Amitiza vs.Linzess: Misiyano, kufanana, uye izvo zviri nani kwauri
Zvinodhaka Vs. ShamwariKuongorora kwemishonga & misiyano mikuru | Conditions kurapwa | Kubudirira | Inishuwarenzi kufukidza uye mutengo kuenzanisa | Zvimwe zvinokanganisa | Kubatana kwezvinodhaka | Yambiro | MIBVUNZO
Amitiza naLinzess mishonga miviri yemishonga inoshandiswa pakurapa chirwere chisingaperi chinonzi idiopathic constipation (CIC) uye chinokanganisa bowel syndrome nekuzvimbirwa (IBS-C). Chisingaperi idiopathic kuvhiringidzika kunoonekwa nenguva yemwedzi mitanhatu kana kureba nemitatu kana mishoma yekufamba kwega kwega kwevhiki. Irritable bowel syndrome iboka rezviratidzo zvakasiyana zvinoitika pamwechete kusanganisira kurwadziwa mudumbu uye shanduko mukufamba kwematumbu: manyoka, kuzvimbirwa, kana zvese zviri zviviri. Amitiza neLinzess zvinoshandiswa zvakanyanya muIBS nekuumbirwa. Tichakurukura kufanana uye mutsauko uripo pakati peAmitiza naLinzess pano.
Ndeupi mutsauko mukuru pakati peAmitiza neLinzess?
Amitiza (lubiprostone) mushonga unorapwa unobata kuzvimbirwa nekuwedzera hutumbu hwemvura. Iyo bicyclic fatty acid uye prostaglandin E1 (PGE 1) inogadzira iyo inoita kuti chloride chiteshi mumatumbo mudumbu. Iko kukonzeresa kwekuwedzera kwekuvanzika kunoshandura chigaro kusagadzikana uye kunosimudzira kugara uchiita matumbu. Amitiza inowanikwa seyemuromo softgel capsule musimba re8 mcg uye 24 mcg.
Linzess (linaclotide) mushonga wekurapa unoratidzwa zvakare kurapa kupatira. Iyo guanylate cyclase C (GC-C) agonist iyo inokonzera kuwedzera kwecyclic guanosine monophosphate (cGMP). Kuita pane iyo GC-C receptor kunoguma nekuwedzera kwematumbo secretions. Izvi zvinokonzeresa kuwedzera kwematumbo emvura uye zvinowedzera motility yezvinhu zvemukati kuburikidza neturakiti. Kuwedzera kweiyo cGMP mazinga anofungidzirwawo kupindirana nekudzikisira kurwadziwa kwekuona mudumbu kunozivikanwa muBS. Linzess inowanikwa seyemuromo capsule musimba re 72 mcg, 145 mcg, uye 290 mcg.
| Misiyano mikuru pakati peAmitiza naLinzess | ||
|---|---|---|
| Amitiza | Linzess | |
| Kirasi yemishonga | Bicyclic fatty acid / PGE 1 inotora / chloride chiteshi activator | Guanylate cyclase C agonists |
| Brand / generic chinzvimbo | Brand chete | Brand chete |
| Chii chinonzi generic zita? | Lubiprostone | Linaclotide |
| Ndeapi mafomu (s) ayo mushonga unouya? | Oral softgel Kamudzira | Oral capsules |
| Ndeipi muyero wakajairwa? | 24 mcg kaviri pazuva | 145 mcg kamwe pazuva |
| Yakareba sei iyo yekurapa? | Isingagumi, kwenguva refu | Isingagumi, kwenguva refu |
| Ndiani anowanzoshandisa mushonga? | Vakuru | Vakuru |
Mamiriro ezvinhu anorapwa naAmitiza naLinzess
Amitiza naLinzess imwe neimwe inoratidzirwa pakurapwa kwechirwere chisingaperi chisingadzvinyiriri pamwe nekutsamwa kwematumbu chirwere nekuzvimbirwa. Amitiza inobvumidzwawo neKudya neDrug Administration (FDA) mukurapa kuzvimbirwa kunokonzerwa neopioid pain reliever use in chronic, non-cancer pain. Izvi dzimwe nguva zvinonzi OIC, opioid-inokonzera kupatira.
Amitiza naLinzess imwe neimwe inongoratidzwa kuti ishandiswe muvakuru, uye kushandiswa muvana nevechiri kuyaruka hakubvumidzwe. Chiremba wako chete ndiye anogona kusarudza kana mishonga iyi iri sarudzo chaiyo yemamiriro ako.
| Mamiriro | Amitiza | Linzess |
| Chisingaperi idiopathic kupatirwa | Ehe | Ehe |
| Irritable bowel syndrome nekuzvimbirwa | Ehe | Ehe |
| Opiate agonist-inokonzera kupatira (kusingaperi, kusiri-kenza kurwadziwa) | Ehe | Kwete |
Amitiza kana Linzess inoshanda here?
