Trintellix vs.Viibryd: Misiyano, kufanana, uye izvo zviri nani kwauri
Zvinodhaka Vs. ShamwariKuongorora kwezvinodhaka & misiyano mikuru | Conditions kurapwa | Kubudirira | Inishuwarenzi kufukidza uye mutengo kuenzanisa | Zvimwe zvinokanganisa | Kubatana kwezvinodhaka | Yambiro | MIBVUNZO
Vanopfuura mamirioni gumi nemashanu vakuru veAmerica kuora mwoyo (chikuru kushungurudzika kusagadzikana-MDD). Zviitiko zvechangobva kuitika, senge denda re COVID-19, rave sosi inoshamisa yekushushikana, ichikanganisa hutano hwepfungwa hwevanhu vazhinji.
Trintellix (vortioxetine) uye Viibryd (vilazodone) mishonga yekudzvinyirira. Mishonga yese iri miviri inogamuchirwa neUnited States Chikafu neDrug Administration (FDA) uye inowanikwa nachiremba. Takeda Pharmaceuticals, Inc. inogadzira Trintellix; Allergan, Inc. inogadzira Viibryd. Trintellix kana Viibryd inogona kushandiswa mukubatana ne psychotherapy nachiremba wepfungwa kana chiremba wepfungwa.
Trintellix uye Viibryd chikamu cheboka remishonga inonzi inosarudza serotonin reuptake inhibitors (SSRIs). Iyo antidipressant mhedzisiro inoitika apo SSRIs inowedzera maserotonin mazinga muuropi, zvichibatsira kusimudzira kushushikana zviratidzo. Ose madhiragi ane chimwe chiitiko pane serotonin receptors, asi kukosha kweichi chiitiko chekuwedzera hachizivikanwe kana kunzwisiswa. Neichi chikonzero, ivo dzimwe nguva vanonzi sevanodzvinyirira antidepressants kana serotonin modulators.
Ndeupi mutsauko mukuru pakati peTrintellix neViibryd?
Trintellix (vortioxetine) mushonga weSSRI. Iyo zvakare yakarongedzwa se serotonin modulator kana atypical antidepressant. Trintellix inowanikwa muzita rezita chete, mune fomu yepiritsi. Trintellix inogona kushandiswa muvakuru chete-haina kumbodzidziswa muvana. (Cherekedza: Trintellix pakutanga yainzi Brintellix, asi iyo zita rakashandurwa kudzivirira kuvhiringidzika naBrilinta, mushonga unodzivirira.)
Viibryd (vilazodone) zvakare iri SSRI mishonga inowanikwa muzita-zita, piritsi fomu. SaTrintellix, Viibryd inosanganisirwa se serotonin modulator kana atypical antidepressant. Viibryd haina kubvumidzwa kuti ishandiswe muvana. Iyo inongoratidzwa chete kuti ishandiswe muvakuru.
| Misiyano mikuru pakati peTrintellix neViibryd | ||
|---|---|---|
| Trintellix | Viibryd | |
| Kirasi yemishonga | SSRI (inosarudza serotonin reuptake inhibitor) / atypical antidepressant / serotonin modulator | SSRI (inosarudza serotonin reuptake inhibitor) / atypical antidepressant / serotonin modulator |
| Brand / generic chinzvimbo | Brand | Brand |
| Chii chinonzi generic zita? | Vortioxetine | Vilazodone |
| Ndeapi mafomu (s) ayo mushonga unouya? | Hwendefa | Hwendefa |
| Ndeipi muyero wakajairwa? | Kutanga pa10 mg pazuva, wobva wawedzera kusvika ku20 mg pazuva kana uchiregererwa. | Tanga pa 10 mg pazuva kwemazuva manomwe, wobva wawedzera kusvika 20 mg pazuva kana zvichidikanwa. Tora nechikafu. |
| Inguva yakareba sei kurapwa kwacho? | Zvinosiyana | Zvinosiyana |
| Ndiani anowanzoshandisa mushonga? | Vakuru | Vakuru |
Mamiriro ezvinhu akarapwa naTrintellix naViibryd
Trintellix neViibryd zvese zvinoratidzwa kurapa MDD, kana kushushikana kukuru kwekushushikana (kushushikana kukuru), muvanhu vakuru. Hapana mushonga unobvumidzwa kushandiswa muvarwere vevana.
