FDA inobvumidza Trijardy XR yerudzi rwechipiri chirwere cheshuga
NhauNhau dzakanaka kune vakuru vane mhando 2 chirwere cheshuga: Une nzira nyowani yekurapa inowanikwa kudzikisa shuga yeropa. IU.S. Food and Drug Administration (FDA) yakazivisa tendero yeTrijardy XR. Iyo itsva katatu-yekubatanidza piritsi inosanganisira matatu mishonga yeshuga mune kamwe-zuva nezuva mushonga:
- Glucophage ( metformin HCl ), inova
- Tradjenta (linagliptin), dipeptidyl peptidase-4 (DPP-4) inhibitor
- Jardiance (empagliflozin), sodium-glucose co-transporter 2 (SGLT2) inhibitor
Iyi piritsi haisiri mushonga mutsva-ingori yekumisazve marapirwo matatu aripo, anodaro Dr. Marie Bellantoni, board-Certified endocrinologist muThe Center for Endocrinology paMercy Medical Center muBaltimore, Maryland.
Nekudaro, iyo yekureruka chinhu inogona kuve inonakidza kwazvo.
Kusvika padanho rekuti chero chinhu chinovandudza kunamatira kwemurwere kumishonga kwakanaka - mapiritsi haashande kana akasapinda mumurwere - saka izvi zvinobatsira, anodaro Dr. Bellantoni. Vamwe vanhu vanonzwa kushomeka zvakanyanya kana vari kutora mapiritsi mashoma.
Chii chinonzi Trijardy XR?
Mimwe yemishonga iri muTrijardy XR inogona kurira kunge yakajairika kwauri, kana iwe kana munhu waunoda uine chirwere cheshuga chechipiri. Iwe unogona kunge wakatora imwe kana zvese izvi pane imwe nguva.
Metformin inowanzo gadzwa seyekutanga-kurapwa kurapwa kwevanhu vane mhando 2 chirwere cheshuga. Inobatsira kudzikisa mashuga eropa nekuderedza insulin yemuviri wako. Iyo zvakare inoderedza huwandu hweshuga inogadzirwa nechiropa chako uye kutora kwemuviri wako shuga. Vamwe vanhu vanotora metformin voga, asi vamwe vanofanirwa kuitora pamwe nemimwe mishonga yeshuga.
Tradjenta yakagadzirirwa kubatsira vanhu vane chirwere cheshuga chechipiri kubata mashuga eropa, pamwe nekurovedza muviri uye kudya. Inobatsira kudzikisa huwandu hweshuga yeropa nekudzikisa huwandu hweshuga yakaburitswa nechiropa uye nekuwedzera huwandu hweinsulini inogadzirwa nepancreas. Inowanzo gadzirirwa vanhu vari kutotora mishonga yeshuga uye vachichinja mararamiro avo asi vachiri kuda rubatsiro kuti vabudirire tarisiro yavo A1C. (A1C inoyera huwandu hweshuga yeropa yemunhu pamwedzi mitatu-yakatambanudzwa.) Inowanikwawo muhwendefa kamwe chete-rezuva nezuva.
Jardiance mumwe mushonga unogona kubatsira vanhu kudzikisa shuga yavo pamwe nekudya uye kurovedza muviri, asi zvinogona zvakare kudzora njodzi yekufa kwemoyo muvanhu vane chirwere cheshuga chirwere cheshuga. Iyo ipiritsi kamwe-zuva nezuva rinouya muzvimiro zviviri (10 mg uye 25 mg) uye inogona kutorwa pamwe chete nemimwe mishonga yakawanda, inosanganisira metformin, insulin, beta blockers, ACE inhibitors, uye statins.
Trijardy XR dosages
Trijardy XR, inotengeswa naBoehringer Ingelheim Pharmaceuticals, Inc. naEli Lilly neKambani, ichave ichiwanikwa mumadhigisi mana:
- 5 mg empagliflozin, 2.5 mg linagliptin, 1000 mg metformin HCl yakawedzerwa-kuburitswa
- 10 mg empagliflozin, 5 mg linagliptin, 1000 mg metformin HCl yakawedzerwa-kuburitswa
- 12.5 mg empagliflozin, 2.5 mg linagliptin, 1000 mg metformin HCl yakawedzerwa-kuburitswa
- 25 mg empagliflozin, 5 mg linagliptin, 1000 mg metformin HCl yakawedzerwa-kuburitswa
Sekureva kwevagadziri, Trijardy XR ndiyo yekutanga piritsi-yekubatanidza piritsi yekubatanidza Jardiance. Jardiance yakatanga kubvumidzwa neDFA muna2014, asi kubvumidzwa kwaive yakawedzera mukupera kwa2016 kubvuma kushandiswa kwayo kudzikisa njodzi yekufa kwemoyo.
Trijardy XR yambiro
Trijardy XR haina kuitirwa vanhu vane chirwere cheshuga 1 kana vanhu vane chirwere cheshuga ketoacidosis. Mugadziri anoyambira kuti iyo mushonga hauna kuongororwa muvanhu vane pancreatitis , saka hazvikurudzirwe kune vanhu vane mamiriro akadaro. Mugadziri anoyambirawo vanhu vanokudziridza zviratidzo zve metformin-inosanganisirwa lactic acidosis kurega kutora mushonga ipapo ipapo. Izvo hazvifanirwe zvakare kushandiswa kune avo vane zvakakomba itsvo nyaya, yekupedzisira-nhanho renal chirwere, kana avo vari pane dialysis.
Imwe inogona kuve yakadzikira yeatatu-musanganiswa med zvingave zvakaoma kuti uone kuti ndeupi mushonga unoshanda kana iwe ukawana mhinduro yakaipa, anodaro Dr. Bellantoni.
Iko kushandisa zvine hungwaru kwemishonga mitatu-yemusanganiswa kwaizove mushure mekunge murwere aratidza kushanda uye kushivirira kwemishonga yakapihwa zvakasiyana, anodaro, zvino vanonyatsotenda kudzikisa huwandu hwekunyorerwa kudzoreredza kopi dzavanofanira kugadzira.
Zvakadaro, iri kuvimbisa nyowani yekurapa sarudzo. Tinotenda Trijardy XR ine mukana wekubatsira vanhu vakuru vane mhando 2 chirwere cheshuga kubata marapirwo avo, kunyanya avo vari kutora mimwe mishonga uye vachishanda panzira inodiwa yekuchinja mararamiro, Dr. Mohamed Eid, mutevedzeri wemutungamiri weKiriniki Yekuvandudza uye Zvekurapa, Cardio- Metabolism uye Respiratory Mishonga yeBoehringer Ingelheim Pharmaceuticals, Inc. yakati mune chirevo chinozivisa kubvumidzwa.
