Kuru >> Nhau >> Sangana naUbrelvy, iyo nyowani FDA-inogamuchirwa mishonga inorapa migraine

Sangana naUbrelvy, iyo nyowani FDA-inogamuchirwa mishonga inorapa migraine

Nhau

Mune angangoita 1 mune mana eUS dzimba, mumwe munhu anotambura nemagraine, sekureva kwe Migraine Research Foundation . Uye vazhinji veavo vakakanganiswa havana kuwana mushonga unoshanda. Zvino, pane nyowani migraine kurapwa sarudzo padhuze. Iyo FDA ichangobvumidza Ubrelvy (ubrogepant), mushonga unoita nekukurumidza kubatsira kupfupisa kureba kwemigraines.

Chii chinonzi migraine?

Migraine haisi kungorwadziwa nemusoro zvakanyanya. Muchokwadi, migraine inonzi se chirwere chechitanhatu chinoremadza pasi rose. Kunze kwekurwadziwa kwakanyanya kwemusoro, kusagadzikana kwekuona, kuda kurutsa, kurutsa, dzungu, kunetseka zvakanyanya kurira, kupenya, kubata uye kunhuwidza, uye kurira kana kupera mukati memucheto kana kumeso zvinowanzo fambidzana nemagraines.

Migraines yakajairika zvakadii?

12% yevagari - kusanganisira gumi muzana yevana - vanoona migraines. Zvinokanganisa 18% yevakadzi veAmerica uye 6% yevarume. Pakazara, avo vanopfuura mamirioni mana vanhu vane chisingaperi chemazuva ese migraine uye vanoziva anopfuura mazuva gumi nemashanu emigraine pamwedzi.

Migraine mishonga

Kune mishonga yakawanda yemishonga inowanikwa kudzivirira migraine, uye kurapa zviratidzo kana imwe yatanga. Uye zvakare, varapi dzimwe nguva vanokurudzira shanduko yemararamiro (sekuderedza kusagadzikana kana kudzimisa mwenje), kurudzira varwere kutora pamusoro-the-counter kana simba rekunyorerwa NSAIDs (senge ibuprofen kugadzirisa marwadzo, kunyorera antipsychotic, antidepressants, antiepileptic zvinodhaka, beta blockers, uye kunyangwe kuraira varwere kuti vagamuchire. Botox majekiseni kudzikamisa kuwanda uye zviratidzo zvemigraines yavo.

Chii chinonzi Ubrelvy (ubrogepant)?

Ubrelvy (ubrogepant) ndiyo yazvino kurapwa kwemigraines (ine kana isina aura). Iyo inorapa yekurapa, zvichireva, ndiyo nguva yekutanga iyi kirasi yemishonga kubvumidzwa kurapa migraines. Iyo inogona kuve inoshandura hupenyu hupenyu kune varwere vasina kuwana zororo kubva kune aripo madhiragi.

Iyo FDA-inogamuchirwa mishonga inoratidzirwa kuchipatara kupfupisa kureba kwemigraine episodes, pamwe nekuderedza marwadzo uye zviratidzo zvinosangana nazvo. Inoshanda nekudzivirira mhedzisiro yecalcitonin gene-inoenderana peptide (CGRP) receptor. CGRP yakaratidzirwa kuve chinhu chimwe chemukati chinokonzeresa nekusimudzira migraines. Uye kunyangwe paine mimwe mishonga - majekiseni ane zita rekuti Aimovig , Kusimba , uye Ajovy -Izvo zvinodzivirira migraines nekuvharira CGRP, Ubrelvy inomira yakaparadzana nekuti mushonga wemuromo unoshanda kupora migraines kana atove kutoitika. Iyo inouya nemhando mbiri dzekuisa dosing (50 uye 100 mg mahwendefa) kupa shanduko kune izvo zvinodiwa nevarwere uye kugadzirisa kushanda kwehuwandu hwevanhu.

Ubrelvy akapasa kiriniki miedzo uye bvunzo, izvo zvakatungamira mukubvumidzwa kwayo kwekupedzisira kubva kuhutungamiriri. Zvinoenderana neiyo FDA, kushanda kwemushonga kwakaratidzirwa mune mbiri dzakasarudzika, mbiri-bofu, miedzo inodzorwa ne placebo. Munguva yezvidzidzo, 1,439 vakuru varwere vane nhoroondo yemigraine (ine uye vasina aura) vakagamuchira madhizaji akagamuchirwa eUbrelvy kurapa inoenderera mberi migraine.

Muzvidzidzo zvese izvi, vangangoita 19% yevarwere vanonzwa kusanzwa kurwadziwa maawa maviri mushure mekurapwa (kunotsanangurwa sekudzikiswa kwekushungurudzika kwemusoro kubva pakurwadziwa kwakanyanya kana kwakanyanya kusava nekurwadziwa) uye 38.6% vakashumwa kunzwa kuzorodzwa kwakakwana kubva kuchiratidzo chavo chinonetsa zvikuru chemigraine (kuda kurutsa , kunzwisisika zvishoma, kana kunzwika kwekunzwa) maawa maviri mushure mekurapwa Izvi zvikamu zvakakwirira zvakanyanya pakati pevarwere vanogamuchira Ubrelvy (pane chero dosi) zvichienzaniswa neavo vakagamuchira placebo.

Iwo akanyanya kukanganisika mhedzisiro yeUbrelvy ndeyekushungurudzika uye kushushikana (kuneta).

Seyekutanga gepant yemuromo, Ubrelvy inopa nyowani uye yakasarudzika mhando yekurapa kwakanyanya sarudzo kune vanhu vanorarama nekurwadzikana uye zvimwe zviratidzo zvemigraine, David Nicholson, mutevedzeri mutevedzeri wemutungamiri uye mukuru weR&D mukuru wekambani yerezinesi yeUbrelvy, Allergan, akadaro mune kuburitswa . Yayo yemumuromo manejimendi ine maviri madhizaini masimba inobvumira kurapwa kuchinjika uye kurerukirwa kana migraine kurwisa kukaitika. Sezvo isu tichiramba tichityaira hunyanzvi mukurapa kwemigraine, isu tinodada kupa varwere imwe sarudzo, uye tine chivimbo kuti ichaita mutsauko kune avo vanoshaya. KuAllergan, isu tinotenda kuti varwere ve migraine vanokodzera kuwana mishonga mitsva yese yeichi chirwere chinoparadza.