Latuda vs. Gonesa: Musiyano, kufanana, uye izvo zviri nani kwauri
Zvinodhaka Vs. ShamwariKuongorora kwemishonga & misiyano mikuru | Conditions kurapwa | Kubudirira | Inishuwarenzi kufukidza uye mutengo kuenzanisa | Zvimwe zvinokanganisa | Kubatana kwezvinodhaka | Yambiro | MIBVUNZO
Latuda (lurasidone) uye Abilify (aripiprazole) ndiwo mazita ekurapa mishonga inoshandiswa kurapa schizophrenia. Schizophrenia kusagadzikana kwepfungwa kunoonekwa nezviratidzo zvakadai sekunyepedzera, kuona zvisipo, uye kutaura zvisina hunhu kana maitiro. Mukuwedzera kune schizophrenia, Latuda uye Abilify inogona zvakare kubata mamwe mamiriro ehutano hwepfungwa.
Ose maviri Latuda uye Abilify anoiswa seatypical antipsychotic, kana yechipiri-chizvarwa antipsychotic. Ivo vanoshanda nenzira dzakafanana kubatsira kubatsira kudzikisa zviratidzo zvechichichiphrenia. Ipo nzira chaiyo yavanoshanda isingazivikanwe, iyi mishonga inorwisa kurwara nehukama inopindirana nedopamine uye serotonin receptors muuropi.
Ndeapi misiyano mikuru pakati peLatuda neAbilify?
Musiyano mukuru pakati peLatuda neAbilify ndeye iwo ane akasiyana anoshanda zvinoshandiswa. Latuda ine lurasidone uye Abilify ine aripiprazole.
Latuda yaive FDA yakatenderwa mu2010 kurapa schizophrenia uye bipolar kushushikana. Inowanikwa sehwendefa remuromo musimba re20 mg, 40 mg, 60 mg, 80 mg, uye 120 mg. Latuda inosvika pakakwirira mwero mumuviri mukati meye kusvika matatu awa. Latuda inowanzo kutanga pa20 kana 40 mg pazuva zvichienderana nemamiriro ari kurapwa, uye inofanirwa kutorwa nechikafu chekutora zvirinani .
Abilify yaive FDA yakatenderwa muna2002 kurapa schizophrenia uye mamwe mamiriro ehutano hwepfungwa, senge bipolar disorder, autistic kusagadzikana, uye chirwere cheTourette. Kubatsira kunowanikwa sehwendefa remuromo musimba re2 mg, 5 mg, 10 mg, 15 mg, 20 mg, uye 30 mg. Izvo zvinouyawo semuromo unopwanya piritsi, yemuromo mhinduro, uye jekiseni. Bvisa mapiritsi emuromo anosvika pakakwirira mumuviri mukati memaawa matatu kusvika mashanu mushure mekutonga, uye anogona kutorwa pamwe kana pasina chikafu.
| Misiyano mikuru pakati peLatuda neAbilify | ||
|---|---|---|
| Latuda | Gonesa | |
| Kirasi yemishonga | Antipsychotic | Antipsychotic |
| Brand / generic chinzvimbo | Brand uye generic vhezheni iripo | Brand uye generic vhezheni iripo |
| Chii chinonzi generic zita? | Lurasidone | Aripiprazole |
| Ndeapi mafomu (s) ayo mushonga unouya? | Hwendefa remuromo | Hwendefa remuromo Orally inoparadzanisa piritsi Oral solution Upfu kuti kuturika kuti intramuscular jekiseni |
| Ndeipi muyero wakajairwa? | Schizophrenia muvakuru: 40 kusvika 160 mg pazuva.Schizophrenia muvachiri kuyaruka (13 kusvika 17 makore ekuberekwa): 40-80 mg pazuva | Schizophrenia muvakuru: 10 kusvika 15 mg pazuva.Schizophrenia muvachiri kuyaruka (13 kusvika 17 makore ekuberekwa): 2 kusvika 10 mg pazuva |
| Yakareba sei iyo yekurapa? | Zvinosiyana: varwere vanofanirwa kuongororwa nguva nenguva | Zvinosiyana: varwere vanofanirwa kuongororwa nguva nenguva |
| Ndiani anowanzoshandisa mushonga? | Vakuru, vachiri kuyaruka, uye vana makore gumi zvichikwira (zvinoenderana nemamiriro ari kurapwa) | Vakuru, vachiri kuyaruka, uye vana makore matanhatu zvichikwira (zvinoenderana nemamiriro ari kurapwa) |
Mamiriro ezvinhu akarapwa naLatuda uye Abilify
Latuda inoshandiswa kurapa schizophrenia muvakuru uye vana vane makore gumi nematatu zvichikwira. Izvo zvakare zvakagamuchirwa kurapa kushushikana kwezvikamu zvinosangana ne bipolar I kusagadzikana muvakuru uye vana vane makore gumi nemakore nekure.
