Phenylephrine vs. pseudoephedrine: Misiyano, kufanana, uye izvo zviri nani kwauri
Zvinodhaka Vs. ShamwariKuongorora kwemishonga & misiyano mikuru | Conditions kurapwa | Kubudirira | Inishuwarenzi kufukidza uye mutengo kuenzanisa | Zvimwe zvinokanganisa | Kubatana kwezvinodhaka | Yambiro | MIBVUNZO
Kune zvinhu zvakawanda zvinopa kukonzeresa mumhino uye sinus kumanikidza, kunyanya mwaka wegoregic rhinitis uye yakajairwa kutonhora. Kumanikidza uye sinus kumanikidza kunogona kukanganisa kufema kwemhino, kunotungamira kumusoro, uye kudzikisa kugadzirwa. Phenylephrine (Sudafed PE) uye pseudoephedrine (Sudafed) ndiwo marudzi maviri ezvekudzvinyirira anogona kuve anoshanda mukuderedza sinus kumanikidza. Iyi mishonga inoshanda nekumisikidza yakananga adrenergic receptors mumhino yekumhino, pamwe nezvimwe zvikamu zvemuviri. Kunyangwe iwo akafanana mune dzimwe nzira, pane mamwe misiyano yakakosha inogona kuona kuti ndeipi iri decongestant yakakodzera kwauri.
Ndeupi mutsauko mukuru pakati pe phenylephrine uye pseudoephedrine?
Phenylephrine (Chii chinonzi Phenylephrine?) Mushonga wekumanikidza unowanikwa wega kana mumhando dzakasiyana dzemusanganiswa wechando uye nefuru zvigadzirwa. Inowanikwa pamusoro pe-the-counter (OTC), uye haidi mushonga kana kutemerwa kwemashoko ekutenga. Phenylephrine ndeyeakasimba alpha-adrenergic agonist uye haina kana beta-adrenergic agonist chiitiko. Alpha-adrenergic receptors, kana ichisimudzirwa, inoitisa kukanganiswa kwemitsipa yeropa. Beta-adrenergic receptors, kana yakasimudzirwa, inoitisa kuzorora kwemitsipa yeropa, uye zvakare inokonzeresa kuwanda kwemoyo. Ipo ichikonzeresa imwe vasoconstriction munzira yemumhuno iyo inogona kudzikamisa sinus kumanikidza, inokonzeresa vasoconstriction mumuviri wese iyo inogona kuwedzera kuwedzera kweropa. Phenylephrine inowanikwa mukugadzirira kwemuromo sehwendefa kana mvura, pamwe nemhinduro inopinza. Iyo jekiseni mhinduro yaizongogadziriswa mune yehutano mamiriro.
Pseudoephedrine (Chii chinonzi Pseudoephedrine?) Mushonga wekudzikisa mhino uyo unowanikwawo wega kana mumhando dzakasiyana dzemishonga inotonhora uye yechirwere. Inowanikwa pasina mushonga, asi kutenga kwayo kunogumira pamadhigirii akasiyana. Nyika yega yega, pamwe chete nenhungamiro yemubatanidzwa, inosarudza miganho yekutenga kune vatengi vayo Kutengwa kwepseudoephedrine kunofanirwa kuitika kukambani yemishonga neyemufesi aripo uye kwakapinda mune dhatabhesi. Izvi zvinorambidzwa zvavepo nekuti pseudoephedrine chinhu chakakosha mukugadzira zvisiri pamutemo kwemethamphetamine.
Pseudoephedrine inomutsa alpha-adrenergic receptors mumhino mucosa, pamwe ne beta-adrenergic receptors mumuviri wese. Izvi zvinotungamira mukushushikana kwemhino uye bronchial kuzorora, asiwo zvinotungamira mukuwedzera kwemoyo uye contractility. Inowanikwa mukugadzirira kwemuromo sehwendefa kana mvura, pamwe nemhinduro inopinza. Iyo jekiseni mhinduro yaizongogadziriswa mune yehutano mamiriro.
