Gonesa vs.Rexulti: Misiyano, kufanana, uye izvo zviri nani kwauri
Zvinodhaka Vs. ShamwariKuongorora kwemishonga & misiyano mikuru | Conditions kurapwa | Kubudirira | Inishuwarenzi kufukidza uye mutengo kuenzanisa | Zvimwe zvinokanganisa | Kubatana kwezvinodhaka | Yambiro | MIBVUNZO
Abilify (aripiprazole) uye Rexulti (brexpiprazole) ese ari maviri antipyychotic. Ose madhiragi anotenderwa neUnited States Chikafu neDrug Administration (FDA). Abilify inowanikwawo mune yayo generic fomu ye aripiprazole. Rexulti parizvino haisi kuwanikwa mune generic fomu.
Atypical antipsychotic zvinodhaka zvinozivikanwa seyechipiri-chizvarwa antipsychotic. Chekutanga-chizvarwa antipsychotic, senge haloperidol, dzakagadzirwa muma1950. Iyi mishonga yaive nezvimwe zvakawanda mhedzisiro, senge extrapyramidal zviratidzo. Exrapyramidal zviratidzo zvinokonzerwa nekuvharirwa kwedopamine. Zviratidzo izvi zvinosanganisira kusagadzikana kwekufamba senge kusadzora uye kusazvibata kwemhasuru kufamba, kutadza kugara wakadzikama, kudedera, uye kushamisika kweziso kubhenekera.
Chechipiri-chizvarwa antipsychotic, senge Abilify uye Rexulti, vatsva uye vane mashoma extrapyramidal mhedzisiro. Nekuti ivo vari nani vanoregererwa, ndiwo marapirwo akasarudzika pamusoro pechizvarwa chekutanga antipsychotic.
Anopiki antipsychotic, senge Abilify uye Rexulti, anoshanda sei? Iyo chaiyo mashandiro ekuita haazivikanwe. Ivo vanofungidzirwa kuti vanoshanda paD2 dopamine receptors uye serotonin-5-HT1A uye 5-HT2A receptors muuropi, zvichibatsira zviratidzo zvechichichiphrenia kana zvimwe zvinetswa. Rexulti ine makemikari uye chimiro chakafanana neAbilify, izvo zvinoita kuti vafanane, asi kwete zvakangofanana. Enderera kuverenga kuti udzidze zvese nezve Abilify uye Rexulti.
Ndeupi mutsauko mukuru pakati peAbilify neRexulti?
Gonesa uye Rexulti ese ari maviri atypical antipsychotic mishonga. Abilify (aripiprazole) inowanikwa muchiratidzo uye generic fomu, uye Rexulti (brexpiprazole) parizvino inowanikwa chete muzita rezita. Mishonga yese iri miviri inowanikwa mufomu yepiritsi. Abilify inowanikwawo mune mamwe mafomu eiyero (ona chati pazasi kuti uwane ruzivo).
| Misiyano mikuru pakati peAbilify neRexulti | ||
|---|---|---|
| Gonesa | Rexulti | |
| Kirasi yemishonga | Atypical antipsychotic | Atypical antipsychotic |
| Brand / generic chinzvimbo | Brand uye generic | Brand |
| Chii chinonzi generic zita? | Aripiprazole | Wakaedza |
| Ndeapi mafomu (s) ayo mushonga unouya? | Piritsi, mapiritsi akaparara, mhinduro yemumuromo, jekiseni, jekiseni rinoshanda kwenguva refu (depot) | Hwendefa |
| Ndeipi muyero wakajairwa? | Zvinosiyana: vazhinji vakuru varwere vanotora 5 kusvika 15 mg nemuromo zuva rega rega | Zvinosiyana: vazhinji vakuru varwere vanotora 1 kusvika 4 mg nemuromo zuva rega rega |
| Yakareba sei iyo yekurapa? | Zvinosiyana: varwere vanofanirwa kuongororwa nguva nenguva | Zvinosiyana: varwere vanofanirwa kuongororwa nguva nenguva |
| Ndiani anowanzoshandisa mushonga? | Vakuru nevana (zera iro Abilise rinogona kushandiswa zvinoenderana nemamiriro) | Vakuru |
Unoda akanakisa mutengo paAbilify?