Abilify inoshandiswawo kurapa schizophrenia muvakuru nevana vane makore gumi nematatu zvichikwira. Nekudaro, kusiyana neLatuda, inobvumidzwa kurapa yakavhenganiswa kana manic episheni ane hukama ne bipolar I kusagadzikana muvakuru nevana vane makore gumi zvichikwira. Abilify inogona zvakare kubata chirwere cheTourette, kana Tourette's chirwere , uye kusagadzikana kunosangana ne autistic kusagadzikana. Kana uchinge wapiwa nehumwe hutachiona hweanodzvinyirira, Abilify inogona kubata zvakanyanya kushungurudzika kusagadzikana (MDD). Bvisa jekiseni FDA inogamuchirwa kurapa zviratidzo zvekushushikana kubva kuschizophrenia uye bipolar mania.
| Mamiriro | Latuda | Gonesa |
| Schizophrenia | Ehe | Ehe |
| Bipolar kusagadzikana | Ehe | Ehe |
| Huru kushungurudzika kusagadzikana | Kwete | Ehe |
| Autistic kusagadzikana | Kwete | Ehe |
| Tourette kusagadzikana | Kwete | Ehe |
Latuda kana Abilize inoshanda here?
Latuda uye Abilify ese ari maviri anoshanda mishonga yekurapa schizophrenia, yakakomba chirwere chepfungwa . Mushonga wakanakisa unoenderana nezvinhu zvakaita semamiriro ekurapwa, mhedzisiro, uye mutengo.
Imwe meta-ongororo yakafananidza antipsychotic senge lurasidone, olanzapine, quetiapine, risperidone, uye paliperidone. Vatsvagiri vakaona kuti lurasidone yaive yakafanana nemamwe antipsychotic yekurapa schizophrenia. Nekudaro, lurasidone yakawanikwa iine huremu hushoma uye njodzi yakaderera yemimwe mhedzisiro kana ichienzaniswa nemamwe maatipiki antipsychotic.
Imwe meta-ongororo kubva ku World Zvinyorwa zveBiological Psychiatry achifananidza lurasidone nemamwe antipsychotic ekurapa bipolar kushushikana. Kupfuura gumi akasiyana emakiriniki miedzo ine vanopfuura zviuru zvitanhatu zvevarwere vakaongororwa mukuwongorora. Antipsychotic, senge lurasidone, quetiapine, aripiprazole, olanzapine, uye ziprasidone, zvakaenzaniswa maererano nekuchengetedza pamwe nekubudirira. Chidzidzo ichi chakagumisa kuti lurasidone inogona kushanda zvakanyanya kupfuura aripiprazole uye ziprasidone, uye inogona kukonzeresa kushomeka uye kukotsira pane mamwe maantipsychotic.
Bvunza mupi wezvehutano nezvehutano hwakanakisisa iwe.
Kuvhavha uye mutengo wekuenzanisa weLatuda vs. Abilify
Iyo FDA yakabvumidza generic vhezheni yeLatuda. Nekudaro, iyo generic vhezheni inogona kana inogona kunge isingawanikwe parizvino pamusika. Semuchina wezita-mushonga, Latuda inogona kudhura kunyangwe neinishuwarenzi. Medicare uye zvirongwa zveinishuwarenzi zvinowanzo kufukidza Latuda, kunyangwe macopay anogona kusiyana pamarongero akasiyana. Mari yemari yeLatuda ndeye $ 1,783.52. Coupon reCustomCare rinogona kudzora mutengo kusvika pamadhora chiuru nemazana maviri.