| Misiyano mikuru pakati pe phenylephrine uye pseudoephedrine | ||
|---|---|---|
| Phenylephrine | Pseudoephedrine | |
| Kirasi yemishonga | Alpha-adrenergic agonist | Alpha-adrenergic uye beta-adrenergic agonist |
| Brand / generic chinzvimbo | Inowanikwa brand uye generic | Inowanikwa brand uye generic |
| Chii chinonzi zita rechiratidzo? | Yakasungwa PE | Kushamiswa |
| Ndeapi mafomu (s) ayo mushonga unouya? | Piritsi-rekusunungura piritsi, yemuromo mvura | Yekukurumidza-kuburitsa piritsi, yakawedzerwa-kuburitsa piritsi, yemuromo mvura |
| Ndeipi muyero wakajairwa? | 10 mg maawa mana ese | 60 mg maawa mana kusvika matanhatu ega ega |
| Yakareba sei iyo yekurapa? | Ipfupi nguva kusvikira zororo rechiratidzo | Ipfupi nguva kusvikira zororo rechiratidzo |
| Ndiani anowanzoshandisa mushonga? | Vana vane makore gumi nemaviri zvichikwira, vakuru | Vana vane makore mana zvichikwira, vakuru |
Mamiriro ezvinhu anorapwa ne phenylephrine vs. pseudoephedrine
Iko kune jekiseni fomu ye phenylephrine inobvumidzwa kurapa hypotension, kana yakadzika kwazvo BP, mune mamiriro ane chekuita nekuvhunduka kana kutindivadza. Iyi dosing inowanzo kupihwa sejekiseni munzvimbo yekutarisira hutano uko murwere ari kuongororwa nachiremba nevamwe vatapi vezvehutano. Inoshandiswa zvakare off-label, isina FDA mvumo, kurapa ischemic priapism (kumisikidzwa muvanhurume kwakagara kwenguva refu). Iyo yeku-the-kavha dhizaini fomu ye phenylephrine inoshandiswa seyemumhino yekudzivirira.
Pseudoephedrine inobvumidzwa kurapa kuzara kwemhuno.
| Mamiriro | Phenylephrine | Pseudoephedrine |
| Hypotension | Ehe | Kwete |
| Ischemic priapism | Kunze-chitaridzi | Kwete |
| Kuzara kwemhino | Ehe | Ehe |
Phenylephrine kana pseudoephedrine inoshanda here?
Pane imwe nguva, pseudoephedrine yaingova yega yekudzora mumhino pamusika. Zvisinei, apo kutengesa kwechigadzirwa kwakatanga kudziviswa, vagadziri vakatarisa kugadzirisa zvigadzirwa zvavo nechimwe chinhu chinoshanda kuitira kuti vagare pamashefu ezvitoro uye atenge nyore. Phenylephrine yakabva yaita yekushambadza yemumuromo inowanikwa mune zvigadzirwa zvinogona kutengwa pasina kuenda kukamba yemishonga kuti kutenga kwako kuteme nemushambadzi.
Kuwedzera kushandiswa kwe phenylephrine kwakakurudzira vaongorori kuti vaongorore kana mhedzisiro yadzo yakanyanya kuita seya pseudoephedrine. Mune yakasarudzika, inodzorwa-placebo kudzidza , varwere vane mwaka allergic rhinitis vakafumurwa nehuswa mukume muVienna Dambudziko Chamber. Vakagashira phenylephrine, pseudoephedrine, kana placebo kudzikisira zviratidzo zvavo. Chidzidzo chacho chakagumisa kuti pakanga pasina musiyano wakakura pakati pe phenylephrine uye placebo. Nekudaro, pseudoephedrine yakapa musiyano wakakura mukudzora kwemazino kana ichienzaniswa neese placebo uye phenylephrine. Mhedzisiro iyi inoratidza kuti pseudoephedrine ndiyo yakasarudzika yemhino yekudzivirira.
Vamwe vaongorori vakaita akaratidza kunetsekana kuti shuviro yedu yekudzora kugadzirwa kwemethamphetamine nekumisa kutengesa kwepseudoephedrine kwakatungamira kune chakaderera chigadzirwa (phenylephrine) chiri kushandiswa zvakanyanya munzvimbo yayo.
Nguva zhinji, kurapwa kwehinhinitis uye sinus kumanikidza kunogona kushanda zvakanyanya kana vamwe vamiririri vakashandiswa musanganiswa. Antihistamines, semuenzaniso, inononoka kugadzirwa kwemamousu uye inogona kuwedzera mhedzisiro yemumhino yekudzivirira.