Saina kuti Abilify mutengo wekuzivisa uye uone kana mutengo uchinja!
Wana machenjedzo emitengo
Mamiriro ezvinhu anorapwa naAbilify naRexulti
Abilify uye Rexulti zvese zvinoratidzwa pakurapwa kwechichichiphrenia. Izvo zvese zviri zviviri zvinogamuchirwa seanogonesa kurapa (pamwe chete nemishonga yekudzvinyirira) yekurapa kweakanyanya kushushikana kwepfungwa (MDD).
Pamusoro pezvo, Abilify inogona kurapa bipolar I kusagadzikana (kurapa kwakanyanya kwemanic uye yakavhenganiswa zvikamu kana kurapwa kwekuchengetedza), kusagadzikana kweTourette, uye kusagadzikana nekuda kwe autistic kusagadzikana. Iyo jekiseni fomu yeAbilify inoshandiswa pakurapa kwakanyanya kwekushushikana kunokonzerwa neschizophrenia kana bipolar kusagadzikana.
| Mamiriro | Gonesa | Rexulti |
| Kurapa kwechichichiphrenia | Ehe | Ehe |
| Bipolar I kusagadzikana (kurapwa kwakanyanya uye kwekuchengetedza) | Ehe | Kwete |
| Adjunctive Therapy kune anodzvinyirira ekuora mwoyo | Ehe | Ehe |
| Kushatirwa kwakabatana ne autistic kusagadzikana | Ehe | Kwete |
| Kurapa kwechirwere cheTourette | Ehe | Kwete |
| Kurapa kwakasimba kwekushushikana nekuda kweschizophrenia kana bipolar kusagadzikana | Hongu (jekiseni fomu) | Kwete |
Kubatsira kana Rexulti kunoshanda here?
Pane dhata diki kwazvo kuenzanisa Abilify uye Rexulti zvakananga.
An chinyorwa muKurapa Kufambira Mberi muPsychopharmacology kwakatarisa dhata uye kuongorora ongororo (meta-ongororo). Vatsvakurudzi vakagumisa kuti Rexulti yakakonzera mashoma maratidziro eakathisia (kufamba kusagadzikana), kushaya hope, kusagadzikana, kusvotwa, kuwedzera uremu, uye kugadzikana nekuda kwechiitiko chayo pane mamwe ma receptors.
Iwo mafambiro-ane chekuita nemhedzisiro mhedzisiro yeAbilify, zvakadaro, yaitaridzika kunge yakapfava uye inotarisirwa nekuita kuti prescriber aderedze dosi. Iko kudhura kwakanyanya kwezita-zita Rexulti kunogona zvakare kuve chinhu kune vazhinji varwere, zvichienzaniswa nemutengo wakaderera weiyo generic Abilify.
Diki kudzidza akafananidza Abilify uye Rexulti mune varwere vane acute schizophrenia (muchipatara marongero) uye vakawana ese ari maviri madhiragi akafanana anoshanda. Varwere vanotora Rexulti vane ruzivo rwushoma extrapyramidal mhedzisiro. Izvo zvakakosha kuti utarise kukamurwa kwekuti chidzidzo ichi chaive chakavhurika-chinyorwa kudzidza (uko vese vaongorori nevarwere vaiziva mushonga wairwirwa nemurwere). Chidzidzo chakavhurika-chebhendi hachisi chepamusoro-soro sekudzidza kwakapofomara kwemaviri uko pasina rusarura.
Poshi kudzidza akatarisa padivi mhedzisiro yehuremu kubva kuna Abilify naRexulti. Chidzidzo chakapedzisa kuti ese ari maviri madhiragi aive nemhedzisiro yakafanana pahuremu hwemuviri (kuwedzera kweanosvika 5-10 lbs) mushure megore rimwe.
Mushonga unonyanya kushanda ndowaunoshanda zvirinani kwauri uye une mashoma (kana anoshivirira) mhedzisiro. Mubatsiri wako wezvehutano anogona kukubatsira kuti usarudze kana Abilify kana Rexulti zviri nani kwauri, uchifunga nezve ako mamiriro ezvehutano uye nhoroondo pamwe nemimwe mishonga yaunotora iyo inogona kudyidzana neAbilify kana Rexulti.