TO kuongorora kwakarongeka ye21 randomized inodzorwa kiriniki miedzo ichifananidza zvinoshandiswa zvinoshandiswa zveAmitiza, Linzess, uye mamwe marapirwo ekurapa. Dzimwe nzira dzekurapa dzakabatanidzwa muchidzidzo ichi yaive prucalopride, tegaserod, bisacodyl, uye polyethylene glycol (PEG). Kuongorora uku kwakapedzisa kuti zvese zvaisanganisira madhiragi airatidza kushanda kwakaringana pamusoro penzvimbo dzepamoyo kana uchiongorora magumo ekuva ne3 kana zvimwe zvinofamba ura pavhiki. Bisacodyl, yekuwedzera-the-counter inosimudzira laxative, yaive yepamusoro kune ese Amitiza neLinzess maererano neshanduko muhuwandu hwekufamba kwemukati pavhiki. Anodzvinyirira laxatives anogona kukonzeresa kusaenzana kwe electrolyte uye anowanzoitika mukusimudzira kwekushivirira nekufamba kwenguva.
Anonyorera angangoda kutarisa zvinhu zvakaita sezviitiko zvakashata, kudyidzana kwezvinodhaka, uye kutevedzera kamwechete zuva nezuva kana kaviri pazuva dosing kana uchisarudza kuti ndeupi mushonga wakanakira murwere.
Kuvhavha uye mutengo kuenzanisa kweAmitiza vs. Linzess
Amitiza inowanzo kufukidzwa nezvose zviri zviviri zvekutengesera uye Medicare Chikamu D zvirongwa zvemushonga, asi mune zvimwe zviitiko zvingangodawo kupihwa mvumo yekutanga kufukidzwa. Mutengo wekunze kwehomwe weAmitiza unogona kusvika pamadhora mazana masere nemakumi maviri nemaviri, asi koponi kubva kuSingleCare inogona kudzikisa mutengo kusvika kumadhora zana nemakumi matanhatu nenomwe pazuva makumi matatu.
Linzess inowanzo kufukidzwa nezvose zviri zviviri zvekutengeserana uye Medicare Chikamu D zvirongwa zvemushonga, asi mune zvimwe zviitiko zvingangodawo kupihwa mvumo yekutanga kufukidzwa. Pasina chero mhando yekuvhara, Linzess inogona kuita ingangoita madhora mazana matanhatu nemakumi mana. Iyo Linzess coupon kubva kuSingleCare ichakubatsira iwe kuchengetedza paLinzess, uye iwe unogona kubhadhara zvishoma seUS $ 395.
| Amitiza | Linzess | |
| Kazhinji yakafukidzwa neinishuwarenzi? | Ehe, dzimwe nguva nemvumo yepamberi inodikanwa | Ehe, dzimwe nguva nemvumo yepamberi inodikanwa |
| Inowanzo kufukidzwa neMedare Chikamu D? | Ehe, dzimwe nguva nemvumo yepamberi inodikanwa | Ehe, dzimwe nguva nemvumo yepamberi inodikanwa |
| Zvakawanda | 30, 24 mcg capsules | 30, 145 mcg capsules |
| Chaizvoizvo Medicare copay | Zvinosiyana zvichienderana nechirongwa | Zvinosiyana zvichienderana nechirongwa |
| SingleCare mutengo | $ 176- $ 204 | $ 395– $ 470 |
Tora kadhi rekudzikisira chemishonga
Zvakajairika mhedzisiro mhedzisiro yeAmitiza vs. Linzess
Amitiza naLinzess vane zviitiko zvakajairika zvakashata pakati pavo, asi zvakare zvimwe zvakasarudzika kune mumwe nemumwe mushonga. Dhairrhea ndicho chikonzero chakajairika chekurapa kuregedza kwemishonga iyi, uye inowanzoitika mhedzisiro kune ese ari maviri madhiragi.
Amitiza inonyanya kukonzera kushungurudza, kunoitika mune angangoita mumwe wevatatu varwere vanotora mushonga. Izvi zvinoita kunge zvinowanzoitika kazhinji kana zvikatorwa padumbu risina chinhu. Dzimwe nguva kusvotwa uku kwakanyanya uye kunopedza simba, kuchichengeta varwere kubva pane zvakajairika zviitiko zvezuva nezuva. Varwere paAmitiza vakashuma zviitiko zvakashata sedzungu, kuneta, uye kurwadziwa pachipfuva, nepo varwere veLinzess vasina kutaura izvi mhedzisiro.