Kubatsira kunowanikwa seyakajairika uye zita rezita mishonga. Mazhinji Medicare uye zvirongwa zveinishuwarenzi zvichafukidza Abilify. Kuenzaniswa neLatuda, Abilify inogona kunge iri isingadhuri kurapa sarudzo. Nekudaro, mutengo wemari unogona kuramba uchidhura pamadhora 1,059.99. Kadhi reSchoolCare rekudzikisira reAbilify rinogona kukwanisa kudzikisa mutengo kusvika pasi pe $ 100.
| Latuda | Gonesa | |
| Kazhinji yakafukidzwa neinishuwarenzi? | Ehe | Ehe |
| Inowanzo kufukidzwa neMedare Chikamu D? | Ehe | Ehe |
| Zvakawanda | Mahwendefa makumi matatu (40 mg) | Mahwendefa makumi matatu (5 mg) |
| Chaizvoizvo Medicare copay | $ 7– $ 46 | $ 3– $ 204 |
| SingleCare mutengo | $ 1,236 + | $ 65 + |
Zvakajairika mhedzisiro mhedzisiro yeLatuda vs. Abilify
Mhedzisiro yakajairika yeLatuda inosanganisira kurara, kusagadzikana kana kuda kufamba-famba (akathisia), kuda kurutsa, uye kurutsa. Mimwe mhedzisiro yeLatuda inogona kusanganisira kuomarara kwemhasuru, kudedera, uye kuwedzera uremu.
Mhedzisiro inowanzoitika yeAbilify inosanganisira kusvotwa, kurutsa, kunyorova kana kukotsira, dzungu, kuzvimbirwa, kurwadziwa nemusoro, kusaona zvakanaka, akathisia, uye kushaya hope. Mimwe mhedzisiro mhedzisiro yeAbilify inosanganisira kuomarara kwemhasuru uye kuwedzera uremu.
Ose maviri Latuda uye Abilify anogona kukonzera yakakwira ropa shuga uye cholesterol mazinga muropa. Zvakakomba mhedzisiro yemhedzisiro yeLatuda uye Abilify inogona kusanganisira yakachena chena masero eropa kuverenga, kubatwa, kudzikira kweropa (orthostatic hypotension), uye kusadzora kufamba kwemuviri (tardive dyskinesia).
Ona pazasi yemimwe mhedzisiro yeLatuda uye Abilify.
| Latuda | Gonesa | |||
| Side maitiro | Zvinoshanda? | Kakawanda | Zvinoshanda? | Kakawanda |
| Kukotsira | Ehe | 17% | Ehe | 5% |
| Akathisia | Ehe | 13% | Ehe | 13% |
| Nausea | Ehe | 10% | Ehe | gumi neshanu% |
| Kusvipa | Ehe | 8% | Ehe | gumi neimwe% |
| Kuzvidya mwoyo | Ehe | 6% | Ehe | 9% |
| Kusarara | Ehe | 5% | Ehe | 18% |
| Kufunganya | Ehe | 5% | Ehe | 17% |
| Dzungu | Ehe | 5% | Ehe | 3% |
| Kurera huremu | Ehe | 3% | Ehe | 3% |
| Kutambudzika shure | Ehe | 3% | Kwete | - |
| Kuona kwakashata | Ehe | * | Ehe | 3% |
| Muromo wakaoma | Ehe | * | Ehe | 5% |
| Kuzvimbirwa | Kwete | - | Ehe | gumi neimwe% |
| Kutemwa nemusoro | Kwete | - | Ehe | 10% |
| Kutambudzika kwemhasuru | Kwete | - | Ehe | piri% |
* haina kutaurwa
Kakawanda hakubvi pane data kubva kumusoro-kuenda-kumusoro kutongwa. Izvi zvinogona kunge zvisiri runyorwa ruzere rwemhedzisiro mhedzisiro inogona kuitika. Ndokumbira utarise kuna chiremba wako kana mupi wezvehutano kuti udzidze zvimwe.
