Kuru >> Zvinodhaka Info >> Proton pump inhibitors (PPIs): Zvishandiso, zvakajairika zvigadzirwa, uye ruzivo rwekuchengetedza

Proton pump inhibitors (PPIs): Zvishandiso, zvakajairika zvigadzirwa, uye ruzivo rwekuchengetedza

Zvinodhaka Info Proton pombi inhibitors inogumira asidhi secretion mumuviri. Ivo anowanzo shandiswa kurapa chirungurira, indigestion, uye GERD.

Kana iwe wakambonzwa kusanzwisisika kwekutsva kwekunzwa kuchikwira kubva pachipfuva chako mushure mekudya, iwe ungangove wakamboona gastroesophageal reflux (GER), inozivikanwawo seacid reflux. Zvimwe zviratidzo zvaungangodaro wakanzwa kudzoreredzwa kweacidiki zvemukati mumuromo kana pahuro, kusvotwa, kurwadziwa pahuro, hoarseness, uye kuwedzera kugadzirwa kwemate. GER inoitika kamwechete mune imwe nguva kana dumbu rako mukati richiyerera richidzokera kumusoro kwako. Nekudaro, kana iko kunetseka kusagadzikana kukaitika nguva zhinji, saka unogona kunge uine gastroesophageal Reflux chirwere ( GERD ), iyo inorapwa nenzira dzakasiyana siyana.

Kazhinji, chiremba wako anotanga kukurudzira imwe shanduko yemararamiro ekuvandudza zviratidzo zvako. Kana izvo zvikasashanda, mupi wako anogona zvakare kukurudzira proton pump inhibitor (PPI). Iko kune matanhatu akasiyana maPPI, ese ane akafanana kushanda, saka kana iwe ukasapindura zvakanaka kune imwe, une akati wandei dzimwe sarudzo dzekuyedza. Enderera kuverenga kuti udzidze zvakawanda nezve akasiyana proton pombi inhibitors pamusika, mashandisiro avo, mazita ezita, uye ruzivo rwekuchengetedza.

Chinyorwa cheproton pombi inhibitors
Zita reBrand (zita regeneral)	Avhareji yemari mutengo	SingleCare kuchengetedza	Dzidza ZVIMWE
Prilosec (omeprazole) *	$ 338.83 pamakumi 30, 20 mg makapisi	Tora Prilosec coupons	Prilosec ruzivo
Nexium (esomeprazole) *	$ 275.09 pamakumi 30, 40 mg capsules	Tora Nexium coupons	Nexium ruzivo
Prevacid, SOLUTAB Prevacid (lansoprazole) *	$ 189.99 pa 30, 30 mg capsules	Tora Prevacid coupons	Prevacid ruzivo
Kunyengedza (dexlansoprazole)	$ 491.08 ye30, 30 MG capsules	Tora Dexilant coupons	Dhiyabhorosi mashoko
Protonix (pantoprazole)	$ 644.48 pamakumi matatu, 40 mg mahwendefa	Tora Protonix coupons	Zvinyorwa zveProtonix
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Zegerid (omeprazole + sodium bicarbonate) *	$ 3146.09 ye30, 20-1100 MG capsules	Tora Zegerid coupons	Zegerid ruzivo

* inowanikwa mune yekunyora uye OTC mafomu

Chii chinonzi proton pump inhibitors?

Proton pump inhibitors mishonga inozivikanwa inowanzoshandiswa kurapa GERD nematambudziko ayo, senge peptic solidure uye Barrett's esophagus. PPIs inoshandiswawo kurapa maronda ezvinhu zvakadai seHelicobacter pylori (H. pylori) hutachiona uye maronda anokonzerwa neasina-steroidal anti-anogumbura zvinodhaka (NSAIDs). Iyi kirasi yemishonga inoshandiswa zvakare kugadzirisa inorema acid kugadzirwa mune mamwe marudzi ematumbu matumbu. Dzimwe PPI dzinogona kuwanikwa pamusoro pe-iyo-counter, nepo dzimwe dzichida mushonga. Zvisinei, maproton pump inhibitors anoshandiswa zvakanyanya mishonga yemamiriro ane acid. Muchokwadi, nekuda kwekuwanda kwavo uye nekubudirira, proton pump inhibitors inowanzo shandiswa kwenguva yakareba kupfuura nzira yavo yekurapa. Kuti uone kuti uri kutora mushonga wako kwenguva chaiyo, ita shuwa yekukurukura izvi nachiremba wako kana mupi wezvehutano.

