Metoprolol vs. atenolol: Misiyano, kufanana, uye izvo zviri nani kwauri
Zvinodhaka Vs. ShamwariKuongorora kwemishonga & misiyano mikuru | Conditions kurapwa | Kubudirira | Inishuwarenzi kufukidza uye mutengo kuenzanisa | Zvimwe zvinokanganisa | Kubatana kwezvinodhaka | Yambiro | MIBVUNZO
Metoprolol uye atenolol zvinoshandiswa pakurapa mhando dzakasiyana dzemamiriro ane hukama nemoyo kusanganisira angina pectoris uye neBP, kana kukwirira kweropa. Angina pectoris inoreva mamiriro ekuti iwe unonzwa kurwadziwa pachipfuva kana kusagadzikana izvo zvinokonzeresa kuti moyo wako usatambira yakakwana oxygen-yakazara ropa. Izvi zvinogona kuve zvinowanzoitika panguva dzekunetseka kwakanyanya kana kushanda nesimba. Hypertension zvinoreva kuva neBP yakakwira uko ropa rinoyerera kuburikidza netsinga dzako riri pakakwirira pane zvakajairika.
Metoprolol uye atenolol vari mukirasi imwechete yezvinodhaka uye vanorapa mamiriro akafanana, asi kune mamwewo misiyano pakati pemishonga iyi, uye isu tichakurukura izvo zviri pano.
Ndeupi mutsauko mukuru pakati metoprolol uye atenolol?
Metoprolol imushonga-chete mushonga unorondedzerwa se cardioselective beta-1-inosarudza adrenergic agonist, neimwe nzira inonzi beta blockers. Beta 1 zvinogamuchirwa zvine chekuita nekusimudzira kwemoyo zvichikonzera kuwedzera kwemoyo uye kukwikwidza kwakasimba kwemhasuru yemoyo. Kuvhara izvi zvinogamuchirwa, sezvinoita metoprolol, zvinoguma nekunonoka kwemoyo uye kusasimba kwakasimba. Metoprolol is cardioselective zvichireva kuti zvinowanzoitika zvinokanganisa beta 1 receptors mumoyo, uye kashoma kuti ikanganise mamwe marudzi e beta receptors ari mukati memuviri wese, senge mumafafitera ako.
Metoprolol inowanikwa mumahwendefa ekukurumidza-kuburitsa mu25 mg, 37.5 mg, 50 mg, 75 mg, uye 100 mg mapiritsi. Iyo yekukurumidza-kuburitswa inozivikanwa zvakare nechisimba se metoprolol tartrate. Iyo yakawedzerwa-kuburitsa fomu yemetoprolol, inozivikanwa se metoprolol succinate, inowanikwa musimba re25 mg, 50 mg, 100 mg, uye 200mg. Iwo akawedzeredzwa-kuburitswa macapsule anowanikwa musimba rakafanana sepiritsi. Iko kune zvakare 1 mg / ml jekiseni remhinduro pamwe nehupfu hwemuromo. Hafu yeupenyu metoprolol tartrate ingangoita maawa matatu, uye hafu yeupenyu metoprolol inotapira ingangoita maawa manomwe. Izvi zvinoreva kuti akawedzeredzwa-ekuburitsa fomati haafanire kubviswa kazhinji.
Atenolol iriwo mushonga unonyorwa unosarudzika se cardioselective beta-1-inosarudza adrenergic agonist. Inoshanda nenzira imwecheteyo se metoprolol mumuviri. Hafu yeupenyu yeatenolol ingangoita maawa matanhatu kusvika manomwe, uye nekudaro inogona kugara kwenguva yakareba kupfuura mamwe metoprolol doses. Atenolol inowanikwa mu25 mg, 50 mg, uye 100 mg mapiritsi.