Kwayaka: DailyMed ( Latuda ), Zuva Nezuva ( Gonesa )
Kubatana kwezvinodhaka kwaLatuda vs. Kubatsira
Latuda uye Abilify inonyanya kugadziriswa muchiropa neCYP3A4 enzyme. Kushandiswa kwavo kungangoda kudzivirirwa, kugadziridzwa, kana kuongororwa kana zvabatanidzwa nemishonga inoshanda seCYP3A4 inhibitors kana CYP3A4 inducers. Zvinodhaka zvinoshanda seCYP3A4 inhibitors, senge ketoconazole uye ritonavir, zvinogona kukonzera kuwanda kweLatuda kana Kubvisa uye kuwedzera njodzi yemhedzisiro. Zvinodhaka zvinoshanda seCYP3A4 inducers, senge rifampin uye carbamazepine, zvinogona kukonzera kudzikira kwenhanho dzeLatuda kana Kubvisa uye kudzikisira kushanda kweanorapa mapiritsi. Kubatanidza Abilify uye CYP2D6 inhibitors, senge quinidine uye fluoxetine, zvinogona kutungamira mukuwedzera Abilify mazinga uye mhedzisiro.
Iko kushandiswa kweLatuda uye Abilify kungangoda kuongororwa kana kudzivirirwa apo uchishandisa antihypertensive zvinodhaka kana benzodiazepines. Kutora iyi antipsychotic mishonga ine antihypertensive zvinodhaka zvinogona kuwedzera njodzi yekuderera kweropa. Benzodiazepines inogona kusanganisa iyo sedative mhedzisiro yeLatuda kana Abilify.
| Zvinodhaka | Kirasi yemishonga | Latuda | Gonesa |
| Ketoconazole Fluconazole Clarithromycin Erythromycin Ritonavir Diltiazem Verapamil | CYP3A4 inhibitors | Ehe | Ehe |
| Rifampin Phenytoin Carbamazepine Efavirenz Etravirine Wort St. | CYP3A4 inducers | Ehe | Ehe |
| Quinidine Fluoxetine Paroxetine | CYP2D6 inhibitors | Kwete | Ehe |
| Amlodipine Lisinopril Losartan | Antihypertensives | Ehe | Ehe |
| Alprazolam Diazepam Lorazepam | Benzodiazepines | Ehe | Ehe |
Bvunza nyanzvi yezvehutano kune kumwe kudyidzana kwezvinodhaka
Yambiro yeLatuda uye Abilify
Ose maviri Latuda uye Abilify anotakura nhema bhokisi yambiro. Kune njodzi yakawandisa yekufa uye dementia-inoenderana nepfungwa psychosis apo antipsychotic zvinodhaka zvinotorwa nevakuru. Pfungwa dzekuzviuraya uye hunhu zvakataurwawo muvana nevakuru vechidiki vachishandisa Latuda uye Abilify. Vechidiki varwere vangangoda kuongororwa nekuda kwekuwedzera kwezviratidzo kana shanduko mukuzvibata vachitora Latuda kana Abilify.
Kune njodzi yakawedzera yekusagadzikana kwecerebrovascular, senge sitiroko uye kurwisa kwekuschemic kurwisa, mune varwere vakwegura vane psychosis inoenderana nehutano hwepfungwa. Kutora Latuda kana Abilify zvakare kune njodzi yeku neuroleptic yakaipa malignant (NMS), iyo inogona kukonzera zviratidzo senge kupisa kwakanyanya, kuomarara kwemhasuru, kuvhiringidzika, uye shanduko mukurova kwemoyo. NMS mamiriro akakomba anoda kurapwa nekukurumidza.
Latuda uye Abilify zvinogona kukonzera shanduko yemagetsi, senge yakakwira mashuga eropa, kuwanda kwecholesterol, uye kuwedzera huremu. Iyi mishonga inogona zvakare kukonzera yakachena chena masero eropa kuverenga, kubatwa, uye kudzikira kweropa.
Bvunza mubatsiri wezvehutano kune zvimwe zvinonyeverwa uye matanho usati washandisa Latuda kana Abilify.
Inowanzo bvunzwa mibvunzo nezve Latuda vs. Abilify
Chii chinonzi Latuda?
Latuda inorwisa antipsychotic mishonga iyo inoshandiswa kurapa schizophrenia uye kushushikana kwezvikamu zvine chekuita nebipolar I kusagadzikana. Inowanikwa sehwendefa remuromo. Latuda inowanzo kutorwa kamwe pazuva nekudya.
Chii chinonzi Abilify?