Unoda mutengo wakanakisa paRexulti?
Saina kuRexulti yemitengo yambiro uye uone kana mutengo uchinja!
Wana machenjedzo emitengo
Kuvhavha uye mutengo kuenzanisa kwe Abilify vs. Rexulti
Kubatsira kunowanzo kuvharwa nezvirongwa zveinishuwarenzi, Medicare Chikamu D, uye zvirongwa zveMedare zvinobatsira. Mari yekunze-kwehomwe yemwedzi mumwe chete yekuwaniswa mahwendefa e5 mg angave angangoita madhora mazana manomwe. Kadhi reSingleCare rinogona kuunza mutengo pasi kusvika pamadhora makumi mapfumbamwe nemasere.
Rexulti yakafukidzwa nezvizhinji, asi kwete zvese, zvirongwa zveinishuwarenzi, Medicare Chikamu D, uye zvirongwa zveMedicare Advantage. Kana iwe uchibhadhara kunze-kwehomwe, kupihwa kwemwedzi mumwe wemapiritsi maviri emamiriyoni ingangoita madhora mazana maviri nemakumi mana. Kushandisa CouponCare coupon kunounza mutengo unosvika madhora 198.
| Gonesa | Rexulti | |
| Kazhinji yakafukidzwa neinishuwarenzi? | Ehe | Hongu (kazhinji) |
| Inowanzo kufukidzwa neMedare Chikamu D? | Ehe | Ehe |
| Standard muyero | 30, 5 mg mahwendefa | 30, 2 mg mahwendefa |
| Chaizvoizvo Medicare copay | $ 1- $ 7 | $ 10- $ 41 |
| SingleCare mutengo | $ 98 + | $ 198 + |
Zvakajairika mhedzisiro mhedzisiro ye Abilify vs. Rexulti
Mhedzisiro inowanzoitika yeAbilify muvanhu vakuru ndeyekusvotwa, kurutsa, kuzvimbirwa, kutemwa nemusoro, dzungu, kushushikana, kushaya hope, akathisia (kusagadzikana kwekufamba nekuda kwemishonga yekurapa mishonga), uye kushungurudzika. Mimwe mhedzisiro inosanganisira indigestion, kuoma muromo, kurwadziwa nemazino, kusagadzikana mudumbu, kuneta, kuomarara, kugadzikana, kudedera, uye kukosora.
Mhedzisiro inowanzoitika yeRexulti yakanyorwa mumazita ekuraira ndeyemusoro, dzungu, kushushikana, akathisia, kuwedzera huremu, kuneta, nekushushikana / kusagadzikana.
Iyi rondedzero haisi rondedzero izere yemhedzisiro-mimwe mhedzisiro inogona kuitika. Bvunza wako wezvehutano wezvehutano kuti uwane yakazara runyorwa rweakashata mhedzisiro yeAbilify neRexulti.
| Gonesa | Rexulti | |||
| Side maitiro | Zvinoshanda? | Kakawanda | Zvinoshanda? | Kakawanda |
| Nausea | Ehe | gumi neshanu% | Ehe | ≥1% |
| Kusvipa | Ehe | gumi neimwe% | Kwete | - |
| Kuzvimbirwa | Ehe | gumi neimwe% | Ehe | piri% |
| Kutemwa nemusoro | Ehe | 27% | Ehe | 7% |
| Dzungu | Ehe | 10% | Ehe | 3% |
| Kufunganya | Ehe | 17% | Ehe | 3% |
| Kusarara | Ehe | 18% | Ehe | ≥1% |
| Akathisia | Ehe | 13% | Ehe | 9% |
| Kusagadzikana / kusagadzikana | Ehe | 19% | Ehe | 3% |
| Kuneta | Ehe | 6% | Ehe | 3% |
| Kurera huremu | Ehe | piri% | Ehe | 7% |
Kwayaka: DailyMed ( Gonesa ), Zuva Nezuva ( Rexulti )
Kudyidzana kwemishonga ye Abilify vs. Rexulti
Usatore Abilify uye Rexulti nedoro kana mishonga inokonzeresa central nervous system (CNS) kushushikana. Zvimwe zvinowedzera zvinogona kuitika, senge dzungu rakawandisa, kukotsira, uye kukanganisika kwepfungwa, zvichikonzera tsaona dzinouraya. Kumwe kudyidzana kwezvinodhaka kunogona kusanganisira hypoventilation (iyo inogona kutyisidzira hupenyu), kuderera kweropa, kana kuwedzera kwezviratidzo zve extrapyramidal (zvinokonzeresa kufamba kwekushushikana nezvinodhaka, zvichikonzera kudedera, kuomarara, uye kufamba kunononoka).