Izvi hazviitirwe kuti zvive zvakazara rondedzero yemhedzisiro yakaipa, ndapota bvunza chiremba wako kana wemishonga kuti uwane yakazara runyorwa.
| Amitiza | Linzess | |||
| Side maitiro | Zvinoshanda? | Kakawanda | Zvinoshanda? | Kakawanda |
| Nausea | Ehe | 29% | Ehe | <2% |
| Manyoka | Ehe | 12% | Ehe | 16-20% |
| Kutemwa nemusoro | Ehe | gumi neimwe% | Ehe | 4% |
| Marwadzo emudumbu | Ehe | 8% | Ehe | 7% |
| Mimba yekudzivirira / kubvisa | Ehe | 6% | Ehe | 2-3% |
| Kubata ropa | Ehe | 6% | Ehe | 4-6% |
| Kusvipa | Ehe | 3% | Ehe | <2% |
| Edema | Ehe | 3% | Kwete | n / a |
| Kusuruvara kwepamuviri | Ehe | 3% | Kwete | n / a |
| Dzungu | Ehe | 3% | Kwete | n / a |
| Kurwadziwa pachifuva | Ehe | piri% | Kwete | n / a |
| Dyspnea | Ehe | piri% | Kwete | n / a |
| Dyspepsia | Ehe | piri% | Ehe | <2% |
| Kuneta | Ehe | piri% | Kwete | n / a |
| Muromo wakaoma | Ehe | 1% | Kwete | n / a |
Kunobva: Amitiza ( Zuva Nezuva Linzess ( Zuva Nezuva )
Kubatana kwezvinodhaka zveAmitiza vs. Linzess
Amitiza naLinzess vanofanirwa kushandiswa nekuchenjerera kune varwere pamishonga ine anticholinergic zvivakwa. Anticholinergic zvinodhaka zvinogona kukurudzira kuzvimbirwa uye kupokana nezviitwa zvepharmachemic zveAmitiza neLinzess.
Varwere vane loop diuretics, senge furosemide (Lasix), vanofanirwa kudzivirira Amitiza sezvo vangave vari mungozi yekurasikirwa ne potassium yakawandisa (hypokalemia). Mune ava varwere, Linzess inogona kunge iri sarudzo inosarudzwa.
Iri harisi runyorwa rwakakwana rwekupindirana kwezvinodhaka. Kune runyorwa ruzere, ndokumbirawo ubvunze zvekurapa kubva kuna wako gastroenterology healthcare nyanzvi.
| Zvinodhaka | Kirasi yemishonga | Amitiza | Linzess |
| Atropine Belladonna Benztropine Chlordiazepoxide Dicyclomine Flavoxate Glycopyrrolate Homatropine Hyoscyamine Methscopolamine Oxybutynin Scopolamine | Anticholinergics | Ehe | Ehe |
| Bismuth salicylate Loperamide | Antidiarrhea | Kwete | Ehe |
| Bumetanide Furosemide Torsemide | Loop diuretics | Ehe | Kwete |
| Lactulose | Laxative | Ehe | Kwete |
| Solifenacin | Antimuscarinic | Ehe | Kwete |
| Methadone | Opioid | Ehe | Kwete |
Yambiro yeAmitiza naLinzess
Amitiza inogona kukonzera kushushikana kwakanyanya. Iko kuitika kwekusvotwa kunogona kuderedzwa nekutora Amitiza nechikafu.
Amitiza neLinzess havafanirwe kupihwa varwere vari kuita manyoka zvakanyanya nekuti izvi zvinogona kukonzera kuti manyoka awedzere. Kana manyoka achitanga mushure mekunge watanga kurapwa, rega kurapwa, uye bata wako mupi wezvehutano.
Syncope, kana dzungu pakumira, pamwe neiyo hypotension, kana yakaderera BP, inogona kuitika mushure mekutanga kutanga Amitiza. Varwere vanofanirwa kuongorora yavo yeropa uye kusimuka zvishoma kubva panzvimbo yekugara kuti vadzivise kuwa. Zivisa chiremba wako nezve chero mamiriro ekurapa kana zvimwe zvinodhaka zvaunogona kutora izvo zvinogona kukuvadza syncope.
Dyspnea, kana kunzwa kwechipfuva kuomarara uye kupfupika kwemweya, zvinogona kuitika neAmitiza. Ichi chiratidzo chinowanzoisa mukati memaminitsi makumi matatu kusvika makumi matanhatu echirwere uye chinogona kutora kwemaawa akati wandei. Kana izvi zvikaitika, unofanirwa kubata chiremba wako.