| Misiyano mikuru pakati pemetoprolol uye atenolol | ||
|---|---|---|
| Metoprolol | Atenolol | |
| Kirasi yemishonga | Cardioselective beta-1-inosarudza adrenergic agonist (beta blocker) | Cardioselective beta-1-inosarudza adrenergic agonist (beta blocker) |
| Brand / generic chinzvimbo | Brand uye generic inowanikwa | Brand uye generic inowanikwa |
| Chii chinonzi zita rechiratidzo? | Lopressor, Toprol XL | Tenormin |
| Ndeapi mafomu (s) ayo mushonga unouya? | Pakarepo uye yakawedzerwa-kuburitsa mapiritsi emuromo uye macapuleti, jekiseni remhinduro, poda yemuromo | Pakarepo-kusunungura mapiritsi emuromo |
| Ndeipi muyero wakajairwa? | 50 mg kaviri pazuva | 50 mg kamwe pazuva |
| Yakareba sei iyo yekurapa? | Nguva refu | Nguva refu |
| Ndiani anowanzoshandisa mushonga? | Vana nevakuru | Vana nevakuru |
Mamiriro ezvinhu anorapwa ne metoprolol uye atenolol
Metoprolol uye atenolol zvese zvinoshandiswa pakurapa angina pectoris uye neBP. Inogona kushandiswa mune isingagumi, yakagadzikana angina kana isina kugadzikana angina. Chisingaperi, chakasimba angina chinoitika fungidzira kana iwe uchizvishandisa nesimba panyama kana uri pasi pehuwandu hwakawanda hwekushushikana. Angina isina kugadzikana haina fungidziro uye inogona kuitika kunyangwe pakuzorora.
Kana ikashandiswa pakurapa kwehypertension, metoprolol uye atenolol inogona kushandiswa yoga kana musanganiswa nemimwe mishonga inodzvinyirira mweya. Kana madhiragi aya achishandiswa muchirongwa chekurapa kweanoshanda, anofungidzirwa, kana akasimbiswa myocardial infarction, kana chirwere chemwoyo, iwo ari chikamu cheiyo yakawanda-mishonga regimen iyo inogona zvakare kusanganisira angiotensin-inoshandura enzyme inhibitors (ACE inhibitors) uye diuretics. Mune ischemic myocardial chirwere, beta blockers inoderedza okisijeni kudiwa kwemyocardial mhasuru uye vane antiarrhythmic zvivakwa.
Metoprolol uye atenolol zvakare imwe neimwe inoshandiswa kure-chitaridzi kune zvimwe zvinoratidza. Kunze-chitambi kushandiswa kunoreva kushandiswa kwechiratidzo chisina kubvumidzwa neKudya neDrug Administration (FDA). Ivo anowanzo shandiswa kubatsira kudzivirira migraines uye kudzora kudedera.
Izvi zvinogona kunge zvisiri runyorwa rwakakwana rweanogona kushandiswa emishonga iyi. Chiremba wako chete kana nyanzvi yehutano inogona kusarudza kana imwe yemishonga iyi inokodzera mamiriro ako.
| Mamiriro | Metoprolol | Atenolol |
| Angina pectoris (inosanganisira isingagumi, angina akatsiga, uye isina kugadzikana angina) | Ehe | Ehe |
| Hypertension | Ehe | Ehe |
| Kutadza kwemoyo | Ehe | Kwete |
| Myocardial infarction | Ehe | Ehe |
| Yekushomeka kwemoyo kudzora muatrial fibrillation kana atrial flutter | Kunze-chitaridzi | Kunze-chitaridzi |
| Kudedera | Kunze-chitaridzi | Kunze-chitaridzi |
| Migraine prophylaxis | Kunze-chitaridzi | Kunze-chitaridzi |
| Paroxysmal supraventricular tachycardia prophylaxis | Kwete | Kunze-chitaridzi |
| Kunwa doro | Kwete | Kunze-chitaridzi |
Ko metoprolol kana atenolol inoshanda zvakanyanya here?
Metoprolol uye atenolol zvakadzidzwa uye zvikaenzaniswa zvakanyanya kune zvakasiyana zvinoratidza uye mhedzisiro. A meta-ongororo rakaburitswa muna2017 rakaongorora kushanda kwekuenzanisa kweaya maviri beta blockers pamwe nepropranolol uye oxprenolol nekutarisa mhedzisiro yemakiriniki ekuedzwa. Metoprolol yakaratidza kudzikisira kwakanyanya munjodzi yekufa kwemoyo kana ichienzaniswa neatenolol. Metoprolol zvakare yakaratidza kuderera kwemaitiro ezvose-kukonzera kufa uye coronary moyo chirwere. Kana ichiongororwa kudzikira kwenjodzi yekurohwa, metoprolol yakaratidza kunge iri nani pane atenolol futi. Pane data izvo zvinoratidza kuti ese madhiragi anoshanda achipesana ne placebo uye hapana musiyano wakakura pakati peatenolol uye metoprolol maererano nekwaniso yavo yekudzora BP (hypertension).
