Trulance vs. Linzess: Misiyano, kufanana, uye izvo zviri nani kwauri
Zvinodhaka Vs. ShamwariKuongorora kwemishonga & misiyano mikuru | Conditions kurapwa | Kubudirira | Inishuwarenzi kufukidza uye mutengo kuenzanisa | Zvimwe zvinokanganisa | Kubatana kwezvinodhaka | Yambiro | MIBVUNZO
Trulance (plecanatide) uye Linzess (linaclotide) mishonga miviri inogona kushandiswa pakurapa chirwere chinoshatisa ura (IBS). Ose madhiragi aya anosimudzira ura nekuwedzera huwandu hwemvura mumatumbu. Padanho rezvemakemikari, Trulance uye Linzess vanoita semagonist eguanylate cyclase-C zvinogamuchirwa mumatumbu. Izvi, zvakare, zvinowedzera mutoro wemvura, zvinyoro nyoro machira, uye zvinomhanyisa kufamba kwechikafu.
Trulance uye Linzess zvakaratidzirwawo mukurapa kwekusingaperi idiopathic kuvhiringidzwa (CIC). Iyi ndiyo mhando yekuzvimbirwa iyo isina chikonzero chinozivikanwa.
Ose maviri emishonga yekudzivirira-kudzikisira inoda kushanyirwa nachiremba uye mushonga. Trulance neLinzess zvinopesanawo muvana vari pasi pemakore matanhatu ekuberekwa. Izvo hazvikurudzirwe kune chero munhu ari pasi pemakore gumi nemasere ekuberekwa.
Ndeupi mutsauko mukuru pakati peTrulance neLinzess?
Kunyangwe vese Trulance neLinzess vachiita pane iyo guanylate cyclase-C zvinogamuchirwa , vane mazita akasiyana akajairwa uye zvinoshandiswa zvinoshandiswa. Trulance ndiro zita rekuti plecanatide nepo Linzess iri zita rezita re linaclotide.
Trulance mushonga mutsva kupfuura Linzess uye unogona kutorwa uine kana usina chikafu. Linzess inowanzo kutorwa pane isina chinhu dumbu maminetsi makumi matatu pamberi pekudya kwekuseni. Ipo Trulance ichiwanikwa se3 mg yemuromo piritsi, Linzess inowanikwa seyemuromo kapuru mune akasiyana masimba.
| Misiyano mikuru pakati peTrulance neLinzess | ||
|---|---|---|
| Trulance | Linzess | |
| Kirasi Yezvinodhaka | Guanylate cyclase-C agonist | Guanylate cyclase-C agonist |
| Brand / generic chinzvimbo | Hapana generic vhezheni iripo | Hapana generic vhezheni iripo |
| Zita Rokuzvarwa | Plecanatide | Linaclotide |
| Generic Fomu Kuwanikwa | Haisipo | Haisipo |
| Ndeapi mafomu (s) ayo mushonga unouya? | 3 mg yemuromo piritsi | 72, 145, 290 mcg macommule capsules |
| Ndeipi muyero wakajairwa? | Ne kana pasina chikafu, kamwe pazuva. | Inofanira kutorwa pasina chinhu mudumbu, kamwe pazuva. |
| Yakareba sei iyo yekurapa? | Nguva yakareba zvichienderana nemutemo wechiremba wako | Nguva yakareba zvichienderana nemutemo wechiremba wako |
| Ndiani anowanzoshandisa mushonga? | Vakuru vane makore gumi nemasere zvichikwira | Vakuru vane makore gumi nemasere zvichikwira |
Unoda yakanakisa mutengo paTrulance?
Saina kuti Trulance yemutengo yambiro uye uone kana mutengo uchinja!
Wana machenjedzo emitengo
Mamiriro ezvinhu akarapwa neTrulance neLinzess
Linzess uye Trulance zvakagamuchirwa kuti zvishandiswe mu kusingaperi kuzvimbirwa uye iyo yekuzvimbirwa-yakakurisa mhando yeinoshatisa bowel syndrome (IBS-C). Kuburikidza nezviito zvavo pane zvemukati matumbu zvinogamuchira, ese ari maviri madhiragi anosimudzira kuyerera kwemvura uye nekuwedzera kwekufamba kwechikafu kuburikidza neguvhu.
Izvi mishonga-mishonga hazvisi marara. Izvo hazvipe izvo pakarepo zororo kubva kuzvimbirwa. Mhedzisiro inowanzoonekwa mushure mevhiki rekurapwa neTrulance neLinzess. Ivo anowanzo chengetedzwa kwekushandisa kwenguva refu.
