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Metformin inokonzeresa kuora mwoyo?

Zvinodhaka Info

Metformin mushonga wakakurumbira wemishonga inoshandiswa kurapa Type II chirwere cheshuga. Mhedzisiro yemetformin, mushonga weguanuide, kudzikisa huwandu hweshuga muropa remunhu. Kubvira metformin yarova pamusika, pakave nenhema zhinji nezve kubatana kwayo kune dhementia, chirwere chinosangana nekuvhiringidzika, kurasikirwa mundangariro, uye manzwiro anochinja. Muchikamu chino, tichaenda tichinyatso tarisa kubatana pakati metformin uye dementia. Pane kubatana here? Kana zvirizvo, ndezvipi?

Chii chinonzi dementia?

Kutanga, ngatitarisei zvakanyanya kuti chii chinonzi dementia. Dementia izwi rinoshandiswa kutsanangura zvirwere nezvirwere zvinokonzeresa matambudziko sekurasikirwa nendangariro nenyaya dzekutaura nekufunga. Imwe mhando ye dementia ndeye Alzheimer's, iyo inowanzo bata vakuru vakuru. Chirwere cheAlzheimer chirwere cheeurodegenerative ndicho chinonyanya kukonzeresa kuora mwoyo, kuchiteverwa padyo nedambudziko revascular dementia. Chirwere cheAlzheimer chinoshanda nekudzikisira maseru etsinga muuropi. Kufanana neAlzheimer's, chirwere chePasinson ndechimwe chinozivikanwa mamiriro anogona kukonzeresa chiitiko chekuora mwoyo.

Unoda akanakisa mutengo pane metformin?

Saina kuti metformin mitengo yambiro uye uwane kana mutengo uchinja!

Wana machenjedzo emitengo

Metformin yakabatana nedementia here?

Mhinduro yakapusa ndeyekuti metformin haikonzere kuora mwoyo uye inogona kubatsira kudzikisira njodzi yemunhu, 'anodaro Verna R. Porter, MD , chiremba wezveuropi uye director weDementia uye Alzheimer's Zvirwere Zvirongwa kuProvidence Saint John's Health Center muSanta Monica, California. Muchokwadi, a kudzidza kuchangobva kuitika ye17,000 veterans vane chirwere cheshuga vakaona kuti kutora metformin kwaive kwakanangana nenjodzi yakaderera yeshungu kupfuura mamwe madhiragi eshuga anozivikanwa sa sulfonylureas (sa glyburide uye glipizide), Dr. Porter anodaro.

Chimwe chidzidzo Zvakare zvakaratidza kuti kugona kwekuziva kwemamwe marudzi emadzinza kunogona kubatsirwa ne metformin. Yakaratidza kuti metformin kushandiswa kwaibatanidzwa nemitengo yakadzikiswa ye dementia uye nekuvandudza kugona kwehukama pakati pevarwere vemuAmerican American vane Type 2 chirwere cheshuga (hazard ratio [HR] = 0.73; 95% nguva yekuvimba [CI], 0.6-0.89) asi kwete varwere vachena ( HR = 0.96; 95% CI, 0.9-1.03).

Izvo zvakati, zvimwe zvidzidzo ratidza kubatana kwakasiyana pakati pevarwere vechirwere cheshuga 'kushandiswa kwenguva refu kwemetformin uye mamwe ma insulin sensitizers uye chiitiko chedementia. Vamwe cohort zvidzidzo ratidza hunowedzera njodzi yekuva nedementia kana uchishandisa metformin.

Mune mamwe mazwi, iko kutsvagisa kwazvino mukubatanidza pakati pekushandisa metformin, kunyanya semonotherapy, uye chirwere chedementia kuongororwa, kwakasanganiswa uye hakusati kwajeka. Mimwe miedzo yekiriniki uye zvidzidzo zvekucherechedza zvinodiwa.

RELATED: Chirwere cheshuga uye kurapwa

Metformin inogona kukonzera ndangariro matambudziko here?

Tsvagurudzo haina kujeka panguva ino kana metformin inogona kukonzera ndangariro matambudziko, saka hapana mhinduro yakajeka. Zvisinei, vanachiremba vakawanda vachiri kukurudzira metformin sechirwere chekutanga chekurapa kwechirwere cheshuga chechipiri.

Chii chingave chiri kukonzera matambudziko ekurangarira kune avo vari kutora metformin haisi iyo mishonga pachayo, asi hosha iri pasi: chirwere cheshuga. Hutano hwepfungwa mhedzisiro yechirwere cheshuga inogona kutangira pane hushoma hwekuziva kwekuremara kusvika kune hwakanyanya. Muchokwadi, a 2011 kiriniki yekudzidza yakaratidza njodzi iri pakati peType 2 chirwere cheshuga mellitus uye dementia, ichitaura iyo mhando 2 chirwere cheshugainowedzera njodzi yeundangariro kupfuura zvakapetwa kaviri.

Imwe kudzidza kubva ku2017 yakaita kubatana pakati peiyo insulin kudzivisa-hunhu hwechirwere cheshuga-uye-kwenguva refu yekuziva kuderera.