Kubatsira kana Rexulti, pamwe chete nemishonga yeropa, zvinogona kukonzera kuderera kweropa. Bvunza yako prescriber kana iwe uine yakakwira BP uye utore mushonga weBP yako.
Gonesa uye Rexulti ese ari maviri anopindirana nemishonga inogadziriswa nemamwe maenzymes. Zvinodhaka zvinodzivisa enzymes zvinogona kuwedzera mazinga eAbilify kana Rexulti. Zvinodhaka zvinokonzeresa maenzymes zvinogona kudzikisa mazinga eAbilify kana Rexulti. Kana kusangana kwemishonga kusingagoni kudzivirirwa, muchengeti anofanira kugadzirisa dosing.
Kumwe kudyidzana kwezvinodhaka kunogona kuitika. Bvunza wako mupi wezvehutano kuti uwane izere runyorwa rwekudyidzana kwezvinodhaka usati watora Abilify kana Rexulti.
| Zvinodhaka | Kirasi Yezvinodhaka | Inopindirana neAbilify? | Inopindirana naRexulti? |
| Doro | Doro | Ehe | Ehe |
| Ropa rekumanikidza mishonga | Antihypertensives | Ehe | Ehe |
| Carbamazepine Divalproex sodium Gabapentin Lamotrigine Levetiracetam Phenobarbital Phenytoin Pregabalin Topiramate | Anticonvulsants | Ehe | Ehe |
| Olanzapine Quetiapine Risperidone Ziprasidone | Antipsychotic | Ehe | Ehe |
| Amitriptyline Citalopram Desvenlafaxine Duloxetine Escitalopram Fluoxetine Fluvoxamine Nortriptyline Paroxetine Phenelzine Rasagiline Sertraline Tranylcypromine Venlafaxine | Zvinodzvinyirira | Ehe | Ehe |
| Codeine Fentanyl Hydrocodone Meperidine Methadone Morphine Oxycodone Tramadol | Kurwadziwa kweopioid kunodzora | Ehe | Ehe |
| Alprazolam Clonazepam Diazepam Lorazepam Temazepam | Benzodiazepines | Ehe | Ehe |
| Baclofen Carisoprodol Cyclobenzaprine Metaxalone | Tsandanyama dzinozorodza | Ehe | Ehe |
| Clarithromycin Itraconazole Ketoconazole | Inhibitors ye enzyme CYP3A4 | Ehe | Ehe |
| Fluoxetine Paroxetine Quinidine | Inhibitors ye enzyme CYP2D6 | Ehe | Ehe |
| Carbamazepine Rifampin Wort St. | Inokurudzira enzyme CYP3A4 | Ehe | Ehe |
Yambiro dzeKubvisa uye Rexulti
Nekuti Abilify neRexulti zvakafanana, vane yambiro zvakafanana:
- Iko kune nhema nhema yambiro, inova yambiro yakasimba inodiwa neDFA.
- Abilify uye Rexulti havabvumidzwe kurapa varwere vakura vane psychosis-inosangana nepfungwa. Varwere ava vari pangozi yekufa. Anodzvinyirira mishonga inowedzera njodzi yekuzviuraya pfungwa uye hunhu mune varwere makore makumi maviri nemana uye vadiki. Pedyo tarisa varwere veese mazera vanotora mishonga yekudzvinyirira yekuwedzera kushungurudzika, shanduko mukuzvibata, uye kuzviuraya pfungwa / maitiro.