Ko proton pump inhibitors inoshanda sei?

Proton pump pump inhibitors inoshanda nekusunga nekumisikidza iyo H + / K + -ATPase, inova pombi inoona nezvekuviga acid mudumbu. Nekuti mamiriro akaita seGERD uye peptic ulcers ari akaomeswa nedumbu acid, ichivhiringidza huwandu hweacid secretion mumuviri wako haingogadzirise chete kuora moyo, indigestion, uye kurwadziwa kwepamuviri kwakabatana neGERD, asi zvakare inogona kubatsira kupodza iyo esophageal lining kana yakambobatwa. nekukwira kweasidhi.

Hupenyu mararamiro akachinjika senge kuonda (kana iwe uri kufuta kana kuti uchangobva kuwana uremu), kusimudza musoro wemubhedha, kudzivirira kudya kwakakora kwemafuta mukati memaawa maviri ekurara, uye kugara kure nezvikafu zvine acid uye zvinwiwa zvese zvinobatsira mukuderedza GERD. Wako mupi anogona zvakare kukurudzira antacids kana imwe kirasi yemishonga inonzi H2-blockers kubatsira kurapa GERD yako.

Chii chinonzi proton pump inhibitors inoshandiswa?

Zviratidzo zvinoenderana nemushonga chaiwo. Mienzaniso inosanganisira:

Kushungurudza
GERD
Dyspepsia (Indigestion)
Erosive uye isiri-erosive esophagitis
H. Pylori- maronda ane chekuita
NSAID-inosanganiswa nemaronda
Gastric uye duodenal maronda
Kudzivirirwa kwekudzokazve kwemaronda eronda
Asina-ulcer dyspepsia
Kudzivirira kwekushushikana-kwakabatana mucosal kubuda ropa
Gastrinomas
Zollinger-Ellison chirwere

Ndiani anogona kutora proton pump inhibitors?

Vakuru

Proton pump inhibitors kazhinji yakachengeteka uye inoshanda muvakuru varume nevakadzi. Nepo paine mimwe mhedzisiro yakaipa uye yambiro yekirasi iyi yemishonga, kushandisa yakaderera inodikanwa dosi uye isingapfuure iyo inokurudzirwa kureba kwerapi kunowanzo kuguma nemitengo yakaderera yemhedzisiro yakakomba.

Vacheche neVana

Proton pump inhibitors inogamuchirwa kuti ishandiswe muvana vane makore anopfuura 1-gore uye vanoiswa dosi zvichibva pahuremu. Kushandiswa kwePPIs muvana kunogona kukonzera njodzi yekuwedzera kwehutachiona senge pneumonia uye chirwere chemudumbu chinokonzerwa nehupenyu Zvakaoma . Proton pump inhibitors inogona zvakare kuwedzera njodzi yekutyoka muvana. Naizvozvo, iyi mishonga haiwanzo kupihwa kuvana kunze kwekunge watanga kubvunza kune wehutano mupi. Vacheche vane zviratidzo zveGERD vanogona kunyorerwa kumisikidzwa PPI kumiswa. Nekudaro, nekuti kushandiswa kweproton pump inhibitor muvacheche hakubvumidzwe neU.S.Food and Drug Administration (FDA), zviri kungwara kwemupi wako wekuchengeta hutano kusarudza izvo zvinodiwa.

Vakuru

Nekuti kushandiswa kwenguva refu kwePPIs kunogona kuwedzera njodzi yeC C. difficile hutachiona, kurasikirwa kwefupa, uye kutsemuka, izvo hazvikurudzirwi kwekushandisa kwenguva refu kune vakuru. Muchokwadi, iyo Beers Chinyorwa yemishonga ingangove isina kukodzera yevakuru vakuru inokurudzira kwete anopfuura masere masvondo ekuenderera mberi kwekushandisa muvakuru vanopfuura makore makumi matanhatu nemashanu.

Proton pump inhibitors yakachengeteka here?

Proton Pump Inhibitors Inoyeuka

Auromedics Pharma LLC: Yekuzvidira kurangarira pantoprazole 40mg yeJekiseni nekuda kwe Kuvapo kwegirazi inoramba iri mumudziyo , Zvita 2017

Proton pombi inhibitor kurambidzwa

Usatore proton pump inhibitors kana iwe uine nhoroondo yeiyo hypersensitivity reaction kune chero proton pump inhibitor.

Kunze kwe esomeprazole , proton pump inhibitors inofanirwa kudzivirirwa mune varwere vari kutorawo zvigadzirwa zvine rilpivirine.

Dzimwe yambiro dzinosanganisira:

Nekuda kweiyo acid kudzvanywa kweproton pump inhibitors, rebound acidity inogona kuitika mushure mekumisa kamwe kamwe iyi yemishonga. Kana iwe uri kuyedza kurega yako PPI, zvinokurudzirwa kudzikira pasi zvishoma nedhizaiti, kunyangwe mushure menguva pfupi yekurapa kwevhiki masere.
Muzviitiko zvisingawanzoitika, chirwere cheitsvo chinodzoserwa chakaonekwa kune varwere vanotora PPIs. Izvi zvinodaidzwa kuti tubulointerstitial nephritis uye zvinowanzo kuve nezviratidzo zvichibva pane zvinokonzeresa (fever, rash, kupfupika kwemweya) kune mamwe itsvo chaiwo maitiro (anorexia, malaise, kuda kurutsa). Kana zviratidzo izvi zvikaitika, proton pump inhibitor inofanirwa kumiswa uye rubatsiro rwekurapa runotsvaga nekukasira.
Kushandiswa kwenguva refu (makore maviri kana kupfuura) kunogona kukonzera kudzikira kwevhitamini B12 uye pakupedzisira, kushomeka kweB12. Sezvo B12 iri vhitamini yakakosha yemuviri, zvakakosha kuti utarise masosi kana kuwedzera vhitamini iyi kana wanga uchitora proton pump inhibitor kweanopfuura makore maviri.
Gastric acid inogona kunetsa kana isina kuvharirwa mudumbu. Nekudaro, mudumbu, iyi acidity yakakosha pakuchengeta mwero webhakitiriya wakanaka neakaipa mukutarisa. Nekuti proton pump inhibitors inodzvinyirira acidity yemudumbu, kushandiswa kwenguva yakareba kunogona kukonzera kuwanda kwebhakitiriya yakaipa, inonzi C. difficile. C. difficile chirwere chinokonzeresa manyoka, kupera mvura mumuviri, uye matambudziko akakomba kana chisina kurapwa. Naizvozvo, zvakanakisa kushandisa yakaderera dhosi uye ipfupi nguva yeproton pombi inhibitor kurapa, kunyanya mune vanonyanya kubata vanhu vakura.
Kushandiswa kwenguva refu kweproton pump inhibitors kwakaratidzirwa kuwedzera njodzi yeosteoporosis uye kuputsika kwemapfupa. Kana iwe uri pane yakakwira-dhizaini kana kwenguva refu-refu PPI kurapa, iwe unofanirwa kugara uchitariswa nekuda kwehutano hwepfupa. Vamwe vanopa vanogona kutokurudzira kukurudzira kuwedzerwa necalcium kana vhitamini D pavanotora proton pump inhibitor.
Kazhinji, kushandisa proton pump inhibitor kwemwedzi inopfuura mitatu kwakonzera kudzikira kwemazinga emagesium. Zvimwe zvakakomba zviitiko zvinogona kusanganisira kubatwa kana kunzwa kwekusajairika kwemwoyo. Kana iwe uri kutorawo diuretic, digoxin, kana mumwe mushonga uyo ungakonzere hypomagnesemia, wako mupi anogona kutora kuverenga kwekutanga kwemazinga ako emagesium kuti uchengetedze.
Chimwe chiitiko chisingawanzoitika chinosangana neyakareba-proton pombi inhibitor kushandiswa chirwere chemuviri chinonzi lupus. Kazhinji, kana lupus ikaitika ichiri kushandisa PPI, inoratidza semapundu kana maronda munzvimbo dzeganda dzinogamuchira zuva zvakanyanya uye inozivikanwa seyakatsemurwa lupus. Dzimwe nguva panogona kuve nekuita kunosanganisira muviri wese, uyo unounza nemarwadzo akabatana, mapundu, kuneta kwakanyanya, uye kupisa kwakadzika. Iyo yemuviri-yakakura reaction, inonzi systemic lupus, inogona kuitika mukati memazuva mashoma ekushandisa proton pump inhibitor. Neraki, lupus iyo inokonzeresa nekushandisa proton pombi inhibitor inowanzo gadzirisa mukati memwedzi 1-3 yekumisa mushonga.
Proton pump inhibitors inogona kudzora kushanda kwe clopidogrel, mushonga unoshandiswa kudzivirira kugwamba kweropa. Izvi zvinoitika nekuti PPIs inodzivisa enzyme inonzi CYP2C19, yakakosha pakushandura clopidogrel kune yayo inoshanda fomu. Nekuda kweiyi mukana wekudyidzana kwezvinodhaka, zvakafanira kuzivisa chiremba wako usati watanga PPI kana iwe uri kutotora clopidogrel kana zvinopesana.

