kumadhora mana kune makumi matatu-mazuva ekupa generic pakarepo-kuburitsa metformin.
Anenge ese Medicare uye zvirongwa zveinishuwarenzi zvichavhara generic metformin ER. Brand-zita Glucophage XR inogona kudhura kutenderera madhora makumi masere zvichienderana nekhemisi yaunoenda. Iine SingleCare koponi kadhi, generic metformin ER inogona kutengwa yakaderera kunge $ 4 yemazuva makumi matatu kupihwa kamwe-zuva nezuva metformin ER mapiritsi. Kunyangwe neinishuwarenzi, SingleCare inogona kukwanisa kupa mutengo wakaderera. Tarisa nekemisi yako kuti uone kana uchigona kutora mukana wekutora zvirinani neSingleCare.
Tora kadhi reSpecialCare rekutora kadhi
| Metformin | Metformin ER | |
| Kazhinji yakafukidzwa neinishuwarenzi? | Ehe | Ehe |
| Inowanzo kufukidzwa neMedare? | Ehe | Ehe |
| Standard muyero | 500 mg mapiritsi (huwandu hwemapiritsi makumi matanhatu) | 500 mg mapiritsi (huwandu hwemapiritsi makumi matatu) |
| Chaizvoizvo Medicare copay | $ 0- $ 8 | $ 0- $ 8 |
| SingleCare mutengo | $ 4 | $ 4 |
Zvakajairika mhedzisiro mhedzisiro yemetformin vs. metformin ER
Metformin inokonzeresa mhedzisiro inokanganisa gastrointestinal (GI) system. Izvi mhedzisiro inosanganisira manyoka, kuda kurutsa, kurutsa, gasi (flatulence), kuzvimba, uye kusagadzikana mudumbu kana kushungurudzika mudumbu. Metformin IR zvakare inowanzo kukonzera kuneta kana kushomeka kwesimba (asthenia) pamwe nemusoro.
Metformin ER ine mashoma mhedzisiro kana ichienzaniswa ne metformin. Mhedzisiro inowanzoitika inosanganisirwa ne metformin ER manyoka, kuda kurutsa, uye kurutsa. Metformin ER inogona zvakare kukonzera kupatira mune vamwe vanhu. Kunyangwe metformin ER inogona kukonzeresa mamwe maGI mhedzisiro senge indigestion uye flatulence, izvi mhedzisiro hazviitike sezvakawanda zvichienzaniswa neyakajairwa metformin.
Mimwe mhedzisiro mhedzisiro inogona kuitika ne metformin uye metformin ER inosanganisira dzungu, hura hwakareruka, uye kusagadzikana kwekuravira. Zvimwe zvakakomba mhedzisiro mhedzisiro yemetformin uye metformin ER inosanganisira kukuvara kwechiropa uye hypoglycemia (shuga shoma yeropa).
| Metformin | Metformin ER | |||
| Side Migumisiro | Zvinoshanda? | Kakawanda | Zvinoshanda? | Kakawanda |
| Manyoka | Ehe | 53% | Ehe | 10% |
| Kusvotwa kana kurutsa | Ehe | 26% | Ehe | 7% |
| Kubata ropa | Ehe | 12% | Ehe | 1% -5% |
| Asthenia | Ehe | 9% | Kwete | - |
| Kuzvidya mwoyo | Ehe | 7% | Ehe | 1% -5% |
| Kushungurudzika mudumbu | Ehe | 6% | Ehe | 1% -5% |
| Kutemwa nemusoro | Ehe | 6% | Ehe | 1% -5% |
| Kuzvimbirwa | Kwete | - | Ehe | 1% -5% |
| Edza kusagadzikana | Ehe | 1% -5% | Ehe | 1% -5% |
| Dzungu / musoro wakareruka | Ehe | 1% -5% | Ehe | 1% -5% |
Iri rinogona kunge risiri runyorwa rwakakwana. Bvunza chiremba wako kana wemishonga kuti uwane mhedzisiro.