Kuvhavha uye mutengo kuenzanisa kwe phenylephrine vs. pseudoephedrine
Phenylephrine mumuromo wayo, pamusoro-iyo-fomu fomu haidi mushonga. Izvo hazviwanzo kuvharwa neMedare kana zvimwe zvirongwa zveinishuwarenzi zvekutengesa. Ivhareji yemutengo weSudafed PE iri kutenderera $ 6- $ 8 kana ichitengwa pamusoro-pe-iyo, asi kana chiremba wako achinyora tsamba, unogona kuzadza ku pharmacy yakaderera se $ 5.96 nekoponi kubva kuSingleCare.
Pseudoephedrine, kunyangwe ichirambidzwa kutenga kuchitoro chemishonga, iri zvakare mushonga weOTC. Kana chiremba wako achinyora tsamba yepseudoephedrine, iwe unozokwanisa kuwana huwandu hwavanoraira kunyangwe hazvo hwakakwirira kupfuura iyo nyika muganho wekutenga-pamusoro-kwe-counter.
Pseudoephedrine haiwanzo kuvharwa neMedare kana zvimwe zvirongwa zveinishuwarenzi zvekushambadzira, asi mashoma anosarudzwa anogona kunge akanyorwa mushonga. Ivhareji mutengo wemapiritsi makumi maviri nemasere eSudafed 30 mg masekonzi kubva pamadhora 6- $ 10 kana uchitengwa pamusoro-pekutengesa Kana chiremba wako achinyora tsamba, unogona kuzadza generic kukhemisi kune yakaderera kunge $ 2.53 nekoponi kubva kuSingleCare .
| Phenylephrine | Pseudoephedrine | |
| Kazhinji yakafukidzwa neinishuwarenzi? | Kwete | Kwete |
| Inowanzo kufukidzwa neMedare? | Kwete | Kwete |
| Standard muyero | 18, 10 mg mahwendefa | 24, 30 mg mahwendefa |
| Chaizvoizvo Medicare copay | n / a | n / a |
| SingleCare mutengo | $ 6 + | $ 2- $ 5 |
Tora kadhi reSpecialCare rekutora kadhi
Zvakajairika mhedzisiro mhedzisiro ye phenylephrine vs. pseudoephedrine
Phenylephrine uye pseudoephedrine ese ari maviri adrenergic agonists uye ane mamwe akafanana mhedzisiro mhedzisiro, asi mutsauko wavo mukubatana kwealpha- uye beta-adrenergic receptors ndivo vane basa reimwe misiyano.
Phenylephrine uye pseudoephedrine zvinozivikanwa kukonzera kusagadzikana, dzungu, kurwadziwa nemusoro, kushaya hope, kutya, uye kusagadzikana. Uye zvakare, pseudoephedrine yakanyorwa kuti inokonzeresa tachycardia, palpitations, arrhythmia, kuona kwakashata, uye anorexia. Izvo zvakaoma kutsanangura kuti kazhinji sei mhedzisiro iyi inogona kuitika.
Varwere vane yakakwira BP kana zvimwe zvinozivikanwa zvemoyo mamiriro havafanirwe kushandisa pseudoephedrine pasina nhungamiro kubva kuna chiremba wavo.
Iyi tafura inotevera haina kuitirwa kuti ive izere rondedzero yemhedzisiro. Iwe unofanirwa kubvunza kuna wemishonga kana mumwe wehutano wezvehutano kuti uwane yakazara runyorwa.