Chinokosha ndechekuti kumwe kutsvagurudza kunodiwa kuti uwane mhinduro dzakajeka dzekuti metformin inobatsira sei kumatambudziko ekurangarira, zvisinei, iyo mamiriro ezvinhu ekuti metformin inobata-rudzi rwechipiri chirwere cheshuga-inogona kutungamira kudzikira kwekuziva kwekuita uye ndangariro nyaya.

Ndeipi mhedzisiro mhedzisiro yekushandisa kwenguva yakareba metformin?

Kazhinji kana vanhu vakarairwa metformin yechirwere cheshuga, ivo vari mairi kwekutora kwenguva refu, saka kune mhedzisiro yenguva refu yekufunga.

Aya ndiwo akanyanya kukanganisika mhedzisiro yemetformin:

Gasi
Dumbu kurwadziwa
Kushungurudzika / kurutsa
Manyoka
Kushungurudza
Kuonda
Kutemwa nemusoro
Izvo zvisingafadzi esimbi kuravira mumuromo

Kazhinji izvi zvinowanzoitika mhedzisiro zvinopera mukati memazuva mashoma kana vhiki, kunyanya kana zvinyoro. Dzimwe nguva kune njodzi yakadzikira yeaya manyoro mhedzisiro kana uchitora metformin nekudya. Nekudaro, zvakakomba mhedzisiro mhedzisiro ingangoda zano rekurapa nekukurumidza kubva kune wehutano mutapi. Ivo vanokuraira iwe pane yakanakisa nzira yekuita uye uteedzere zvinoenderana.

Pazasi pane runyorwa rweakakomba mhedzisiro mhedzisiro yemetformin inoda kurapwa nekukurumidza.

Lactic acidosis

Ichi chinotyisidzira hupenyu chinoitika kana paine njodzi yekuvaka-lactic acid, pamwe nekuderera kwepH uye kusagadzikana kwemagetsi mumuviri. Zvinoitika kana itsvo dzisiri kushanda nemazvo, uye nekudaro hadzisi kunyatsoburitsa metformin. Yenguva refu chirwere cheshuga chinogona kutungamira kumatambudziko eitsvo, zvichikonzera kuvaka-metmetin mumuviri, iyo inogadzira lactic acidosis. Iko mukana wekuvandudza lactic acidosis inowedzera mune varwere vane chirwere chemwoyo kana congestive moyo kutadza.

Zviratidzo zveactic acidosis yekutarisa zvinosanganisira:

Kuneta
Kushaya simba
Kusanzwisisika kwemhasuru kurwadziwa
Kunetseka kufema
Kurara zvisina kujairika
Dumbu kurwadziwa, kuda kurutsa, kana kurutsa
Dzungu kana hurema
Inononoka kana isina kujairika kurova kwemoyo

Hypoglycemia (yakaderera ropa shuga)

Pachega, metformin haizokonzere hypoglycemia. Nekudaro, muzviitiko zvisingawanzoitika shuga yakadzika muropa inogona kuitika kana ikabatanidzwa nechikafu chisina kudya, kurovedza muviri, kunwa doro rakawandisa, kana zvimwe zvinodhaka zvinorwisa chirwere cheshuga. Kuruboshwe kusarapwa, hypoglycemia inogona kukonzera kuti vamwe vanhu vapfuure, vabatwe, uye muzviitiko zvakaipisisa, zvinotungamira mukukuvara kwehuropi zvachose.

Izvi zvinotevera zviratidzo zvehuwandu hweropa glucose mazinga:

Kushaya simba
Kuneta
Nausea
Kusvipa
Dumbu kurwadziwa
Dzungu
Musoro wakareruka
Asina kujairika nekukurumidza kana kunonoka kurova kwemoyo

Anemia

Anemia kuverenga kwakaderera kwemasero matsvuku eropa, ayo anogona kukonzerwa nemazinga akaderera evitamini B12. Sezvo metformin inogona kukonzera kushomeka kwevhitamini B12, zvakakosha kuti varwere vatore chero vhitamini B12 yekuwedzera kana kuona kuti vari kumedza zvakakwana kuburikidza nechikafu chavo.

Zviratidzo zvekushaya ropa zvinosanganisira:

Musoro wakareruka
Dzungu
Kuneta
Ganda rakachenuruka
Maoko anotonhora nemakumbo
Zvipikiri zvinopwanyika

Usati wamira kutora metformin

Kana mumwe munhu akatanga kutora metformin, zvakakosha kuti utarise njodzi dzekumisa mishonga nekukasira. Varwere vanofanira kugara vachitaura nachiremba wavo vasati vamira chero mushonga sezvo paine mukana wekuti zviratidzo kana mamiriro avo anogona kutonyanya. Chiremba anoona nzira yakachengeteka yekuchinja kune imwe antidiabetic mishonga, senge sulfonylurea, kana kuraira maitiro ekugadzira anodiwa mararamiro shanduko.

Kuti uone kuti yakawanda sei yaunogona kuchengetedza pane yako metformin kana Glucophage tsamba, tarisa SingeCare's yakasarudzika mitengo pano .