Trintellix kana Viibryd dzimwe nguva zvinopihwa off-label yeakajairika kunetseka kusagadzikana kana mamwe mamiriro.
| Mamiriro | Trintellix | Viibryd |
| Major kushungurudzika kusagadzikana (MDD) muvakuru | Ehe | Ehe |
| Chirwere chekuzvidya mwoyo | Kunze-chitaridzi | Kunze-chitaridzi |
Trintellix kana Viibryd inoshanda here?
Imwe fundo akatarisa makumi maviri nemashanu mishonga yekudzvinyirira, kusanganisira Trintellix naViibryd. Chidzidzo chacho chakawana Trintellix kuva imwe yeanoshanda zvakanyanya uye ari nani-anoshivirira mishonga yekudzvinyirira. Pane dhata diki kwazvo uchienzanisa mishonga miviri musoro nemusoro.
Mushonga unonyanya kushanda kwauri unogona kungotariswa nemupi wako wezvehutano, uyo anogona kufunga nezve ako mamiriro ezvehutano uye nhoroondo, uye chero mishonga yaunotora iyo inogona kusangana naTrintellix kana Viibryd.
Kuvhavha uye mutengo kuenzanisa kweTrintellix vs.Viibryd
Trintellix yakafukidzwa neinishuwarenzi yakawanda uye zvirongwa zveMedicare zvekunyora. Iko-kwe-muhomwe mutengo uri kutenderera madhora mazana mashanu pamakumi matatu, makumi maviri emepiritsi. Kadhi reSingleCare remahara rinogona kudzikisa mutengo kusvika pamadhora mazana matatu nemakumi matatu nemashanu.
Yakawanda inishuwarenzi uye Medicare mapiritsi ekurapa anovhara Viibryd. Kunze kwehomwe mutengo wemakumi matatu, makumi maviri emepiritsi mg anogona kuita madhora mazana mana. Nekadhi reSingleCare remahara iwe unogona kubhadhara mari inosvika madhora mazana maviri nemakumi masere nemasere pane ma pharmacy ari kutora chikamu.
Zvirongwa zveinishuwarenzi zvinosiyana. Bata kambani yako yeinishuwarenzi kuti uwane-kusvika-zuva ruzivo rweinishuwarenzi.
| Trintellix | Viibryd | |
| Kazhinji yakafukidzwa neinishuwarenzi? | Ehe | Ehe |
| Inowanzo kufukidzwa neMedare Chikamu D? | Ehe | Ehe |
| Standard muyero | 30, 20 mg mahwendefa | 30, 20 mg mahwendefa |
| Chaizvoizvo Medicare copay | $ 3- $ 14 | $ 1- $ 10 |
| SingleCare mutengo | $ 345 + | $ 278 + |
Zvakajairika mhedzisiro mhedzisiro yeTrintellix vs.Viibryd
Rutivi rwakanyanya kuzivikanwa rweTrintellix kushungurudza. Iyi svumbunuro inowanzo kuve yakapfava kusvika pakati nepakati uye inogara kweanenge mavhiki maviri. Zvimwe zviitiko zvinowanzoitika zvakashata zveTrintellix zvinosanganisira bonde mhedzisiro, kusvotwa, kuzvimbirwa, kurutsa, manyoka, kuoma muromo, uye dzungu.
Mhedzisiro inowanzoitika yeViibryd manyoka, kuda kurutsa, kurutsa, uye kushaya hope.
Nechirevo chega chega chitsva kana chakazadzwa cheTrintellix kana Viibryd, iwe unogashira gwara rekurapa iro rinokurukura mhedzisiro, yambiro uye rumwe ruzivo rwakakosha
Iyi haisi rondedzero izere yemhedzisiro. Mimwe mhedzisiro yakaipa inogona kuitika. Bvunza wako mupi wezvehutano kuti uwane izere rondedzero yemhedzisiro mhedzisiro.