| Phenylephrine | Pseudoephedrine | |||
| Side Migumisiro | Zvinoshanda? | Kakawanda | Zvinoshanda? | Kakawanda |
| Kufunganya | Ehe | Hazvina kutsanangurwa | Ehe | Hazvina kutsanangurwa |
| Dzungu | Ehe | Hazvina kutsanangurwa | Ehe | Hazvina kutsanangurwa |
| Kutemwa nemusoro | Ehe | Hazvina kutsanangurwa | Ehe | Hazvina kutsanangurwa |
| Kusarara | Ehe | Hazvina kutsanangurwa | Ehe | Hazvina kutsanangurwa |
| Kutya | Ehe | Hazvina kutsanangurwa | Ehe | Hazvina kutsanangurwa |
| Kusadzikama | Ehe | Hazvina kutsanangurwa | Ehe | Hazvina kutsanangurwa |
| Tachycardia | Kwete | Hazvina kutsanangurwa | Ehe | Hazvina kutsanangurwa |
| Palpitations | Kwete | Hazvina kutsanangurwa | Ehe | Hazvina kutsanangurwa |
| Cardiac arrhythmias | Kwete | Hazvina kutsanangurwa | Ehe | Hazvina kutsanangurwa |
| Kuona kwakashata | Kwete | Hazvina kutsanangurwa | Ehe | Hazvina kutsanangurwa |
| Anorexy | Kwete | Hazvina kutsanangurwa | Ehe | Hazvina kutsanangurwa |
Kunobva: Zuva Nezuva (phenylephrine) Zuva Nezuva (pseudoephedrine)
Kubatana kwezvinodhaka zve phenylephrine vs. pseudoephedrine
Phenylephrine uye pseudoephedrine vane yakafanana chaizvo yekudyidzana zvinodhaka nekuda kwavo adrenergic mhedzisiro pane alpha uye beta receptors. Alpha-blockers, senge tamsulosin, inogona kudzikisira iyo vasoconstrictive zvivakwa zvemaviri decongestants zvichivaita zvisashande.
MAO inhibitors, senge selegiline, uye ergot zvigadzirwa, senge bromocriptine, inogona kusimudzira huwandu hwehutachiona hwemhedzisiro. Izvi zvingave zvine chekuita mune mumwe munhu ane pre-iripo hypertension uyo angave achifunga nezvekushandisa zvakanyanya. Iko kusanganiswa kwe phenylephrine kana pseudoephedrine ine MAO inhibitors kana ergot zvigadzirwa zvinopesana.
Iyi inotevera rondedzero haina kuitirwa kuti ive izere runyorwa rweese angangoita kusangana kwemishonga. Ndokumbirawo ubvunze wemishonga wako kana chiremba kuti uwane yakazara runyorwa uye rumwe ruzivo.
| Zvinodhaka | Kirasi Yezvinodhaka | Phenylephrine | Pseudoephedrine |
| Alfuzosin Doxazosin Terazosin Tamsulosin | Alpha-1 vanovharira | Ehe | Ehe |
| Carvedilol Labetalol Nadolol | Beta anovharira | Ehe | Ehe |
| Selegiline Phenelzine | MAO Inhibitors | Ehe | Ehe |
| Ergotamine Bromocriptine | Ergot alkaloids | Ehe | Ehe |
| Methyldopa Reserpine | Antihypertensives | Ehe | Ehe |
| Atomoxetine | Kusarudza norepinephrine reuptake inhibitors | Ehe | Ehe |
| Amitriptyline Clomipramine Doxepin Nortriptyline | Tricyclic antidepressants | Ehe | Ehe |
Yambiro dze phenylephrine vs. pseudoephedrine
Phenylephrine uye pseudoephedrine zviripo pasina mushonga uye zvinowanzoonekwa semishonga yakachengeteka. Nekuda kwemhedzisiro yavo pamwoyo, varwere vane yakakwira BP uye chirwere chemwoyo havafanirwe kushandisa madhiragi aya vasina mvumo yakajeka kubva kuna chiremba wavo. Iyi mishonga inoitirwa kushandiswa kwenguva pfupi kwekuzorora kweacute rhinitis uye sinus kumanikidza. Varwere vanoona zviratidzo izvi kwenguva yakareba kupfuura mazuva manomwe, kana avo vanokura fivhiri, vanofanirwa kubvunza chiremba.
Phenylephrine iri mukati nhumbu nhumbu C zvinoreva kuti zvidzidzo mumhuka zvakaratidza migumisiro yakaipa kumucheche. Kana mushonga uri muchikamu C, panogona kunge paine mamwe mamiriro ezvinhu apo bhenefiti kumurwere ane nhumbu inopfuura njodzi, uye phenylephrine haifanire kushandiswa pasina mvumo kubva kuna chiremba wako. Pseudoephedrine kubata pamuviri chikamu B zvinoreva kuti zvidzidzo zvemhuka hazvina kuratidza migumisiro yakaipa kumucheche. Pseudoephedrine inoonekwa seyakachengeteka kutora kana uine pamuviri mushure mekubvunza chiremba wako. Pseudoephedrine inofanirwa, zvisinei, kudzivirirwa mune yekutanga trimester.