Dzimwe yambiro dzeAbilify neRexulti dzinosanganisira:
- Iko kune kuwedzera kwezviitiko zvezviitiko zvecerebrovascular, senge sitiroko kana kushomeka kwechischemic kurwisa, mune vakwegura varwere vane chirwere chepfungwa chakanangana neundangariro.
- Kana murwere achikura neuroleptic yakaipa malignant (inogona kuuraya), nekukurumidza misa Abilify kana Rexulti uye wongorora murwere. Zviratidzo nezviratidzo zveeuroleptic malignant syndrome zvinosanganisira kupisa muviri, kushanduka kwehutano hwepfungwa, kuomarara, uye kurova kwemoyo kana shanduko yeropa.
- Kana murwere akavamba tardive dyskinesia (isingabatsiri, inodzokorora kufamba senge grimacing kana ziso kubheneka), rega Abilify kana Rexulti kana zvakakodzera.
- Atypical antipsychotic inogona kukonzera shanduko yemagetsi, kusanganisira kuwedzerwa shuga yeropa / chirwere cheshuga, kuwedzera cholesterol, uye kuwedzera huremu. Tarisa varwere pane shanduko idzi.
- Kubatsira kana Rexulti kunogona kukonzera kubhejera kwehutachiona uye mamwe maitiro ekumanikidza (kukurudzira kutenga, kunwa doro, uye kuita bonde). Aya maitiro anogona kuda dosi yakaderera kana kuregedza kwechirwere.
- Chengetedza kurova kwemoyo uye BP. Orthostatic hypotension (yakaderera BP kana iwe uchisimuka) kana kufenda kunogona kuitika.
- Kuwa kunotungamira mukukuvara uye kutsemuka kunogona kuitika. Anopa hutano anofanirwa kupedzisa kuwira kwenjodzi paanotanga mushonga uye nekudzokorora.
- Matambudziko eesophageal uye chishuwo zvinogona kuitika. Shandisa nekuchenjerera kune varwere vari panjodzi yekuda.
- Shanduko mune chena yeropa masero kuverenga anogona kuitika. Kuzara kuwanda kweropa kunofanirwa kuongororwa kazhinji mukati memwedzi mishoma yekutanga kune varwere vane nhoroondo yakaderera chena masero eropa kuverenga.
- Shandisa Abilify kana Rexulti nokungwarira mune varwere vane nhoroondo yekubatwa.
- Chenjerera pakutyaira kana kushandisa michina kusvika iwe waziva kuti Abilify kana Rexulti inokukanganisa sei.
- Kune njodzi yakakura yekuzviuraya kune varwere vane schizophrenia uye bipolar kusagadzikana. Nyatso tarisa varwere ava.
- Nekuda kwekugona kwekudyidzana kwezvinodhaka, zivisa waunonyorera nezve chero mimwe mishonga yaunotora, zvese zvinyorerwo uye nepamusoro-pekutengesa.
- Dzivisa kupisa uye kupera mvura.
- Zivisa mupi wako wezvehutano kana iwe ukava nepamuviri uchitora Abilify kana Rexulti. Iyi mishonga inogona kukonzera extrapyramidal kana kubvisa zviratidzo mune neonate.
Inowanzo bvunzwa mibvunzo nezve Abilify vs. Rexulti
Chii chinonzi Abilify?
Abilify (aripiprazole) inorwisa antipsychotic, inowanikwa mu brand uye generic. Abilify inoshandiswa kurapa schizophrenia, kushushikana (kwakabatana nemushonga unodzvinyirira), bipolar I kusagadzikana, kusagadzikana kweTourette, kusagadzikana kunokonzerwa nehutachiona, uye kushungurudzika nekuda kweschizophrenia kana bipolar kusagadzikana.
Chii chinonzi Rexulti?
Rexulti (brexpiprazole) inorwisa antipsychotic, inowanikwa muzita rezita. Inoshandiswa kurapa kushushikana (pamwe chete neanodzvinyirira mishonga) uye schizophrenia.