Trulance uye Linzess dzimwe nguva dzinogona kushandiswa kure-chiraira pakurapa opioid-indipipiti yekuzvimbirwa (OIC) inokonzerwa nemishonga yakaita se morphine. Zvimwe zvisiri-zvinoratidza zvinoratidza zvinosanganisira ulcerative colitis.
| Mamiriro | Trulance | Linzess |
| Irritable bowel syndrome nekuzvimbirwa | Ehe | Ehe |
| Chisingaperi idiopathic kupatirwa | Ehe | Ehe |
| Opioid-inokonzera kupatira | Kunze-chitaridzi | Kunze-chitaridzi |
| Ulcerative Colitis | Kunze-chitaridzi | Kunze-chitaridzi |
Trulance kana Linzess inoshanda here?
Trulance mushonga mutsva kana uchienzaniswa neLinzess. Zvisinei, kushanda kwemaviri emishonga iyi kwakanyanya kana kushoma zvakaenzana.
Kuvandudzwa kwehuwandu hwekufamba kwematumbo kunoonekwa senge svondo rimwe riine simba rezvenguva refu. Pamwe pamwe nekuwedzera kwehuwandu hwekufamba kwehurosi, iyi mishonga zvakare inovandudza mhando yechigaro kusanganisira stool dhizaini uye kuenderana.
Iko kushanda kweTrulance mune imwe kliniki kuyedzwa yakawanikwa ichinyanya kutaurwa pakurapa kusingaperi idiopathic kuvhiringidzwa. Inofananidzwa ne placebo, Trulance yakaratidzwawo kuti inoshanda pakurapa chirwere chinoshungurudza ura.
Parizvino, pane zvidzidzo zvishoma zvekuenzanisa pakati peLinzess neTrulance maererano nekushanda kwavo asi zvese zviri zviviri zvinonyanya kushanda kupfuura mishonga ye placebo yekubvisa kupatira. Poshi kuongorora kwakarongeka vakawana kuti Trulance neLinzess vane zvakafanana kushanda pamwe nekuchengetedza. Pakanga pasina misiyano yakakosha mukuitika kwemhedzisiro senge manyoka.
Sarudzo yemushonga wesarudzo inogona kutemwa chete nachiremba. Mushure mekuongorora kwakakwana, chiremba achapa mushonga wakanakisa wakanangana nemamiriro ezvinhu emunhu wese.
Unoda akanakisa mutengo paLinzess?
Sign up kune Linzess mutengo chenjedzo uye tsvaga kuti kana mutengo wachinja!
Wana machenjedzo emitengo
Kuvhavha uye mutengo kuenzanisa kweTrulance vs. Linzess
Trulance yakagamuchirwa muna2017 sezita-zita chete mushonga. Izvozvi inogadzirwa neSynergy Pharmaceuticals. Ikozvino hapana generic vhezheni iripo. Medicare uye mazhinji marongero einishuwarenzi anogona kunge asingavhare Trulance. Ivhareji yemari mutengo weTrulance inogona kudarika $ 500. Kushandisa kadhi reSingCare rekudzora kunogona kubatsira kuunza mutengo pasi pasi pe $ 400. Kunyange ichiri mushonga unodhura, kushandisa kadhi rekudzikisira kunogona kuunza mutengo pasi apo inishuwarenzi isingagoni kuifukidza.
Linzess yakagamuchirwa muna 2012 uye inongowanikwa chete sezita-zita mushonga. Kunge mamwe guanylate cyclase-C agonists, Linzess inogona kunge ichidhura kwazvo neavhareji yekutengesa mutengo unopfuura madhora mazana mashanu. Neraki, mamwe maMedare uye zvirongwa zveinishuwarenzi zvinogona kuzvivhara. Kunyangwe neinishuwarenzi, iwe unogona kukwanisa kusevha yakawanda neSingleCare kadhi rekudzora iro rinogona kudzikisira mutengo kusvika kumadhora mazana mana.
| Trulance | Linzess | |
| Kazhinji yakafukidzwa neinishuwarenzi? | Kwete | Kwete |
| Inowanzo kufukidzwa neMedare? | Kwete | Kwete |
| Standard muyero | 3 mg mapiritsi | 72, 145, 290 mcg capsules |
| Chaizvoizvo Medicare copay | $ 70- $ 474 | $ 19- $ 482 |
| SingleCare mutengo | $ 389. + | $ 403.38 |
Zvakajairika mhedzisiro mhedzisiro yeTrulance vs. Linzess
Iyo yakajairika mhedzisiro mhedzisiro inosangana nekushandisa Trulance kana Linzess chirwere. Nekuda kwehunhu hwebasa ravo, iyi mishonga inonyanya kukonzera dumbu mhedzisiro mhedzisiro. Zvinoenderana nemazita avo echirwere cheDFA, Trulance inogona kuve nemhedzisiro yakaenzana kana ichienzaniswa neLinzess. Huru divi mhedzisiro yeTrulance manyoka.