Inowanzo bvunzwa mibvunzo nezve phenylephrine uye pseudoephedrine
Chii chinonzi phenylephrine?
Phenylephrine is over-the-counter nasal decongestant inowanikwa mu5 mg uye 10 mg mapiritsi, pamwe nemhinduro yemuromo. Inowanikwawo mune jekiseni fomu iyo inongoshandiswa chete munzvimbo yevanorwara nevezvokurapa kune yakaderera BP. Phenylephrine inogona kutengwa pasina kurambidzwa kana kutemerwa kweruzivo rwemutengi.
Chii chinonzi pseudoephedrine?
Pseudoephedrine is over-the-counter nasal decongestant inowanikwa mu 30 mg uye 60 mg mapiritsi, pamwe ne120 mg uye 240 mg akawedzeredzwa-mapiritsi mapiritsi. Inowanikwawo semhinduro yemuromo. Pseudoephedrine kutenga kunofanirwa kuitirwa kukhemisi uye ruzivo rwekutenga runofanira kuiswa mudhatabhesi. Miganhu yekutenga inoiswa nehurumende uye nemitemo yenyika.
Phenylephrine kana pseudoephedrine zvakafanana here?
Phenylephrine uye pseudoephedrine ese ari maviri adrenergic agonists. Phenylephrine ine hushamwari kune chete alpha-adrenergic receptors, nepo pseudoephedrine ine hukama kune ese maalpha- uye beta-adrenergic receptors. Iwo mativi mhedzisiro maficha akafanana chaizvo.
Phenylephrine kana pseudoephedrine iri nani here?
Zvidzidzo zvakaratidza kuti pseudoephedrine inonyanya kushanda decongestant pane phenylephrine. Phenylephrine's decongestant mhedzisiro inogona kunge isina kunyanya kusiyana neiyo ye placebo. Mhedzisiro yemidziyo miviri inogona kuwedzerwa pamwe nekushandisa kwakafanana kwezvimwe zvigadzirwa zvinokanganisa rhinitis, senge antihistamines.
Ndinogona here kushandisa phenylephrine kana pseudoephedrine ndiine nhumbu?
Phenylephrine haifanire kushandiswa kana uine pamuviri kunze kwekunge rubatsiro kuna amai ruchikurira njodzi. Pseudoephedrine inoonekwa seyakachengeteka kutora mushure mekutanga kwetatu. Nguva dzose bvunza chiremba wako usati watora mushonga wemhino kana uine pamuviri.
Ndinogona here kushandisa phenylephrine kana pseudoephedrine nedoro?
Phenylephrine uye pseudoephedrine dzakachengeteka kutora kana uchinwa doro.
Phenylephrine inokurudzira here?
Phenylephrine inokurudzira alpha-adrenergic receptors iyo inogona kuita kuti ive inokonzeresa epakati tsinga system inosimudzira mhedzisiro sekuzorora, kushushikana, uye kushaya hope. Izvo zvinofungidzirwa kuti zvinogona kusakonzeresa mhedzisiro kune iyo pseudoephedrine inoita, zvakadaro.
Ndiani asingafanire kutora phenylephrine?
Varwere vane BP yakakwira, pre-iripo chirwere chemoyo, kana mamwe mamiriro emwoyo havafanirwe kutora phenylephrine vasina mvumo kubva kuna chiremba wavo. Kune dzimwe nzira dzekudzivirira dzakasarudzika, senge mapfumo emumhino, ayo angave akakodzera mune ino huwandu. Vakadzi vane nhumbu vanofanirwa kubvunza chiremba vasati vashandisa phenylephrine.
Phenylephrine yakanaka decongestant here?
Zvidzidzo zvakaratidza kuti phenylephrine yakaderera, kana isinganyatso shanda, inodzvinyirira kupfuura pseudoephedrine. Muchokwadi, zvinogona kusapa chero bhenefiti pamusoro peiyo ye placebo.