| Trintellix * | Viibryd | |||
| Side maitiro | Zvinoshanda? | Kakawanda | Zvinoshanda? | Kakawanda |
| Kutemwa nemusoro | Ehe | % haina kutaurwa | Ehe | gumi neshanu% |
| Nausea | Ehe | 21% -32% | Ehe | 22% |
| Kusvipa | Ehe | 5% -6% | Ehe | 4% |
| Ejaculation kusagadzikana / kusagadzikana pabonde | Ehe | 16% -34% | Ehe | 1% -3% |
| Manyoka | Ehe | 7% -10% | Ehe | 26% |
| Kuzvimbirwa | Ehe | 3% -6% | Kwete | - |
| Muromo wakaoma | Ehe | 6% -8% | Ehe | 8% |
| Kukotsira | Kwete | - | Ehe | 4% |
| Dzungu | Ehe | 6% -9% | Ehe | 6% |
| Kusarara | Kwete | - | Ehe | 7% |
| Kurera huremu | Ehe | % haina kutaurwa asi inotaura kuti hapana chakakosha pahuremu hwemuviri | Ehe | 1% -2% |
* mhedzisiro inoenderana nedosi
Kwayaka: DailyMed ( Trintellix ), Zuva Nezuva ( Viibryd )
Kubatana kwezvinodhaka zveTrintellix vs.Viibryd
Nekuti ese ari maviri madhiragi ari muchikamu chimwe chete, ane kusangana kwakafanana kwezvinodhaka.
MAOI (monoamine oxidase inhibitors) inofambidzana naTrintellix neViibryd. Kushandisa kwavo kunofanirwa kupatsanurwa nemazuva gumi nemana nemana nemasere, zvichienderana nehurongwa hwemunhu mumwechete Kubatanidza MAOI neTrintellix kana Viibryd kunowedzera njodzi ye serotonin chirwere , hupenyu hunotyisidzira hupenyu nekuda kwekuwedzera serotonin.
Triptans senge Imitrex (sumatriptan), uye zvimwe zvinodzvinyirira, senge Prozac kana Cymbalta, hazvifanirwe kusanganiswa neTrintellix kana Viibryd nekuda kwenjodzi yeserotonin syndrome.
Iyo yekudzvinyirira inodzvinyirira dextromethorphan (inowanikwa muRobitussin-DM pamwe nezvimwe zvakawanda zvekukosora uye zvigadzirwa zvinotonhora) inofanirwa kudzivirirwa nekuti inogona zvakare kukonzera serotonin syndrome kana ichibatanidzwa neTrintellix kana Viibryd.
Mimwe mishonga inogona kubatana naTrintellix kana Viibryd inosanganisira asiri-steroidal anti-anogumbura zvinodhaka (NSAIDs) senge aspirin kana ibuprofen, uye anticoagulants (ropa rakatetepa) sewarfarin. Dzivisa doro kana uchitora Trintellix kana Viibryd.
Iri harisi runyorwa ruzere rwekubatana kwezvinodhaka. Bvunza wako mupi wezvehutano kuti uwane izere runyorwa rwekudyidzana kwezvinodhaka.
| Zvinodhaka | Kirasi yemishonga | Trintellix | Viibryd |
| Phenelzine Rasagiline Selegiline Tranylcypromine | MAOI | Ehe | Ehe |
| Doro | Doro | Ehe | Ehe |
| Rizatriptan Sumatriptan Zolmitriptan | Triptans | Ehe | Ehe |
| Wort St. | Kuwedzera | Ehe | Ehe |
| Warfarin | Anticoagulant | Ehe | Ehe |
| Codeine Hydrocodone Morphine Oxycodone Tramadol | Opioid | Ehe | Ehe |
| Dextromethorphan (mune akawanda chikosoro uye zvigadzirwa zvinotonhora) | Kukosora kudzvinyirira | Ehe | Ehe |
| Aspirin Ibuprofen Meloxicam Nabumetone Naproxen | NSAIDs | Ehe | Ehe |
| Desvenlafaxine Duloxetine Venlafaxine | SNRI mishonga yekudzvinyirira | Ehe | Ehe |
| Amitriptyline Desipramine Imipramine Nortriptyline | Tricyclic antidepressants | Ehe | Ehe |
| Alprazolam Clonazepam Diazepam | Benzodiazepines | Kwete | Ehe |
| Digoxin | Cardiac glycoside | Kwete | Ehe |
| Carbamazepine Phenytoin Rifampin | Yakasimba inducers ye enzyme cytochrome P 450 3A4 | Ehe | Ehe |
| Clarithromycin Itraconazole Ketoconazole | Simba inhibitors ye enzyme cytochrome P 450 3A4 | Kwete | Ehe |
Yambiro yaTrintellix uye Viibryd
Ese SSRIs, kusanganisira Trintellix neViibryd, vane nhema bhokisi yambiro (iyo yambiro yakasimba inodiwa neDFA) yekuzviuraya. Vana, vachiri kuyaruka, uye vechidiki (kusvika pamakore makumi maviri nemana) vanotora mishonga yekudzvinyirira vane njodzi yekuzviuraya nemafambiro. Varwere vese pa mishonga inodzvinyirira inofanira kunyatsoongororwa.