Zvimwe kunze kwemanyoka, Linzess inogona kukonzeresa mimwe mhedzisiro mhedzisiro senge kubhowa, flatulence, uye kurwadziwa nemudumbu.
Muzviitiko zvisingawanzoitika, Trulance uye Linzess zvinogona kukonzera manyoka akakomba. Mune zviitiko izvi, chiremba wako anokurudzira kurambidza kwechimbichimbi kwechirwere. Muvana, iyi mishonga inogona kukonzera kupera simba kwakanyanya. Naizvozvo, ivo havana kukurudzirwa muvana.
| Trulance | Linzess | |||
| Side Migumisiro | Zvinoshanda? | Kakawanda | Zvinoshanda? | Kakawanda |
| Manyoka | Ehe | 5% | Ehe | makumi maviri% |
| Marwadzo emudumbu | Ehe | <2% | Ehe | 7% |
| Bloating | Ehe | <2% | Ehe | piri% |
| Kubata ropa | Ehe | <2% | Ehe | 4% |
| Kutemwa nemusoro | Kwete | - | Ehe | 4% |
Izvi zvinogona kunge zvisiri runyorwa ruzere rwemhedzisiro mhedzisiro inogona kuitika. Ndokumbira utarise kuna chiremba wako kana mupi wezvehutano kuti udzidze zvimwe.
Kunobva: Zuva Nezuva ( Trulance ), Zuva Nezuva ( Linzess )
Kubatana kwezvinodhaka zveTrulance vs. Linzess
Kune mashoma mashandisirwo emishonga neTrulance. Inowanzoonekwa seyakachengeteka kutora nemimwe mishonga. Nekudaro, mumwe mushonga, kunyanya, une mukana wekubatana neTrulance. Idelalisib inoratidzirwa pakurapa kweimwe kanzira yeropa senge chisingaperi leukemia.
Idelalisib, kana ikatorwa neTrulance, inogona kukonzera manyoka akanyanya, anotyisidzira hupenyu. Izvo zvakakosha kuti ubate wako wehutano mutapi nekukasira kana iwe ukaona zviratidzo zvekudyidzana kwemushonga.
Kunze kwedelalisib, hapana kumwe kudyidzana kwakakosha kwezvinodhaka neTrulance. Izvo hazvipindire iyo cytochrome P450 enzyme yakaoma uye haina kukanganisa kune vamwe maseru anotakura.
Linzess, kune rimwe divi, ane runyorwa rurefu rwekupindirana kwezvinodhaka zvichienzaniswa neTrulance. Mushonga uyu une mukana wekubatana nemimwe mishonga yakadai selevothyroxine, bisacodyl, psyllium, magnesium hydroxide, uye omeprazole.
| Zvinodhaka | Kirasi Yezvinodhaka | Trulance | Linzess |
| Idealisib | Phosphoinositide 3-kinase inhibitor | Ehe | Hazvina kutaurwa |
| Levothyroxine | Uturu hwehomoni | Hazvina kutaurwa | Ehe |
| Bisacodyl | Stimulant laxative | Hazvina kutaurwa | Ehe |
| Psyllium | Fiber laxative | Hazvina kutaurwa | Ehe |
| Magnesium hydroxide | Saline laxative | Hazvina kutaurwa | Ehe |
| Omeprazole | Proton pombi inhibitor | Hazvina kutaurwa | Ehe |
Iri harisi runyorwa ruzere rwekubatana kwezvinodhaka. Ndokumbirawo ubvunze chiremba wako usati watora iyi mishonga.
Yambiro dzeTrulance vs. Linzess
Zvese Trulance neLinzess zvine mukana wekukonzera zvakakomba mhedzisiro, kunyanya manyoka uye kupera mvura mumuviri.
Muvana vari pasi pemakore matanhatu ekuberekwa, mishonga iyi ine njodzi yekukonzera kushaya simba kwakanyanya. Kuchengetedzeka kwavo uye kugona kwavo hakuna kunyatso kusimbiswa muvana vadiki pane makore gumi nemasere, ndosaka vese Trulance neLinzess vachipikiswa nevarwere vevana. Kushaya mvura mumuviri kunogona kuitika semhedzisiro yekuwedzera kukurudzira kweiyo guanylate cyclase-C zvinogamuchirwa zvinowedzera hutumbo motility uye kuyerera kwemvura pane yakakwira-kupfuura-yakajairwa mwero.
