Carvedilol vs. metoprolol: Misiyano, kufanana, uye izvo zviri nani kwauri
Zvinodhaka Vs. ShamwariKuongorora kwemishonga & misiyano mikuru | Conditions kurapwa | Kubudirira | Inishuwarenzi kufukidza uye mutengo kuenzanisa | Zvimwe zvinokanganisa | Kubatana kwezvinodhaka | Yambiro | MIBVUNZO
Carvedilol uye metoprolol mishonga yemishonga inoshandiswa kurapa yakakwira BP (hypertension) uye matambudziko emoyo, sekushaya moyo. Iyi mishonga inogona zvakare kushandiswa kudzikisa njodzi yekufa mushure mekurwadziwa kwemoyo (myocardial infarction).
Ose ari maviri carvedilol uye metoprolol anosarudzwa se beta-blockers , inozivikanwawo se beta-adrenergic ichivharira vamiririri. Vanoshanda nekuvharira beta receptors, izvo zvinovharira mhedzisiro ye norepinephrine uye epinephrine mumoyo nemutsinga dzeropa. Beta-blockers anobatsira kudzikisa kukwira kweropa uye kunonoka kurova kwemoyo kudzikisira kunetseka pamoyo.
Carvedilol uye metoprolol ese ari maviri generic mishonga. Kunyangwe vachigovana zvakafanana, zvakare vane misiyano muyero, kuumbwa, uye mhedzisiro.
Ndeupi mutsauko mukuru pakati peCarvedilol neMetoprolol?
Carvedilol inoonekwa seisina-kusarudza beta-blocker. Izvi zvinoreva kuti carvedilol inogona kuvhara ese beta-1 receptors uye beta-2 receptors. Beta-1 zvinogamuchirwa zvinowanikwa mumoyo nepo beta-2 receptors inowanzo kuwanikwa mumhasuru dzakatsetseka. Carvedilol inodzivirirawo maalpha receptors mune tsinga, izvo zvinobatsira kudzikisa BP.
Carvedilol izita rakajairika reCoreg. Inowanzo kutorwa se 3.125 mg, 6.25 mg, 12.5 mg, kana 25 mg piritsi remuromo kaviri pazuva. Carvedilol inowanikwawo mune yakawedzera-kuburitsa fomu (Coreg CR) iyo inogona kutorwa kamwe zuva nezuva.
Metoprolol ndeye beta-1 inosarudza blocker iyo inowanzo vharidzira iyo beta-1 receptors mumoyo. Nekudaro, iyo zvakare inovhara beta-2 receptors, kunyangwe padiki padiki. Sarudzo beta-blockers inogona kuve nemhedzisiro dzakasiyana kana ichienzaniswa nevasina kusarudza beta-blockers.
Metoprolol inouya nenzira mbiri dzakasiyana dzemunyu: metoprolol tartrate uye metoprolol inotapira . Metoprolol tartrate, inozivikanwawo nezita rekuti Lopressor, ipiritsi rinoburitswa pakarepo rinouya musimba re25 mg, 37.5 mg, 50 mg, 75 mg, uye 100 mg. Metoprolol inotapira, inozivikanwawo nezita rekuti Toprol XL, yakawedzera-kuburitsa piritsi yemuromo inouya musimba re25 mg, 50 mg, 100 mg, uye 200 mg.
RELATED: Metoprolol vs. Atenolol
| Misiyano mikuru pakati pe carvedilol uye metoprolol | ||
|---|---|---|
| Carvedilol | Metoprolol | |
| Kirasi yemishonga | Beta-blocker | Beta-blocker |
| Brand / generic chinzvimbo | Brand uye generic vhezheni iripo | Brand uye generic vhezheni iripo |
| Chii chinonzi zita rechiratidzo? | Coreg (pakarepo-kuburitswa) Coreg CR (yakawedzera-kuburitswa) | Lopressor (pakarepo-kusunungurwa) Toprol XL (yakawedzera-kuburitswa) |
| Ndeapi mafomu (s) ayo mushonga unouya? | Hwendefa remuromo | Hwendefa remuromo |
| Ndeipi muyero wakajairwa? | Carvedilol (pakarepo-kuburitswa): 25 mg kaviri pazuva Carvedilol (yakawedzera-kuburitswa): 10 kusvika 80 mg kamwe pazuva Chipimo chemushonga chinoenderana nemamiriro ari kurapwa | Metoprolol tartrate (pakarepo-kuburitswa): 50 kusvika 100 mg kaviri pazuva Metoprolol succinate (yakawedzera-kuburitswa): 25 kusvika 100 mg kamwe pazuva Chipimo chemushonga chinoenderana nemamiriro ari kurapwa |
| Yakareba sei iyo yekurapa? | Nguva refu | Nguva refu |
| Ndiani anowanzoshandisa mushonga? | Vakuru | Vakuru |
Mamiriro ezvinhu anorapwa ne carvedilol uye metoprolol
Ose maviri carvedilol uye metoprolol succinate ndiwo FDA anotenderwa kurapa kutadza kwemoyo kunokonzerwa neischemia, hypertension, kana cardiomyopathy. Ose ari maviri beta-blockers anotenderwawo kubata chirwere cheBP.
Beta-blockers anowanzo shandiswa mukuwedzera kune mimwe mishonga senge angiotensin-inoshandura enzyme (ACE) inhibitors uye diuretics. Kuderedza systolic kana diastolic yeropa kunogona kubatsira kudzikisa njodzi yechiitiko chemoyo sekurwadziwa kwemoyo kana sitiroko.
Carvedilol uye metoprolol inogona kushandiswa kudzikisa njodzi yekurwara uye kufa kutevera chirwere chemwoyo . Iyi mishonga inogona zvakare kurapa kuruboshwe kwema ventricular kusagadzikana mushure mekurwadziwa kwemoyo.
Yese mishonga inogona kushandiswa kurapa angina pectoris, kana kurwadziwa kwepfupa, kunokonzerwa nechirwere chemoyo checoronary. Carvedilol kana metoprolol inogona kupihwa kuti ideredze angina kurwisa uye nekuvandudza kurovedza muviri kugona kune avo vane chirwere chemwoyo kana kukundikana kwemoyo.
Kunze-kwerevhizheni kushandiswa kwe carvedilol uye metoprolol kunosanganisira kurapwa kwe arrhythmias, kana isina kujairika moyo mutinhimira, senge atrial fibrillation.
| Mamiriro | Carvedilol | Metoprolol |
| Kutadza kwemoyo | Ehe | Ehe |
| Hypertension | Ehe | Ehe |
| Myocardial infarction | Ehe | Ehe |
| Angina pectoris | Kunze-chitaridzi | Ehe |
| Arrhythmia | Kunze-chitaridzi | Kunze-chitaridzi |
Carvedilol kana metoprolol inoshanda zvakanyanya here?
Iyo Carvedilol kana Metoprolol European Muedzo (COMET) yaive muyedzo unodzorwa wakasarudzika wakaenzanisa carvedilol uye metoprolol mune varwere vane chisingaperi moyo kutadza. Kutongwa kwakaitwa kweanoda kusvika makore mashanu muvarwere vanopfuura chiuru nemazana mashanu. Mhedzisiro, iyo yakaburitswa mu Lancet , yakaratidza zvese-zvinokonzeresa kufa kwe34% ye carvedilol maringe ne40% yemetoprolol. Mune mamwe mazwi, carvedilol yakawanikwa ichiwedzera kupona mumoyo yekutadza varwere kupfuura metoprolol.
Chidzidzo chekuenzanisa che2021 kubva ku American Zvinyorwa zveCardiology vakawana kuti pakanga pasina musiyano wakakosha muhuwandu hwekupona mushure mekurwadziwa kwemoyo ne carvedilol maringe ne metoprolol mune varwere vane reki yekusiya ventricular ejection chidimbu kupfuura 40%. Zvisinei, kune avo vane kuruboshwe ventricular ejection fraction pasi pe40%, carvedilol inogona kunge iri inoshanda beta-blocker.
Zvinoenderana ne meta-ongororo , carvedilol uye metoprolol zvakafanana mukushanda kana zvichishandiswa mushure mekurwadziwa kwemoyo. Kana ichienzaniswa ne placebo, ese beta-blockers akawanikwa achinyanya kudzora zviitiko zvemoyo uye zvinotevera kurwisa kwemoyo. Nekudaro, hapana chakakosha mabhenefiti pane ese-anokonzera kufa, revascularization, uye kuchipatara zvakawanikwa chero carvedilol kana metoprolol.
Ose ari maviri carvedilol uye metoprolol anogona kuva nzira dzinoshanda dzekurapa . Kurapa kunogona kuitirwa munhu zvichienderana nechengetwa mamiriro, zvinogona mhedzisiro, uye mutengo. Bvunza mupi wezvehutano nezvehutano hwakanakisisa iwe.
Kuvhavha uye mutengo kuenzanisa kwe carvedilol vs. metoprolol
Carvedilol yakafukidzwa nezvakawanda zveMedare uye zvirongwa zveinishuwarenzi. Iyo copay inoenderana nehurongwa hwekuumba uye kufukidza. Mari yepakati yemari ye carvedilol iri madhora zana nemakumi masere. Kunyangwe neinishuwarenzi, carvedilol inogona kudhura. Kushandisa kadhi reSingCare rekudzora re carvedilol rinogona kudzikisira mari yekubuda muhomwe kusvika pamadhora mashanu.
Metoprolol yakafukidzwawo neakawanda maMedare uye zvirongwa zveinishuwarenzi. Tsvaga wako wemishonga kana chirongwa cheinishuwarenzi kuti uone kuti iyo copay yemetoprolol yaizovei. Ivhareji yemari mutengo wemetoprolol iri kutenderera $ 168. Kadhi reSchoolCare rekudzikisa metoprolol tartrate kana metoprolol succinate inogona kukubatsira iwe kuchengetedza zvakanyanya pamutengo wekurapa.
| Carvedilol | Metoprolol | |
| Kazhinji yakafukidzwa neinishuwarenzi? | Ehe | Ehe |
| Inowanzo kufukidzwa neMedare Chikamu D? | Ehe | Ehe |
| Zvakawanda | Mahwendefa makumi matanhatu (6.25 mg) | Mahwendefa makumi matanhatu (25 mg) |
| Chaizvoizvo Medicare copay | $ 0– $ 15 | $ 0– $ 65 |
| SingleCare mutengo | $ 4 + | $ 4 + |
Zvakajairika mhedzisiro mhedzisiro ye carvedilol vs. metoprolol
Carvedilol uye metoprolol vanogovana mhedzisiro. Mhedzisiro inowanzoitika ye carvedilol dzungu, kuneta, kushaya simba, kushomeka kweropa (hypotension), manyoka, shuga yakakwira muropa (hyperglycemia), kunonoka kwemoyo (bradycardia), uye kuwedzera uremu. Iwo akajairika mhedzisiro mhedzisiro ye metoprolol kuneta, dzungu, manyoka, kurumwa, uye kushushikana.
Zvakakomba mhedzisiro mhedzisiro ye carvedilol uye metoprolol inogona kuitika, senge allergic reaction, zvine ngozi kudzikira kweropa, uye bronchospasms kana kupfupika kwekufema. Tsvaga kurapwa nekukasira kana iwe uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge uchinge waita,
| Carvedilol | Metoprolol | |||
| Side maitiro | Zvinoshanda? | Kakawanda | Zvinoshanda? | Kakawanda |
| Dzungu | Ehe | 32% | Ehe | 10% |
| Kuneta | Ehe | 24% | Ehe | 10% |
| Hypotension | Ehe | 9% | Ehe | 1% |
| Manyoka | Ehe | 12% | Ehe | 5% |
| Hyperglycemia | Ehe | 12% | Ehe | * |
| Kushaya simba | Ehe | 7% | Ehe | 10% |
| Inononoka kurova kwemoyo | Ehe | 9% | Ehe | 3% |
| Kurera huremu | Ehe | 10% | Ehe | * |
| Kufema kwekufema | Ehe | * | Ehe | 3% |
| Kutonhora kumagumo | Kwete | - | Ehe | 1% |
| Kushungurudzika | Ehe | <1% | Ehe | 5% |
| Itching | Ehe | <1% | Ehe | 5% |
* haina kutaurwa
Kakawanda hakubvi pane data kubva kumusoro-kuenda-kumusoro kutongwa. Izvi zvinogona kunge zvisiri runyorwa ruzere rwemhedzisiro mhedzisiro inogona kuitika. Ndokumbira utarise kuna chiremba wako kana mupi wezvehutano kuti udzidze zvimwe.
Kwayaka: DailyMed ( Carvedilol ), Zuva Nezuva ( Metoprolol )
Kusangana kwezvinodhaka zve carvedilol vs. metoprolol
Ose ari maviri carvedilol uye metoprolol anogona kudzikisa BP uye kunonoka kurova kwemoyo. Naizvozvo, ivo vanogona kudyidzana nemimwe mishonga ine zvakafanana mhedzisiro. Ose ari maviri carvedilol uye metoprolol, kufanana nevazhinji beta-blockers, anogona kuwirirana neropa rekudzikisa zvinomiririra, monoamine oxidase inhibitors (MAOIs), uye calcium chiteshi blockers. Kutora iyi mishonga pamwe chete kunogona kuwedzera njodzi yekumanikidza kweropa zvine ngozi kana kudzora kurova kwemoyo.
Carvedilol uye metoprolol zvinonyanya kugadziriswa muchiropa neCYP2D6 enzyme. Zvinodhaka zvinodzivisa iyi enzyme zvinogona kusangana ne carvedilol uye metoprolol, izvo zvinogona kutungamira kune akawedzera mazinga e carvedilol kana metoprolol. Kuwedzera kweropa re carvedilol kana metoprolol kunogona kukonzera njodzi yekuwedzera mhedzisiro.
Beta-blockers inogona kuwedzera ropa-shuga-kudzikisa mhedzisiro yemumuromo hypoglycemic mishonga senge glipizide, metformin, kana insulin. Kuchenjerera kunofanirwa kurairwa kana mishonga iyi ikatorwa pamwechete.
Ona tafura iri pazasi yekumwe kusangana kwezvinodhaka.
| Zvinodhaka | Kirasi yemishonga | Carvedilol | Metoprolol |
| Clonidine Guanethidine Reserpine | Alpha-adrenergic vamiririri | Ehe | Ehe |
| Selegiline Isocarboxazid Phenelzine | Monoamine oxidase inhibitors (MAOIs) | Ehe | Ehe |
| Amlodipine Nifedipine | Calcium chiteshi blockers | Ehe | Ehe |
| Fluvoxamine Fluoxetine Chlorpromazine Quinidine Ritonavir Terbinafine | CYP2D6 inhibitors | Ehe | Ehe |
| Glipizide Metformin Rosiglitazone Sitagliptin | Oral hypoglycemics | Ehe | Ehe |
| Dihydroergotamine Ergotamine | Ergot alkaloids | Ehe | Ehe |
| Hydralazine | Vasodilator | Ehe | Ehe |
| Digoxin | Cardiac glycosides | Ehe | Ehe |
| Cyclosporine | Immunosuppressants | Ehe | Ehe |
| Dipyridamole | Platelet inhibitors | Ehe | Ehe |
Bvunza nyanzvi yezvehutano kune kumwe kudyidzana kwezvinodhaka
Yambiro dze carvedilol uye metoprolol
Beta-blockers haifanire kumiswa nechimbichimbi. Panzvimbo iyoyo, ivo vanofanirwa kutapurwa zvishoma nezvishoma kudzikisa madosi. Panogona kuve nenjodzi yakawedzera yeakakunda coronary artery chirwere, angina, myocardial infarction, uye ventricular arrhythmias mushure mekumira nekukurumidza kusiya beta-blocker.
Beta-blockers anogona kuvhara zviratidzo zve hypoglycemia kana hyperthyroidism , senge kukurumidza kurova kwemoyo. Varwere vechirwere cheshuga uye avo vane matambudziko ehutachiona vangangoda kungwarira ne beta-blockers.
Ose carvedilol uye metoprolol anotakura yambiro dzebronchospasm, kunyanya kune avo vane chirwere chisingaperi chisingabvumirwe chemapapu (COPD) kana mamwe matambudziko ekufema. Zvisinei, zvidzidzo vakaratidza kuti beta-blockers inogona kudzikisira kuwedzera uye kuwedzera kupona kune avo vane COPD.
Udza wako mupi wezvehutano kana iwe uine nhoroondo ye congestive moyo kutadza, asthma, kunonoka kurova kwemoyo, matambudziko echiropa, kana kugadzikana kwehutano kune zvigadzirwa mu carvedilol kana metoprolol. Bvunza mupi wezvehutano nezve dzimwe yambiro uye zvidziviriro zvine chekuita nekushandiswa kwe carvedilol kana metoprolol.
Inowanzo bvunzwa mibvunzo nezve carvedilol vs. metoprolol
Chii chinonzi carvedilol?
Carvedilol ndeye beta-blocker mishonga iyo inoshandiswa kurapa kutadza kwemoyo uye neBP. Inogona zvakare kushandiswa kuwedzera kupona mushure mekurwadziwa kwemoyo. Carvedilol inouya mune ekukurumidza-kuburitsa uye akawedzera-mafomu mafomu. Yaiva FDA inogamuchirwa muna 1995.
Chii chinonzi metoprolol?
Metoprolol ndeye beta-blocker mishonga inogona kurapa kutadza kwemoyo, kuwedzerwa kwehutano, uye kusingaperi kurwadziwa kwepfupa. Metoprolol inotapira, iyo yakawedzeredzwa-kuburitswa fomu ye metoprolol zvakare FDA inogamuchirwa kurapa kutadza kwemoyo. Pakarepo-kuburitsa metoprolol ine metoprolol tartrate. Metoprolol pakutanga yaibvumidzwa FDA muna 1978.
Carvedilol uye metoprolol zvakafanana here?
Ose maviri carvedilol uye metoprolol ndeaya beta-adrenergic receptor blockers, kana beta-blockers. Ivo vaviri anoshandiswa kurapa chisingaperi moyo kutadza uye neBP. Nekudaro, izvo zvine akasiyana anoshanda zvinoshandiswa uye zvinoshanda munzira dzakasiyana zvishoma. Carvedilol isiri-yekusarudza beta-blocker uye metoprolol ndeye beta-1 inosarudza beta-blocker.
Carvedilol kana metoprolol iri nani here?
Carvedilol uye metoprolol mese mishonga inoshanda zvakanyanya kana ichienzaniswa ne placebo. Carvedilol inogona kunge iri nani kune vamwe varwere vane kusakwana kwemoyo, sekureva kwe COMET kuyedza . Carvedilol uye metoprolol zvakafanana zvinobudirira pakuwedzera kupona mushure mekurwadziwa kwemoyo. Mirayiridzo kubva kuAmerican College of Cardiology (ACC) uye American Heart Association (AHA) inokurudzira kushandiswa kweiyo carvedilol, metoprolol succinate, kana bisoprolol yevarwere vane kutadza kwemoyo nechikamu chiduku cheejection. Bvunza mupi wezvehutano nezve yakanakisa yekurapa sarudzo yeako chaiwo mamiriro.
Ndinogona here kushandisa carvedilol kana metoprolol ndichiri nepamuviri?
Beta-blockers ari inowanzoshandiswa mune vakadzi vane nhumbu vane moyo mamiriro. Nekudaro, hapana humbowo hunoratidza kuti beta-blockers akachengeteka zvachose kana kukuvadza panguva yekuzvitakura. Ose ari maviri carvedilol uye metoprolol anogona kutakura njodzi yekukuvara kwemucheche. Bvunza mupi wezvehutano nezvezvehutano usati washandisa beta-blocker panguva yekuzvitakura.
Ndinogona here kushandisa carvedilol kana metoprolol nedoro?
Panogona kuve nekuwedzera njodzi yemhedzisiro kana uchibatanidza beta-blocker nedoro. Kutora carvedilol kana metoprolol nedoro kunogona kuwedzera njodzi yekutsimwaira, dzungu, uye yakaderera BP. Doro rinogona zvakare kudzikisira kushanda kwe beta-blockers.
Ko carvedilol inoderedza BP kupfuura metoprolol here?
Carvedilol inogona kudzikisa kuwedzera kweropa kupfuura metoprolol. Izvi zvinodaro nekuti carvedilol ine vasodilating zvimiro zvinobatsira kuzorodza tsinga dzeropa uye kudzikisa BP. Hapana zvidzidzo zvakafananidza zvakananga kuderedzwa kweropa kudzikisa mhedzisiro ye carvedilol uye metoprolol. Zvisinei, carvedilol inogona kubatsira kudzivirira zviitiko zvemoyo kudarika metoprolol muvarwere vane chirwere cheBP.
Unogona here kuchinja kubva metoprolol kuenda ku carvedilol? / Zvakachengeteka here kuchinja beta blockers?
Zvinowanzo chengeteka kushandura beta-blockers kana zvichidikanwa kana sekurudzirwa nemupi mupi wezvehutano. Zvichienderana ne beta-blocker, switch inogona kukurumidza kana kuti iyo yekutanga beta-blocker inogona kurumurwa nepo muyero weiyo nyowani beta-blocker uchiwedzera zvishoma nezvishoma kuenda kune chakanangwa dosi. Kushanya kwekutevera kunogona kudikanwa kuti uongorore kushanda kweiyo beta-blocker nyowani.
Chii chakanaka chinotsiva carvedilol?
Iyo yakanakisa kutsiva carvedilol kunoenderana nemamiriro ari kurapwa. Kune mishonga miviri chete FDA-inogamuchirwa yekurapa kutadza kwemoyo kunze kwe carvedilol: bisoprolol uye metoprolol succinate. Mimwe mienzaniso ye beta-blockers inosanganisira atenolol, nebivolol, uye propranolol.
Iko kune zvirinani beta blocker kupfuura metoprolol?
Dzimwe nzira dzinogona kuitika kune metoprolol inotapira yekurapa kusakundikana kwemoyo inosanganisira bisoprolol uye carvedilol. Iyo iri nani beta blocker ndiyo ichave inoshanda zvakanyanya kwauri. Zvimwe zvinhu zvinogona kutora chinzvimbo mukusarudza beta blocker, senge mutengo, mhedzisiro, uye mimwe mishonga yaunogona kutora.