Metoprolol yakaratidzirwa kudzikisa ese systolic uye diastolic reropa. Atenolol inogona kukanganisa systolic BP kupfuura diastolic, kunyanya munguva dzekuedza.
Zvichienderana neruzivo urwu, chiremba wako anogona kusarudza kutanga ne metoprolol kutanga paunenge uchisarudza mumiririri wako. Chiremba wako chete ndiye anogona kuona kana beta blocker kurapwa kwakakukodzera.
Kuvhara uye mutengo kuenzanisa kwemetoprolol vs. atenolol
Metoprolol imishonga yemishonga inovharwa nezvose zviri zviviri zvekutengeserana uye zveMishuwarenzi zvirongwa. Kana iwe uchibhadhara mari yemetoprolol tsamba, unogona kubhadhara madhora makumi matatu nerimwe pamwedzi mumwe chete. SingleCare inopa coupon iyo inogona kukubvumidza iwe kuti ubhadhare madhora mana emadhora metoprolol.
Atenolol imishonga yemishonga inovharwa nezvose zvekutengeserana uye zveMishuwarenzi zvirongwa. Pasina inishuwarenzi, unogona kubhadhara madhora makumi matatu pamutengo wemazuva makumi matatu wemapiritsi makumi mashanu. Nekadhi rekuchengetedza kubva kuSingleCare, unogona kubhadhara mari ingangoita madhora gumi nemana pachirongwa ichi.
| Metoprolol | Atenolol | |
| Kazhinji yakafukidzwa neinishuwarenzi? | Ehe | Ehe |
| Inowanzo kufukidzwa neMedare Chikamu D? | Ehe | Ehe |
| Zvakawanda | 60, 50 mg mahwendefa | 30, 50 mg mahwendefa |
| Chaizvoizvo Medicare copay | $ 0- $ 9 | $ 0- $ 10 |
| SingleCare mutengo | $ 4- $ 22 | $ 9- $ 25 |
Zvakajairika mhedzisiro mhedzisiro yemetoprolol vs. atenolol
Cardioselective beta blockers senge metoprolol uye atenolol inononoka mwero unorova moyo pamwe nesimba rairova. Uku kunonoka kweiyo yemoyo kurovera kunogona kutungamira kune bradycardia, kana yakadzika moyo rate. Kana moyo usiri kurova zvine simba, dzimwe nguva kuyerera kweropa hakusvike kumagumo nekumanikidza kwatingave tichida, zvichitungamira kumagumo angangove anotonhora kune anobata.
Kuderera kusingamanikidze kuyerera kweropa uye kuderera kweanomanikidza kumanikidza kunogona zvakare kutungamira kumhedzisiro senge postural hypotension, musoro wakareruka uye kunzwa dzungu pakumira mushure mekugara kana kurara pasi. Musoro unogona kuitikawo kuvarwere vanotora metoprolol uye atenolol.
Izvi hazviitirwe kuve izere rondedzero yemhedzisiro. Ndokumbirawo ubvunze wemishonga wako kana chiremba kuti uwane yakazara runyorwa.
| Metoprolol | Atenolol | |||
| Side maitiro | Zvinoshanda? | Kakawanda | Zvinoshanda? | Kakawanda |
| Kuneta | Ehe | Hazvina kutaurwa | Ehe | 0.6% |
| Dzungu | Ehe | Hazvina kutaurwa | Ehe | 4% |
| Kushungurudzika | Ehe | Hazvina kutaurwa | Ehe | 0.6% |
| Kutemwa nemusoro | Ehe | Hazvina kutaurwa | Kwete | n / a |
| Kufema kwekufema | Ehe | Hazvina kutaurwa | Ehe | 0.6% |
| Bradycardia | Ehe | Hazvina kutaurwa | Ehe | 3% |
| Kutonhora kumagumo | Ehe | Hazvina kutaurwa | Kwete | n / a |
| Hypotension | Ehe | Hazvina kutaurwa | Ehe | piri% |
| Kushungurudza | Ehe | Hazvina kutaurwa | Kwete | n / a |
| Manyoka | Ehe | Hazvina kutaurwa | Ehe | piri% |
| Nausea | Ehe | Hazvina kutaurwa | Ehe | 4% |
| Mapundu | Ehe | Hazvina kutaurwa | Kwete | n / a |
Kunobva: Metoprolol ( Zuva Nezuva Atenolol ( Zuva Nezuva )
Kubatana kwezvinodhaka kwemetoprolol vs. atenolol
Digoxin uye beta blockers senge metoprolol uye atenolol imwe neimwe inokanganisa kumanikidza kwekutsemuka uye kurova kwemoyo. Kana zvapihwa pamwechete, varwere vari panjodzi yekuwedzera bradycardia uye hypotension. Kurova kwemoyo, kuwedzerwa kweropa, uye zvimwe zviratidzo zvekushaya simba kwemoyo zvinofanirwa kuongororwa nguva nenguva kana zvichifanirwa kupihwa pamwechete.