Ivo vane gastrointestinal blockage (kuvharirwa) vanofanirwa kudzivirira kutora Trulance kana Linzess. Taura nachiremba kuti uone kana uine dumbu rekuvhara usati watora chero mushonga.
Dhairrhea ndeimwe yakajairika mhedzisiro mhedzisiro uye njodzi inogona kuitika nekushandiswa kweZviri Trulance neLinzess. Chirwere chemanyoka hachigone kukonzera kukonzera kupera simba kwemvura asiwo kukanganisa kwemagetsi mumuviri. Izvi zvinogona kuda kumwe kurapwa kana zvisina kugadziriswa nenzira kwayo.
Trulance uye Linzess hazvina kuongororwa mumadzimai ane nhumbu kana kuyamwisa. Ivo vanofanirwa kushandiswa chete mushure mekuongorora mikana ingangoita yekuremara kwekuzvara.
Inowanzo bvunzwa mibvunzo nezve Trulance vs. Linzess
Chii chinonzi Trulance?
Trulance mushonga wekurapa uyo unobvumidzwa pakurapa kupatirwa-kwakanyanya kunoshatisa ura (IBS-C) uye chisingaperi idiopathic kuvhiringidzwa (CIC). Iyo guanylate cyclase-C receptor agonist iyo inowedzera kufamba kwemukati. Trulance yakachengeteka kushandisa kune varwere vakura kupfuura makore gumi nemasere ekuberekwa. Iyo inouya mune yemuromo piritsi fomu ine zororo inowanzoonekwa mukati mevhiki rekushandisa.
Chii chinonzi Linzess?
Linzess mushonga wekare unoita nenzira imwecheteyo seTrulance. Iyo guanylate cyclase-C receptor agonist iyo inowedzera kufamba mumatumbu uye kubvisa kuzvimbirwa. Neichi chikonzero, Linzess yakave yakatenderwa yeinoshatisa bowel syndrome-C uye kusingaperi kuzvimbirwa. Icho chinodhaka chemushonga chinowanikwa mune yemuromo kapuleti fomu.
Trulance neLinzess zvakafanana here?
Kwete. Kunyangwe vari veboka rimwe chete remishonga, iyi mishonga inouya nenzira dzakasiyana dzedosi. Trulance mushonga mutsva unogona kutorwa pamwe kana pasina chikafu. Linzess inofanirwa kutorwa isina chinhu mudumbu maminetsi makumi matatu usati wadya.
Ndezvipi zviri nani – Trulance kana Linzess?
Trulance neLinzess vane zvakafanana kushanda pamwe nekuchengetedza. Nekudaro, Linzess inogona kuve yakabatana neakakwira chiitiko chehurwere, kuputika, uye gasi. Neichi chikonzero, Trulance inogona kusarudzwa kupfuura Linzess.
Ndinogona here kushandisa Trulance kana Linzess ndichiri nepamuviri?
Hazvisati zvazivikanwa kuti Trulance kana Linzess dzakachengeteka kutora panguva yepamuviri kana lactation. Iwe unofanirwa kubvunza chiremba usati watora iyi mishonga kana uine pamuviri kana kuyamwisa.
Ndinogona here kushandisa Trulance kana Linzess nedoro?
Kubatana kwezvinodhaka zveTrulance kana Linzess nedoro hazvina kunyatso simbiswa. Iko kune mukana wekuti kunwa doro nemishonga iyi kunogona kuwedzera njodzi yezviitiko zvakashata.
Amitiza ari nani kupfuura Linzess?
Kuenzaniswa kamwechete-zuva nezuva Linzess, Amitiza (lubiprostone) inoda kutorwa kaviri zuva nezuva. Amitiza inogona zvakare kuve yakajairika mhedzisiro mhedzisiro kana ichienzaniswa neLinzess. Mukuwedzera kune manyoka, Amitiza ine mukana wekukonzeresa kusvotwa, kuzvimba, uye nekuoma muromo.
Ndeipi iyo generic vhezheni yeLinzess?
Ikozvino hapana generic vhezheni yeLinzess inowanikwa pamusika.
Ndezvipi zvirinani kupatirwa-Linzess kana Trulance?
Dzese Trulance neLinzess dzakaratidzirwa kunge dzakaenzana mukubudirira uye chengetedzo. Mumwe mushonga unogona kusarudzwa pane mumwe zvichienderana nemutengo uye inishuwarenzi kufukidzwa. Trulance zvakare iri nyowani mushonga ine mashoma akataurwa zvakajairika mhedzisiro.
Linzess achaita kuti urasike uremu here?
Huremu shanduko dzinogona kuitika kana uchitora Linzess. Linzess yakanzi inokonzera kuonda kana kuwedzera huremu.