Dzimwe yambiro dzinosanganisira:
- Serotonin syndrome ndeyekutyisidzira hupenyu kunokonzerwa neserotonin yakawandisa. Varwere vanotora Trintellix kana Viibryd vanofanirwa kuongororwa nezviratidzo nezviratidzo zveSerotonin syndrome, kusanganisira kufungidzira, kufenda, kushanduka kweropa, nekushungurudzika. Varwere vanofanirwa kutsvaga kurapwa kwekukurumidza kana zviratidzo zvikaitika. Mimwe mishonga inowedzera serotonin mazinga (triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, buspirone, dextromethorphan, amphetamines, St.
- SSRIs inogona kuwedzera njodzi yekubuda ropa, uye njodzi inowedzera nekushandisa pamwe chete kweaspirini, NSAID, kana warfarin.
- Kushanda kwemania kana hypomania kunogona kuitika. Mune varwere vane bipolar kusagadzikana, antidepressant inogona kukonzeresa yakavhenganiswa / manic episode.
- Dzivisa SSRIs kana kushandisa nekuchenjerera kune varwere vane isina kurapwa maatomiki madiki angles (angle-kuvhara glaucoma). Kumbira mupiki wako wezvehutano kana iwe uri panjodzi.
- Hyponatremia (yakaderera sodium mazinga) nekuda kwechirwere cheasina kukodzera antidiuretic hormone secretion (SIADH) inogona kuitika. Varwere vanogona kurwadziwa nemusoro, kunetseka kuisa pfungwa, kukanganisika kwendangariro, kuvhiringidzika, kushaya simba, uye kusadzikama, pamwe zvichitungamira kudonha. Varwere vanofanirwa kutsvaga kurapwa nechimbichimbi kana zviratidzo zvikaitika uye vorega SSRI.
- Kana uchirega Trintellix kana Viibryd, mushonga unofanirwa kutapurwa zvishoma nezvishoma kudzivirira zviratidzo zvekubvisa sengekutsamwa, kusagadzikana, kuvhiringidzika, kutemwa nemusoro, uye kugwinha. Usamise nechimbichimbi kutora Trintellix kana Viibryd. Mubatsiri wako wezvehutano anogona kukuraira iwe nenzira yakanakisa yekumisa Trintellix kana Viibryd.
- Usatyaire (kana kushandisa michina) kusvikira iwe waziva kuti Trintellix kana Viibryd zvinokubata sei.
- Kana iwe uine nhoroondo yekubatwa, taura nemupi wako wezvehutano nezve kushandisa Trintellix kana Viibryd.
- Muzviitiko zvisingawanzoitika, zvinowanzoitika kuerekana zvaitika. Kana iwe uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge
Trintellix kana Viibryd inongofanirwa kushandiswa mukuzvitakura kana rubatsiro kuna amai rukuru kudarika njodzi kumwana. Kumisa mishonga kunogona kukonzera kudzokazve kwekushushikana kana kushushikana. Naizvozvo, varwere vanofanirwa kuongororwa pane imwe nyaya-ne-kesi hwaro. Mutapi wako wezvehutano anogona kuyera njodzi nekukanganisa kushandisa SSRI panguva yekuzvitakura. Neonates yakaratidzwa kune SSRIs mune yechitatu trimester yakagadzira matambudziko anoda kugara kwenguva refu muchipatara, rutsigiro rwekufema, uye kudya kwepombi. Kana iwe uchitova paTrintellix kana Viibryd uye ukaona kuti une pamuviri, bata wako mupi wezvehutano nekukurumidza.
Inowanzo bvunzwa mibvunzo nezve Trintellix vs.Viibryd
Chii chinonzi Trintellix?
Trintellix ndeye SSRI, kana kusarudza serotonin reuptake inhibitor. Nekuda kweimwe chiitiko chayo pane serotonin receptors, inoiswawo seantypical antidepressant. Inowanikwa mune zita rezita fomu uye inoshandiswa kurapa kushushikana muvakuru.
Chii chinonzi Viibryd?
Viibryd izita-zita SSRI. SaTrintellix, inoiswawo seanodzvinyirira antipressant. Viibryd inoshandiswa kurapa kushushikana muvakuru.