Kwayaka: DailyMed ( Metformin ), Zuva Nezuva ( Metformin ER )
Kubatana kwemishonga kwemetformin vs. metformin ER
Metformin uye metformin ER inogona kusangana nemishonga yakati wandei. Kubatana kwezvinodhaka kazhinji kunoguma neshuga yeropa shanduko, njodzi yakawedzera ye lactic acidosis , kana kuunganidzwa kwemetformin muropa iyo inogona kuwedzera njodzi yemhedzisiro.
Kutora metformin nemishonga inonzi carbonic anhydrase inhibitors kunogona kuwedzera njodzi yeactic acidosis, iyo inogona kutyisidzira hupenyu kubva kune yakawanda lactate mumuviri. Iyi mishonga inosanganisira topiramate uye acetazolamide pakati pevamwe.
Zvinodhaka senge dolutegravir, cimetidine, uye ranolazine zvinogona kudzikisira kusabvumidzwa kwemetformin. Izvi zvinogona kukonzera kukwirira kwakanyanya kwemetformin muropa uye kuwedzera njodzi yezviitiko zvakashata.
Mimwe mishonga senge diuretics, corticosteroids, phenothiazines, estrogens, zvekudzivirira kubata mukanwa, uye calcium chiteshi blockers inogona kukanganisa kudzora glucose. Kutora chero ipi yemishonga iyi ne metformin kunogona kukonzera hyperglycemia (zvine ngozi shuga yeropa). Kushandisa insulin kana sulfonylurea kana glinide drug ine metformin kunogona kukonzera njodzi yeku hypoglycemia .
| Zvinodhaka | Kirasi Yezvinodhaka | Metformin | Metformin ER |
| Topiramate Acetazolamide Zonisamide Dichlorphenamide | Carbonic anhydrase inhibitors | Ehe | Ehe |
| Dolutegravir Cimetidine Vandetanib Ranolazine | Mishonga inoderedza kubviswa kwemetformin kubva mumuviri | Ehe | Ehe |
| Insulin | Insulin | Ehe | Ehe |
| Glimepiride Glipizide Glyburide Repaglinide Nateglinide | Insulin zvakavanzika | Ehe | Ehe |
| Hydrochlorothiazide Chlorthalidone Indapamide Furosemide Bumetanide Torsemide Ethacrynic asidhi | Diuretics | Ehe | Ehe |
| Prednisolone Prednisone Hydrocortisone Dexamethasone Fludrocortisone | Corticosteroids | Ehe | Ehe |
| Chlorpromazine Mesoridazine Prochlorperazine Thioridazine | Phenothiazines | Ehe | Ehe |
| Levothyroxine | Utachiona mishonga | Ehe | Ehe |
| Yakagadziriswa estrogens Ethinyl estradiol Levonorgestrel Norethindrone Desogestrel | Estrogens uye zvekudzivirira pamuromo | Ehe | Ehe |
| Phenytoin | Antiepileptic | Ehe | Ehe |
| Niacin | Nicotinic asidhi | Ehe | Ehe |
| Ephedrine | Sympathomimetic | Ehe | Ehe |
| Amlodipine Diltiazem Felodipine Nicardipine Nifedipine Verapamil | Calcium chiteshi blocker | Ehe | Ehe |
| Isoniazid | Mishonga inorwisa mabhakitiriya | Ehe | Ehe |
Izvi zvinogona kunge zvisiri runyorwa ruzere rwe zvese zvinobvira kusangana kwemishonga. Bvunza chiremba nemishonga yose yaungave uri kutora.
Yambiro dze metformin vs. metformin ER
Metformin inogona kukonzera lactic acidosis mune zvisingawanzoitika zviitiko. Lactic acidosis inoitika kana paine lactate yakawandisa muropa. Aya mamiriro anogona kukonzeresa kudzikira kweropa, hypothermia, uye kunyangwe rufu. Zvimwe zviratidzo zveactic acidosis zvinosanganisira kushomeka kusingajairiki, manyoka, kurwadziwa nemudumbu, uye kurwadza. Tsvaga kurapwa nekukurumidza kana iwe ukaratidza izvi zviratidzo.