Metoprolol uye Atenolol inosanganiswa necalcium chiteshi blockers senge amlodipine inogona kukonzera kuwedzera kwekuwedzera kwecontact contractility izvo zvinogona kuve nenjodzi. Kana iko kusanganisa kuchidikanwa, zvakakosha kuti uwane zviyero zvebasa rekutanga uye nekuteedzana kunoenderana.
Kazhinji antidepressants senge fluvoxamine, clomipramine, uye sarotonin reuptake inhibitors (SSRIs) inosarudzika inhibit enzyme (CYP2D6) iyo inokonzeresa metabolism yemetoprolol. Kana ikapihwa pamwe chete ne metoprolol, iyi mishonga inogona kutungamira mukuwedzera kwemetoprolol ropa mazinga. Izvi zvinogona kutungamira mukuwedzera mhedzisiro ne metoprolol pane yemoyo system.
Izvi hazvirevi kuti zvive zvese-zvinosanganisira runyorwa rweanogona kusangana madhiragi. Iwe unofanirwa kubvunza yako yehutano nyanzvi kune yakazara runyorwa.
| Zvinodhaka | Kirasi yemishonga | Metoprolol | Atenolol |
| Reserpine Clonidine Methyldopa | Alfa adrenergic vanopikisa | Ehe | Ehe |
| Selegiline Phenelzine Isocarboxazid | Monoamine oxidase inhibitors (MAOIs) | Ehe | Ehe |
| Digoxin | Dhijitari glycosides / antiarrhythmic | Ehe | Ehe |
| Amlodipine Nifedipine Diltiazem Verapamil | Calcium chiteshi blockers | Ehe | Ehe |
| Fluvoxamine Clomipramine Desipramine | Zvinodzvinyirira | Ehe | Kwete |
| Fluoxetine Paroxetine Sertraline | Kusarudza serotonin reuptake inhibitors (SSRIs) | Ehe | Kwete |
| Hydralazine | Vasodilator | Ehe | Ehe |
| Dipyridamole | Platelet inhibitor | Ehe | Ehe |
| Ergotamine Dihydroergotamine | Ergot alkaloids | Ehe | Ehe |
Yambiro dze metoprolol uye atenolol
Beta blockers inokonzeresa kuora mwoyo kwecontactility. Mune vamwe varwere vane zvimwe zvinenjodzi, izvi zvinogona kukonzera kutadza kwemoyo. Kana izvi zvikaitika, kutadza kwemoyo kunofanirwa kurapwa zvinoenderana nazvino nhungamiro.
Beta blockers haifanire kumiswa kamwe kamwe, kunyanya kune varwere vane coronary artery chirwere. Kurwiswa kwemoyo uye ventricular arrhythmias zvakataurwa kune varwere vanongoerekana varega beta blockers.
Kana zvichikwanisika, beta inodzivirira vamiririri inofanirwa kudzivirirwa kune varwere vane bronchospastic zvirwere, senge asthma. Kushandiswa pamwe chete kunogona kuwedzera chirwere chebronchial. Kana zvichidikanwa kushandisa beta blockers, cardioselective iwo anosarudzwa. Iko kushandiswa kweasina-cardioselective beta blockers, senge carvedilol, haina kukurudzirwa.
Atenolol dosing inofanirwa kudzikiswa muvarwere vane chirwere chetsvo kana kukanganiswa kweitsvo sezvo kubuda kwemushonga kunonoka.