Trintellix naViibryd zvakafanana here? / Ndeipi antidepressant yakafanana neViibryd?
Trintellix uye Viibryd vese vanoita seSSRI antidipressant mishonga yemishonga. Mimwe mishonga yeSRIRI yaungangonzwa nezvayo inosanganisira Celexa (citalopram), Lexapro (escitalopram), Luvox (fluvoxamine), Paxil (paroxetine), Prozac (fluoxetine), uye Zoloft (sertraline).
Zvisinei, kunyangwe Trintellix neViibryd vachiita seSSRIs, vanoshandawo mune dzimwe nzira pama serotonin receptors, ayo asinganyatsonzwisisika. Viibryd yakarongedzwa zviri pamutemo seSSRI uye 5-HT1A chikamu agonist. Trintellix inorondedzerwa seSSRI uye inoshanda seanopikisa, agonist, uye chikamu agonist yemazhinji serotonin receptors. Nekuda kwezvavakaita, ivo vanozivikanwa zvakare seatypical antidepressants. Zvimwe zveatypical antidepressants zvinosanganisira:
- Bupropion (Wellbutrin SR, Wellbutrin XL)
- Mirtazapine (Remeron)
- Trazodone
Imwe yakafanana (asi isina kufanana) antidipressant drug kirasi ndiyo SNRI kirasi, inomirira serotonin-norepinephrine reuptake inhibitors. Kirasi iyi inosanganisira zvinodhaka zvakaita seCymbalta (duloxetine), Effexor (venlafaxine), Pristiq (desvenlafaxine), uye Fetzima (levomilnacipran).
Trintellix kana Viibryd iri nani here?
Kunyange madhiragi ese ari maviri akabvumidzwa zvichienderana nezvidzidzo zvinodzorwa ne placebo, zvidzidzo hazvina kuenzanisa madhiragi maviri aya zvakananga. Imwe ongororo yakakura yezvidzidzo zvakawanda (ona pamusoro) yakawana Trintellix kuve pakati peanoshanda uye ari nani-anoregedza antidepressants. Nekudaro, iwo wakanakisa mushonga wako unogona chete kusarudzwa nachiremba wako, uyo anogona kutarisa pamufananidzo uzere wehutano hwako mamiriro uye nhoroondo uye mimwe mishonga yaunotora.
Ndinogona here kushandisa Trintellix kana Viibryd ndichiri nepamuviri?
Bvunza wako mupi wehutano yezano rekurapa. Ivo vanoyera zvakanakira kutora antidipressant maringe nenjodzi kumwana. Neonates akafumurwa kune mamwe antidepressants, anosanganisira SSRIs, mune yechitatu trimester yekuzvitakura, vakaita nhamo dzakakomba.
Kana iwe uchitova paTrintellix kana Viibryd uye ukaona kuti une nhumbu, bvunza OB-GYN yako nekukurumidza kuti uwane zano. Kana uri kuyamwisa , Bvunza OB-GYN yako zvakare.
Ndinogona here kushandisa Trintellix kana Viibryd nedoro?
Kwete. Trintellix kana Viibryd haifanire kutorwa nedoro nekuti mubatanidzwa unogona kuwedzera njodzi yekufema mweya (kunonoka kufema, kusawana oxygen yakakwana) uye kuwedzera kugadzikana uye kukotsira, uye kukanganisa kurinda. Iko kusanganisa kunogona zvakare kuwedzera kushungurudzika uye kushushikana.
Viibryd inobatsira kusagadzikana here?
Kunyangwe Viibryd isingatenderwe kurapa kunetseka, zvidzidzo zvakaratidza kuti zvinogona kubatsira kurapa zvakajairika kusagadzikana kusagadzikana. Naizvozvo, Viibryd dzimwe nguva inogona kupihwa kure-chitaridzi chekushushikana.
Viibryd ndeye bipolar here?
Viibryd haina kuratidzwa kurapa bipolar kusagadzikana. Iyo inongoratidzwa chete kuti ishandiswe mukuora mwoyo. Varwere vanofanirwa kuongororwa bipolar kusagadzikana vasati vatora Viibryd. Iyo kutsanangura ruzivo yeViibryd inotaura kuti kune varwere vane bipolar disorder, kushandisa Viibryd kana imwe antidepressant yekurapa iyo inoshungurudza episode inogona kukonzera yakavhenganiswa / manic episode.
Zvimwe Zvekushandisa:
