Jardiance vs. Invokana: Misiyano, kufanana, uye izvo zviri nani kwauri
Zvinodhaka Vs. ShamwariKuongorora kwemishonga & misiyano mikuru | Conditions kurapwa | Kubudirira | Inishuwarenzi kufukidza uye mutengo kuenzanisa | Zvimwe zvinokanganisa | Kubatana kwezvinodhaka | Yambiro | MIBVUNZO
Kana iwe uine rudzi rwechipiri chirwere cheshuga, chiremba wako anogona kukurudzira imwe yemishonga yeshuga inonzi Jardiance kana Invokana. Jardiance (yakaitwa naBoehringer-Ingelheim) uye Invokana (yakaitwa naJanssen Pharmaceuticals) mazita maviri ezvinodhaka zvinodhaka zvinoratidzirwa kurapwa kwerudzi rwechipiri chirwere cheshuga. Ivo ndevekirasi yemishonga inonzi SGLT2 (sodium-glucose cotransporter-2) inhibitors. Ivo vanoshanda nekubatsira itsvo kubvisa shuga yeropa kuburikidza neweti, nokudaro vachideredza shuga yeropa.
Ndeupi mutsauko mukuru pakati peJardiance vs.Vhokana?
| Misiyano mikuru pakati peJardiance neInvokana | ||
|---|---|---|
| Jardiance | Invokana | |
| Kirasi yemishonga | SGLT2 inhibitor | SGLT2 inhibitor |
| Brand / generic chinzvimbo | Brand | Brand |
| Chii chinonzi generic zita? | Empagliflozin (haisati yawanikwa mune generic fomu) | Kanagliflozin (haisati yawanikwa mune generic fomu) |
| Ndeapi mafomu (s) ayo mushonga unouya? | Hwendefa: 10 mg, 25 mg (empagliflozin inowanikwawo ne metformin mune yakasanganiswa zita-zita mushonga unonzi Synjardy, uye neinagliptin muGlyxambi) | Hwendefa: 100 mg, 300 mg (canagliflozin inowanikwawo ne metformin mune yakasanganiswa zita-zita mushonga unonzi Invokamet) |
| Ndeipi muyero wakajairwa? | 10 mg mangwanani oga oga; inogona kuwedzera kusvika ku25 mg mangwanani ega ega | 100 mg mangwanani oga oga; inogona kuwedzera kusvika ku 300 mg mangwanani ega ega |
| Yakareba sei iyo yekurapa? | Zvinosiyana | Zvinosiyana |
| Ndiani anowanzoshandisa mushonga? | Vakuru vane mhando 2 chirwere cheshuga mellitus | Vakuru vane mhando 2 chirwere cheshuga mellitus |
Unoda akanakisa mutengo paJardiance?
Saina kuti Jardiance mutengo chenjedzo uye uwane kuti kana mutengo wachinja!
Wana machenjedzo emitengo
Mamiriro ezvinhu anorapwa neJardiance vs. Invokana
Jardiance (Chii chinonzi Jardiance?) Inoshandiswa, pamwe nekudya uye kurovedza muviri, kugadzirisa shuga yeropa muvanhu vakuru vane chirwere cheshuga cheshuga, uye kudzikisa njodzi yekufa kwemoyo (CV) muvanhu vakuru vane chirwere cheshuga cheshuga uye yakasimbiswa CV chirwere .
Invokana inoshandiswa zvakare, mukuwedzera pakudya uye kurovedza muviri, kusimudzira kudzora shuga muropa muvanhu vakuru vane chirwere cheshuga chechipiri. Iyo zvakare inoshandiswa kudzikisa njodzi yezviitiko zvikuru zveCV mune vanhu vakuru vane mhando 2 chirwere cheshuga mellitus uye yakasimbisa chirwere chemoyo. Chiratidzo chechitatu kudzikisa njodzi yekupera-padanho chirwere cheitsvo, kupetwa kaviri kweserum creatinine, kufa kweCV, nekuchengetwa muchipatara kwekutadza kwemoyo kune vanhu vakuru vane chirwere cheshuga cheshuga uye chirwere cheshuga nephropathy nealbuminuria.
Hapana mushonga unofanirwa kushandiswa kurapa rudzi rwekutanga chirwere cheshuga kana chirwere cheshuga ketoacidosis.
| Mamiriro | Jardiance | Invokana |
| Batanidza kune kudya uye kurovedza muviri kuvandudza glycemic kutonga mune vakuru vane mhando 2 chirwere cheshuga mellitus | Ehe | Ehe |
| Deredza njodzi yekufa kwemoyo muvanhu vakuru vane rudzi rwechipiri chirwere cheshuga uye yakasimbisa chirwere chemoyo | Ehe | Kwete |
| Deredza njodzi yezviitiko zvakakomba zvemoyo muvanhu vakuru vane chirwere cheshuga mellitus uye yakasimbisa chirwere chemoyo. | Kwete | Ehe |
| Deredza dambudziko rekupera-padanho chirwere cheitsvo, kupetwa kaviri kweserum creatinine, kufa kwemoyo, uye kuchipatara kwekutadza kwemoyo kune vanhu vakuru vane chirwere cheshuga mellitus uye chirwere cheshuga nephropathy nealbuminuria | Kwete | Ehe |
Jardiance kana Invokana inoshanda here?
Mune yakapofomara-bofu, inodzorwa ne placebo, 24-vhiki kudzidza yeJardiance se monotherapy (yakashandiswa yega) muna 986 mhando 2 varwere vechirwere cheshuga, kurapwa neJardiance kwakakonzera kudzikira kweHbA1c mazinga (chiyero cheglucose kudzora mumwedzi mishoma yapfuura), kudzikira kwekutsanya plasma glucose, uye huremu hwakaderera. Mukubatana nemamwe madhiragi eshuga kana ne insulin, Jardiance yaive nemhedzisiro yakafanana yekuvandudza nhamba dzakadai seHbA1c.
Mune yakapofomara-bofu, inodzorwa ne placebo, 26-vhiki kudzidza yeInvokana senge monotherapy (yakashandiswa yega) mu584 mhando 2 varwere vechirwere cheshuga, kurapwa neInvokana kwakadzikira huwandu hweHbA1c, kutsanya kwakaderera uye postprandial (mushure mekudya) glucose, huremu hwakaderera, uye pasi systolic BP. SaJardiance, kana yaidzidziswa pamwe chete nemamwe madhiragi eshuga kana ne insulin, Invokana yaivewo nemhedzisiro yakafanana yekuvandudza nhamba dzakadai seHbA1c
Mushonga unoshanda zvakanyanya unofanirwa kusarudzwa nachiremba wako, uyo anogona kutarisa pamufananidzo uzere wehutano hwako (s), nhoroondo, uye mimwe mishonga yauri kutora.
Tora kadhi rekudzikisira chemishonga
Kuvhavha uye mutengo kuenzanisa kweJardiance vs. Invokana
Pasina inishuwarenzi, Jardiance inodhura angangoita madhora mazana matanhatu nemakumi maviri neshanu uye Invokana inodhura madhora mazana matanhatu pazuva remakumi matatu. Jardiance inogona kunge iri mukana wekufukidzirwa neinishuwarenzi kupfuura Invokana; zvisinei, mitengo inosiyana zvakanyanya zvekuti zvakanaka kutarisa nekambani yeinishuwarenzi kana chirongwa cheMedicare Chikamu D kuti uwane rumwe ruzivo. Unogona kusevha mari neSingleCare paJardiance - uchiwana mushonga wekunyorerwa $ 434- $ 500- uye Invokana, uchibhadhara avhareji yemadhora mazana mana pamakumi matatu, mapiritsi e300mg.
| Jardiance | Invokana | |
| Kazhinji yakafukidzwa neinishuwarenzi? | Ehe | Zvinosiyana nechirongwa |
| Inowanzo kufukidzwa neMedare Chikamu D? | Ehe | Zvinosiyana nechirongwa |
| Standard muyero | # 30, 25 mg mahwendefa | # 30, 300 mg mahwendefa |
| Chaizvoizvo Medicare copay | $ 19-612 | $ 25- $ 568 |
| SingleCare mutengo | $ 434- $ 500 | $ 450 |
Mativi mhedzisiro yeJardiance vs. Invokana
Navo vaviri Jardiance uye Invokana, mhedzisiro inowanzoitika ndeye genital mycotic hutachiona, inoitika mune vese varume nevakadzi, asi kazhinji mune vakadzi. Urinary turakiti hutachiona zvakare yakajairwa mhedzisiro mhedzisiro yezvose zvinodhaka. Zvimwe zvakajairika mhedzisiro mhedzisiro yemishonga iyi inosanganisira nyota, kuwedzera weti, uye kuda kurutsa.
| Jardiance | Invokana | |||
| Side maitiro | Zvinoshanda? | Kakawanda | Zvinoshanda? | Kakawanda |
| DWS | Ehe | 7.6-9.3% * | Ehe | 4.4-5.9% * |
| Chirwere chepamuviri hutachiona | Ehe | Mukadzi: 5.4-6.4% Murume: 1.6-3.1% | Ehe | Mukadzi: 10.6-11.6% Murume: 3.8-4.2% |
| Utachiona hwepamusoro hwekufema | Ehe | 3.1-4% | Kwete | - |
| Nyota | Ehe | 1.5-1.7% | Ehe | 2.4-2.8% |
| Kuwedzera weti | Ehe | 3.2-3.4% | Ehe | 4.6-5.1% |
| Nausea | Ehe | 1.1-2.3% | Ehe | 2.1-2.3% |
* Marange nekuda kwekusiyana kwakasiyana. Kunobva: Mazuva eseMed (Jardiance ), Zuva Nezuva (Invokana)
Kubatana kwezvinodhaka kweJardiance vs. Invokana
Invokana inopindirana nemoyo chinodhaka Lanoxin (digoxin) nemishonga inova iyo UGT inducers (mishonga inogadziriswa nemamwe maenzimu) anosanganisira rifampin, phenytoin, phenobarbital, uye ritonavir.
Ose maviri Jardiance uye Invokana vanobatana ne diuretics senge Lasix (furosemide) uye hydrochlorothiazide, pamwe ne insulin uye mimwe mishonga yeshuga se metformin. Bvunza wako mupi wezvehutano nezvezvehutano.
| Zvinodhaka | Kirasi Yezvinodhaka | Jardiance | Invokana |
| Rifampin Phenytoin Phenobarbital Ritonavir | UGT inducers | Kwete | Ehe |
| Lanoxin (digoxin) | Cardiac glycosides | Kwete | Ehe |
| Lasix (furosemide) Hydrochlorothiazide | Diuretics | Ehe | Ehe |
| Glucophage (metformin) | Insulin chakavanzika | Ehe | Ehe |
Yambiro yeJardiance vs. Invokana
Nekuti vese vari vaviri Jardiance uye Invokana iSGLT2 inhibitors, vanogovana yakawanda yeyambiro yakafanana:
- Nekuda kwenjodzi yekuderera kweropa, BP inofanira kuongororwa. Shandisa zvakanyanya kungwarira mune varwere vanotora diuretics, varwere vakura, varwere vane itsvo kukanganisika, uye varwere vane yakaderera BP. Kushaya mvura mumuviri kunogona kuitika.
- Mishumo yeketoacidosis (yakanyanya shuga yeropa; acidic ketoni dzinovaka mumugini) zvakaitika kune varwere paSGLT2 inhibitors. Izvi zvinogona kuve zvakakomba, kana kutofa. Zviratidzo zvinogona kusanganisira nyota, kugara uchiita weti, kuda kurutsa, kurwadziwa mudumbu, kushaya simba, mweya unonhuwirira une muchero, uye kuvhiringidzika. Tsvaga kurapwa kwekukurumidzira, uye mushonga unofanirwa kumiswa. Varwere vari panjodzi yakanyanya ye ketoacidosis vanosanganisira kudzikisira insulin muyero, kudzikira kwekoriori nekuda kwekurwara kana kuvhiyiwa, kunwisa doro, uye chirwere chepancreatic.
- SGLT2 inhibitors inogona kukonzera matambudziko eitsvo . Chiremba wako anoongorora itsvo yako, uye otarisa zvinhu zvinowedzera njodzi yekukuvara kweitsvo, senge mishonga inowirirana uye mamwe marapirwo.
- Kune njodzi yakawedzera yehutachiona hwehutachiona (UTI) pamwe nehutachiona hutachiona hutachiona (vulvovaginal candidiasis mumadzimai; Candida balanitis muvarume, kazhinji vasina kudzingiswa).
- Kushandisa insulin kana imwe mishonga yeshuga inogona kuwedzera njodzi ye hypoglycemia (shuga shoma yeropa) uchitora SGLT2 inhibitor.
- Kana hypersensitivity ikaitika (zviratidzo zvechirwere chakadai sekuzvimba, kuvhara huro, nezvimwewo), mushonga unofanirwa kumiswa uye unofanirwa kutsvaga rubatsiro rwechimbichimbi.
- Kuwedzera kwehuwandu hweLDL cholesterol kunogona kuitika; cholesterol inofanira kuongororwa.
- Chakakomba, kutyisidzira hupenyu Chironda chaFenieni (necrotizing fasciitis yepineineum, chirwere chakakomba chehutachiona) chakataurwa. Varwere vanofanirwa kuongororwa nekukurumidza kana izvi zviratidzo zvikaitika: kurwadziwa, unyoro, kutsvuka, kana kuzvimba munzvimbo yekubereka kana yeperianal, fivha, kana malaise.
Invokana ine dzimwe yambiro.
- Kune yambiro yebhokisi inouya neInvokana, inova yambiro yakasimba sekudiwa neDFA (Kudya neDrug Administration), maererano nekudimburwa kwemaoko mudiki.
- Mumakiriniki ekuedzwa, paive nenjodzi yakawedzera yekudimburwa makumbo nemaoko muvarwere vanotora Invokana, mune varwere vane yakamisikidzwa chirwere cheCV kana vaive panjodzi yeCV chirwere. Akanyanya kudimburwa makumbo aive mugunwe nepakati petsoka, kunyangwe vamwe vaisanganisira makumbo. Vamwe varwere vaidimburwa makumbo kana kugurwa makumbo nemakumbo. Usati watanga Invokana, unofanirwa kutaura nachiremba wako nezve njodzi yako yekudimburwa. Kana iwe ukatora Invokana, unofanirwa kutariswa zvakanyanya kutapukirwa, kurwadziwa, unyoro, maronda, kana maronda mumakumbo ezasi, uye rega kutora Invokana uye utsvage kurapwa nekukasira kana izvi zvikaitika.
- Kune njodzi yakawedzera yekutyoka kwepfupa neInvokana.
Hapana Jardiance kana Invokana inokurudzirwa panguva yechipiri neyechitatu trimesters yepamuviri. Nekuda kwenjodzi yemhedzisiro yakakomba paitsvo dzemwana, hazvikurudzirwe kushandisa chero mushonga panguva yekuyamwisa.
Inowanzo bvunzwa mibvunzo nezve Jardiance vs. Invokana
Chii chinonzi Jardiance?
Jardiance, iyo ine mushonga empagliflozin, mushonga uri mukirasi yemishonga inozivikanwa seSGLT2 inhibitors, iyo inoshanda nekubatsira kubvisa shuga mumuviri kuburikidza neweti. Jardiance inogadzirwa naBoehringer-Ingelheim uye inotengeswa naBoehringer-Ingelheim naEli Lilly neKambani.
Chii chinonzi Invokana?
Invokana, iyo ine mushonga canagliflozin, iriwo mushonga mukirasi yemishonga inozivikanwa seSGLT2 inhibitors, iyo inoshanda nekubatsira kubvisa shuga mumuviri kuburikidza neweti.
Jardiance vs. Invokana yakafanana here?
Nekuti ivo vari mukirasi imwechete yemishonga, vane zvakawanda zvakafanana, asi mimwe misiyano yemhedzisiro, dhizaini, kudyidzana kwezvinodhaka, kunyeverwa, nezvimwe, zvakatsanangurwa pamusoro.
Jardiance vs. Invokana irinani?
Izvo zvinoenderana. Mishonga iyi miviri yakaratidza kuve inoshanda, sezvakakurukurwa pamusoro. Pakave pasina kuve nekuenzanisa kuenzanisa maviri emishonga musoro-kune-musoro. Chiremba wako anogona kukubatsira iwe kusarudza kana Jardiance kana Invokana yakakunakira iwe.
Ndinogona here kushandisa Jardiance vs.Vanaokana ndiri nepamuviri?
Hapana mushonga unokurudzirwa panguva yechipiri neyechitatu trimesters yepamuviri. Zvakare, hazvikurudzirwe kushandisa chero mushonga panguva yekuyamwisa nekuda kwenjodzi yemhedzisiro yakakomba kuitsvo dzemwana.
Kana iwe urikutotora Jardiance kana Invokana uye uone kuti une nhumbu, bata chiremba wako kuti akutungamire. Kudzora kweglucose panguva yekuzvitakura kwakakosha; zvisinei, zvinogona kuti chiremba wako achachinja mishonga yako kuti uwane glucose kudzora zvakachengeteka.
Ndinogona here kushandisa Jardiance vs. Invokana nedoro?
Doro ndechimwe chinhu chinogona kutungamira kune ketoacidosis. Taura nachiremba wako kana ukanwa doro usati watora Jardiance kana Invokana.
Ndeupi mushonga wakaenzana neInvokana?
Invokana ari mukirasi imwechete yemishonga asi haina kunyatsoenzana neJardiance, Farxiga (dapagliflozin), uye Steglatro (ertugliflozin).
Jardiance mushonga une njodzi here?
Mushonga wega wega unouya nenjodzi yemhedzisiro uye yambiro. Bvunza chiremba wako kuti uone kana Jardiance iri mishonga yakachengeteka uye yakakodzera kwauri.
Invokana iri kubviswa pamusika here?
Parizvino, Invokana ichiri pamusika. Iyo FDA yakaita muna 2017 maererano neyakawedzera njodzi yekudimburwa makumbo nemaoko kune varwere vane chirwere chemoyo chakasimba.