Yakasarudzika inodzorwa kliniki kuyedzwa rakaburitswa neThe Lancet inoratidza kuti varwere vakavhiyiwa vari pa beta blockers (metoprolol chaiyo) vari panjodzi yakawedzera yemhedzisiro yakakomba sekurwadziwa kwemoyo kana sitiroko. Nekudaro, hazvikurudzirwe kumisa iyo beta-blocker yekuvhiya kana murwere akagadzikana pairi.
Izvo zvakakosha kuti uzive kuti zvingave zvakaoma kucherechedza zviratidzo zve hypoglycemia mune vane chirwere cheshuga, senge tachycardia, nekuti ichave yakavharirwa nemhedzisiro ye beta blocker.
Dzungu uye hypotension inokonzerwa ne metoprolol uye atenolol zvinogona kuwedzera njodzi uye chiitiko chekuwa, izvo zvinogona kuve nenjodzi kana kutungamira mukukuvara kwemusoro. Kuchenjerera kunofanirwa kutorwa kune vakuru vakuru avo vatove nenjodzi yekudonha.
Chiremba wako chete ndiye anogona kusarudza kana metoprolol kana atenolol therapy yakachengeteka kwauri.
Inowanzo bvunzwa mibvunzo nezve metoprolol vs. atenolol
Chii chinonzi metoprolol?
Metoprolol imishonga inonyorwa inorondedzerwa se cardioselective beta blocker. Inoshanda kurapa kuwedzera kwehosha uye angina nekuderedza kurova kwemoyo uye kumanikidza kwekutsemuka kwemoyo. Inowanikwa mune yekukurumidza-kuburitsa mapiritsi emuromo, akawedzera-kuburitsa mapiritsi uye makapisi, jekiseni mhinduro, uye mukanwa upfu.
Chii chinonzi atenolol?
Atenolol ndeye cardioselective beta blocker iyo inowanikwa nemushonga chete. Inoshanda kurapa kuwedzera kwehosha uye angina nekuderedza kurova kwemoyo uye kumanikidza kwekutsemuka kwemoyo. Inowanikwa mune yekukurumidza-kusunungura mapiritsi emuromo.
Metoprolol uye atenolol zvakafanana here?
Metoprolol uye atenolol ndiwo ega cardioselective beta blockers, uye pharmacology yemabatiro avanoita akafanana, asi iwo haana kufanana chaizvo. Metoprolol ine mafomu maviri anowanikwa, imwe pfupi-inoshanda uye imwe yekuita kwenguva refu, uye inogona kuderedzwa kamwe chete kana kaviri zuva nezuva zvichienderana nekuumbwa. Metoprolol zvakare lipophilic, zvichireva kuti inowanzo nyungudika mune yakawanda mafuta (lipid) nharaunda. Neichi chikonzero, kutora Metoprolol nechikafu kunowanzo kurudzirwa. Atenolol inodhonzwa kamwe chete zuva nezuva uye iri hydrophilic. Atenolol inonyungudika munzvimbo dzine mvura, uye nekudaro inongoda kutorwa negirazi remvura.
Iko metoprolol kana atenolol zvirinani?
Dhata inoratidza kuti izvi zviviri zvinodhaka zvine mhedzisiro yakafanana muvarwere vane hutachiona hwehosha, kunyangwe hazvo kwenguva yakareba mhedzisiro yechirwere chemoyo, sekuderera kwehurwere, inogona kuve inonakidza ne metoprolol.
Ndinogona here kushandisa metoprolol kana atenolol ndichiri nepamuviri?
Metoprolol iri muPamuviri Chikamu C.Hakuna zvakanyatso chengetedzwa zvidzidzo zvekumisikidza kuchengetedzeka pakubata. Bvunza chiremba nezvekutora Metoprolol uchiri nepamuviri kana kuyamwa. Atenolol iri muPamuviri Chikamu D. Iyo inopesana uye haifanire kutorwa panguva yekuzvitakura. Bvunza chiremba nezve nhanho dzekutora uchironga nhumbu kana kuyamwisa.
Ndinogona here kushandisa metoprolol yeatenolol nedoro?
Kunyange paine pasina kujeka kudyidzana kwemakemikari pakati pedoro uye beta blockers senge metoprolol uye atenolol, kunwa doro kunokonzeresa kuti BP yako iwire. Mubatanidzwa wemishonga nedoro zvinogona kukuisa panjodzi yekufenda kana kudonha nekukuvara.