Kugonesa uye Rexulti zvakafanana here?
Mishonga iyi miviri yakafanana nemakemikari uye chizvarwa chechipiri, atypical antipsychotic. Ivo vane zvimwe zvakafanana uye zvimwe misiyano, yakatsanangurwa mune ruzivo pamusoro.
Kugonesa kana Rexulti zvirinani?
Iko kune diki data kuenzanisa iyo miviri mishonga. Kuti ive FDA inogamuchirwa, ese madhiragi akaitwa kliniki miedzo yekubudirira uye kuchengetedzeka. Wako wekuchengeta hutano anogona kusarudza kana Abilify kana Rexulti iri nani kwauri zvichibva pahutano hwako, nhoroondo, uye mimwe mishonga yaunotora iyo inogona kuwirirana neAbilify kana Rexulti.
Ndinogona here kushandisa Abilify kana Rexulti ndichiri nepamuviri?
Neonates inoratidzwa kune atypical antipsychotic panguva yechitatu trimester yekuzvitakura iri panjodzi yekuwedzera yezviratidzo zve extrapyramidal (zvimwe zvinoda kuwedzerwa kuchipatara) uye zviratidzo zvekusiya mushure mekusununguka.
Kune njodzi nekushandisa iyo mishonga mukuzvitakura, uye kune njodzi dzekusarapa hutano hwepfungwa zvakare. Bvunza wako mupi wezvehutano nezvezvehutano. Kana iwe uri kutotora Abilify kana Rexulti uye uone kuti iwe une pamuviri, bata wako mupi wezvehutano.
Iyo National Pregnancy Registry yePsychiatric Mishonga inoongorora zvabuda pamuviri mune varwere vanotora mishonga yepfungwa vachiri nepamuviri.
Ndinogona here kushandisa Abilify kana Rexulti nedoro?
Kwete. Haufanire kunwa doro kana ukatora Abilify kana Rexulti. Iko kusanganisa kunogona kuwedzera njodzi ye CNS kushushikana (yakawandisa sedation, psychomotor kukanganisika, izvo zvinogona kukonzeresa tsaona) uye mweya wekufema (kufema kunonoka kana kutomira) uye yakaderera BP.
Rexulti inowedzera dopamine here?
Atypical antipsychotic saRexulti (uye Abilify) vane chikamu cheagonist chiitiko pane iyo D2 dopamine receptors. Aagonist akasarudzika zvinoreva kuti mushonga unosunga kune unogamuchira uye unomugonesa, asi unongoshanda zvishoma (uchienzaniswa neagonist). Nekudaro, iyi mishonga inokamuranisa dopamine receptors, iyo inowedzera mwero wedopamine. Iyi mishonga inoshandawo pane serotonin receptors.
Rexulti antipsychotic?
Ehe. Rexulti chizvarwa chechipiri antipsychotic. Chechipiri-chizvarwa antipsychotic nyowani uye chinokonzeresa mashoma mhedzisiro pane yekutanga-chizvarwa antipsychotic. Kunze kwekudzikisira uye Rexulti, mamwe echipiri-chizvarwa antipsychotic anosanganisira:
- Geodon (ziprasidone)
- Risperdal (risperidone)
- Seroquel (quetiapine)
- Latuda (lurasidone)
- Vraylar (cariprazine)
- Zyprexa (olanzapine)
- Clozaril (clozapine) yakarambidza kugoverwa muUS nekuda kwemhedzisiro yayo yakaipa.
Rexulti inobatsira kunetseka here?
Rexulti parizvino yakatenderwa schizophrenia uye kushushikana (pamwe chete neanodzvinyirira). Imwe fundo akatarisa varwere vane kushushikana uye zviratidzo zvekushushikana uye vakawana Rexulti kubatsira zviratidzo zvekushushikana (uye zvaibvumidzwa zvakanaka) kune varwere vane kushushikana. Varwere vakatora Rexulti pamwe chete neanodzvinyirira kana uyo anodzvinyirira ega asina kubatsira. Bvunza wako mupi wezvehutano kana iwe uchinetseka. Iye kana iye anogona kusarudza iwo marapirwo akakodzera iwe.