Metformin inogona kuderera vhitamini B12 nhanho mumuviri. Nekufamba kwenguva izvi zvinogona kukonzera kushomeka kwevhitamini B12. Vitamin B12 mazinga anofanirwa kuongororwa ese makore maviri kusvika matatu paanotora metformin kwenguva refu.
Kunyangwe isingawanzoitika, metformin inogona kukonzera hypoglycemia kana ikatorwa ne insulin kana insulin secretagogue yakaita se glipizide kana repaglinide. Muzviitiko zvisingawanzoitika, metformin inogona kukonzera hypoglycemia painotorwa nedoro kana chikafu chisina kukwana.
Inowanzo bvunzwa mibvunzo nezve metformin vs. metformin ER
Chii chinonzi metformin?
Metformin imishonga inonyorwa inogamuchirwa kurapa rudzi rwechipiri chirwere cheshuga mellitus muvakuru nevana vane makore gumi zvichikwira. Pakarepo-kuburitswa metformin inowanzo kutorwa kaviri zuva nezuva nekudya. Inotaridzirwa semutsara wekutanga kurapwa kwechirwere cheshuga chechipiri kana ichibatanidzwa neyakafanira kudya uye kurovedza muviri .
Chii chinonzi metformin ER?
Metformin ER ndiyo yakawedzera-kuburitsa fomu yemetformin. Iyo inozivikanwawo nemazita ezita reGlucophage XR, Glumetza, kana Fortamet. Metformin ER inogara kwenguva yakareba kupfuura yakajairwa metformin uye ine mashoma mhedzisiro. Inotarisirwa kamwe chete zuva nezuva nekudya kwemanheru.
Metformin uye metformin ER zvakafanana here?
Kwete. Metformin uye metformin ER hazvina kufanana. Metformin ndiyo yekukurumidza-kuburitsa vhezheni nepo metformin ER iri yakawedzerwa-kuburitsa vhezheni. Metformin inogamuchirwa kurapa rudzi rwechipiri chirwere cheshuga muvakuru uye vana vane makore gumi zvichikwira apo metformin ER inogamuchirwa chete kurapa rudzi rwechipiri chirwere cheshuga muvakuru.
Metformin uye metformin ER iri nani here?
Metformin ER inoonekwa senge iri nani sarudzo nekuti inongoda kutorwa kamwe chete zuva nezuva. Izvo zvakafanana kana zvinoshanda kupfuura metformin uye kashoma kukonzeresa mamwe mhedzisiro.
Ndinogona here kushandisa metformin uye metformin ER ndichiri nepamuviri?
Metformin inogona kushandiswa panguva yekuzvitakura kana mabhenefiti akakunda njodzi. Zvidzidzo zvemhuka ratidza kuti hapana zvinokuvadza kune fetus. Zvisinei, njodzi yekuremara kwekuberekwa haigone kutarisirwa kunze. Taura nachiremba kuti uone kana metformin yakakodzera panguva yekuzvitakura kana kuyamwisa.
Ndinogona here kushandisa metformin uye metformin ER nedoro?
Izvo hazviwanzo kukurudzirwa kutora metformin kana metformin ER nedoro. Kunwa doro kunogona kuchinja huwandu hweshuga yeropa zvichikonzera kuwanda kwengozi yehyperglycemia kana hypoglycemia.
Zvinorevei metformin HCl ER zvinorevei?
Metformin HCl ER ine metformin hydrochloride mukuwedzera-kuburitsa kugadzirwa.
Metformin ER yakafanana neGlucophage XR?
Metformin ER ine zvakafanana zvinoshandiswa zvinoshandiswa seGlucophage XR. Metformin ER izita rakajairika reGlucophage XR.