Linzess anotakura yambiro yebhokisi uye chishamiso nezvekushandiswa kwevarwere vevana nekuda kwekugona kwayo kukonzera kupera simba kwemvura. Mamwe ruzivo nezveyambiro iyi anogona kuwanikwa pa fda.gov .
Inowanzo bvunzwa mibvunzo nezve Amitiza vs. Linzess
Chii chinonzi Amitiza?
Amitiza mushonga wekunyorerwa unoshandiswa kurapa kusingaperi idiopathic kuvhiringidzwa uye mukurapa kweanoshungurudza ura chirwere nekuzvimbirwa. Amitiza inobvumidzwawo kurapa opioid-inokonzera kupatira kushandiswa kwechirwere chisingaperi, chisiri chegomarara. Inoshanda nekuwedzera hutumbu hwekuvanzika kuti ushandure kusagadzikana kwechigaro. Inowanikwa seyemuromo capsule mune 8 mcg uye 24 mcg simba.
Chii chinonzi Linzess?
Linzess mushonga wekunyorerwa unoratidzirwa pakurapwa kwechirwere chisingaperi chinonzi idiopathic constipation uye chinoshatisa ura hwechirwere nekuzvimbirwa. Inowedzera ura hwemukati uye zvemukati. Inowanikwa mumumuromo makapisi mumasimba e72 mcg, 145 mcg, uye 290 mcg.
Amitiza naLinzess vakafanana here?
Ipo Amitiza naLinzess mumwe nemumwe achirapa kupatira, ivo havana kufanana. Amitiza ndeye bicyclic fatty acid uye prostaglandin E1 (PGE 1) inogadzirwa, uye inoiswa mukati kaviri pazuva. Linzess ndeyekirasi yeguanylate cyclase C (GC-C) agonists, uye inoiswa kamwe chete zuva nezuva.
Amitiza kana Linzess zvirinani here?
Amitiza naLinzess vakaratidza kushanda kwakadaro mukubvisa kuzvimbirwa. Vanyori vanogona kutarisa zvinhu zvakaita sekumisikidza marodhi uye zviitiko zvakashata kana uchisarudza kuti ndeupi mushonga wakanakira murwere. Amitiza naLinzess vanosarudzwa mukusungwa kusingaperi nekuti mamwe marapirwo echinyakare akadai setool softeners (eg docusate), osmotic laxatives (semuenzaniso Miralax), kana laxatives inosimudzira (semuenzaniso senna) inogona kukonzera kusanzwisisika kwakanyanya kwe electrolyte uye kusimudzira kushivirira nekushandisa kwenguva refu.
Ndinogona here kushandisa Amitiza kana Linzess ndiine nhumbu?
Njodzi dzinosanganisirwa nemishonga yekushandisa Amitiza kana Linzess hadzina kutariswa nekuti hapana yakakwana, inodzorwa kiriniki miedzo kuratidza kwavo kuchengetedzeka. Iko kushandiswa kwemishonga iyi mukuzvitakura kunofanirwa kungogumira kumamiriro ezvinhu apo mabhenefiti ari pachena kupfuura njodzi.
Ndinogona here kushandisa Amitiza kana Linzess nedoro?
Iko hakuna zvinopesana zvakanangana nekutora iyi mishonga uye kunwa doro, zvisinei, zvakakosha kuti uzive kuti doro rinogona kutungamira mukushaya mvura uye nemanyoka, sezvingaite izvi zvinodhaka, zvichiisa varwere panjodzi yekushomeka zvakanyanya.
Amitiza inokonzera kuwedzera uremu here?
Amitiza haina kuratidzwa kuti inokonzera kurema.
Zvinotora nguva yakareba sei kuti Linzess ashande?
Ruyamuro rwekusungwa kazhinji runowanzoitika mukati mevhiki imwe chete kana mbiri, pamwe nekuenderera mberi kwekuvandudzwa kwezviratidzo zvinoitika kusvika kumavhiki gumi nemaviri.
Ndiani asingafanire kutora Amitiza?
Varwere vane chipingaidzo mumakanika avo emudumbu (GI) turakiti havafanirwe kutora Amitiza. Zvakare, varwere vari kusangana nemanyoka ane mwero kusvika kwakanyanya havafanirwe kutora Amitiza. Vakadzi vane nhumbu kana kuyamwisa, pamwe nevarwere vevana, vanofanirwa kudzivirira Amitiza.