Abilify ndeye atypical antipsychotic mishonga iyo inoshandiswa kurapa schizophrenia uye yakavhenganiswa kana manic episodes inosanganiswa ne bipolar I kusagadzikana. Abilify inobvumidzwawo kurapa chikuru kushungurudzika kusagadzikana, autistic kusagadzikana, uye chirwere cheTourette. Inowanikwa sehwendefa remuromo, muromo unoparadzanisa piritsi, yemuromo mhinduro, uye jekiseni. Kubatsira kunowanzo kutorwa kamwe chete pazuva kana pasina chikafu.
Latuda uye Abilize zvakafanana here?
Ose maLatuda uye Abilify ari atypical antipsychotic, kana yechipiri-chizvarwa antipsychotic, inogamuchirwa yekurapa schizophrenia. Nekudaro, ivo vanouya nenzira dzakasiyana dzedosi uye vane zviratidzo zvakasiyana kunze kweschizophrenia. Latuda inobata zvinoshungurudza zvikamu zve bipolar I kusagadzikana nepo Abilify inobata manic episodes ebipolar I kusagadzikana. Latuda inodawo kupihwa nechikafu nepo Abilize inogona kupihwa pamwe kana pasina chikafu.
Latuda kana Kugonesa zviri nani?
Latuda uye Abilify ese ari maviri anoshanda mishonga ye schizophrenia uye mamwe mamiriro ehutano hwepfungwa. Latuda inogona kunge ichishanda seAbilify uye imwe mishonga inorapa kurapa, uye inogona kukonzeresa mhedzisiro senge kurema kuwedzera . Zvimwe zvinhu zvinofanirwa kutariswa pakusarudza Latuda kana Abilify, senge mutengo. Bvunza mupi wezvehutano nezve yakanakisa yekurapa sarudzo yako.
Ini ndinogona kushandisa Latuda kana Abilify ndichiri nepamuviri?
Kutsvagurudza kunogumira pakushandiswa kwaLatuda uye Kubvisa paunenge uine nhumbu. Iyi antipsychotic mishonga inogona kukonzeresa extrapyramidal kana kubvisa zviratidzo mumaonate munguva yechitatu trimester. Ivo vanofanirwa kutorwa chete kana mabhenefiti akakunda njodzi. Bvunza wako mupi wezvehutano wezano rekurapa kuti uone kana uchifanira kushandisa Latuda kana Abilify uchiri nepamuviri.
Ndinogona here kushandisa Latuda kana Abilify nedoro?
Zvese zviri zviviri doro uye antipsychotic mishonga ine yepakati tsinga system (CNS) inoshungurudza mhedzisiro. Kutora antipsychotic nedoro kunogona kuwedzera njodzi yemamwe mhedzisiro, sekukotsira uye dzungu. Kunwa doro kunofanirwa kuve kushoma panguva yekutora Latuda kana Abilify.
Latuda inodzikamisa mamiriro kana antipsychotic?
Latuda haisi iyo inosimbisa mamiriro. Panzvimbo iyoyo, Latuda imushonga weantipsychotic iyo inogona kupihwa pamwe chete neyakagadzikana seLithobid (lithium) kana Depakene (valproic acid) yekurapa bipolar kushushikana. Mimwe mienzaniso yemaantipsychotic mishonga inosanganisira Invega (paliperidone), Seroquel (quetiapine), Zyprexa (olanzapine), Geodon (ziprasidone), Rexulti (brexpiprazole), uye Vraylar (cariprazine).
Kune here generic yeLatuda?
Iyo generic vhezheni yeLatuda yakagamuchirwa neDFA. Nekudaro, iyo generic vhezheni yeLatuda inogona kunge isati yave kuwanikwa pamusika. Vanogadzira generic Latuda vanosanganisira Accord Healthcare, Piramal Healthcare UK Limited, uye Sun Pharmaceutical Industries Ltd.
Chii chinoitika kana ukasatora Latuda nechikafu?
Latuda inogona kusashanda nemazvo painotorwa isina chikafu. Zvinokurudzirwa kutora Latuda nechikafu chinosvika mazana matatu nemazana emazana macalorie ekugona kunyatso. Iko kunwiwa kweLatuda kunowedzerwa kaviri kana mushonga wacho watorwa nechikafu.