Unogona here kutora proton pump inhibitors uchiine nhumbu kana kuyamwisa?

Vakadzi vane nhumbu vanofanirwa kutanga vaedza shanduko yemararamiro kugadzirisa GERD uye kubvunza vanachiremba vavo vasati vatora PPI. Nekuti mashoma emishonga iyi anogona kupinda mumukaka wemuzamu, vanaamai vanoyamwisa vanofanirwa kutaura nevanovapa hutano vasati vashandisa proton pump inhibitor.

Ko proton pump inhibitors inodzorwa zvinhu here?

Kwete, proton pump inhibitors haisi zvinhu zvinodzorwa.

Kazhinji proton pump inhibitors mhedzisiro

Proton pump pump inhibitors kazhinji inoregererwa zvakanaka. Zvisinei, kune zvimwe zvinowanzoitika mhedzisiro zvinogona kuitika, senge kutemwa nemusoro, kuzvimbirwa, manyoka, uye kushungurudza mudumbu.

Zvimwe zvakakomba mhedzisiro zvinoda kurapwa nekukurumidza zvinotevera:

Zviratidzo zvekusagadzikana (kuputika, mikoko, kunetseka kufema kana kumedza, kana kuzvimba kwemiromo, huro, kana muromo)
Zviratidzo zveakaderera magnesium mazinga (mamiriro anochinja, kurwadziwa kwemhasuru kana kushaya simba, kurwadza, kugwinha, kugwinha, kurova kwemoyo zvisina kujairika)
Shanduko mukushanda kweitsvo (kutadza kupfuudza weti, ropa murini, kana kuwedzera uremu nekukasira)
Dzungu kana kupera
Unhu kana kugwinha maoko nemakumbo
Kurwadziwa kwepfupa
Dumbu rinorwadza, rakasununguka masituru, manyoka
Kuita kwakakomba kweganda kunogona kuitika kunonzi Stevens-Johnson syndrome. Kunyangwe zvisingawanzoitika, iko kuita kwakakomba. Tsvaga rubatsiro rwekurapa nekukasira kana ukaona tsvuku, kuzvimba, kubvaruka, kana kubvisa ganda, kana maronda mumuromo mako, huro, mhino, kana maziso.

Yakawanda sei iyo proton pump inhibitors inodhura?

Proton pump pump inhibitors inowanikwa muOTC uye fomu yemishonga. Shanduro dzeOTC dzakadai se esomeprazole uye lansoprazole kazhinji haidhuri mari inodarika madhora makumi matatu pafamasi yekwako. Prescription proton pump inhibitors inowanzove yakakwira mumutengo, ichivhaira inopfuura $ 100 yekupihwa kwemwedzi kana isina kuvimbiswa. Semuenzaniso, omeprazole ndiyo yekutanga PPI kuunzwa kumusika, asi ichiri pakati pemadhora makumi mashanu pamwedzi pasina inishuwarenzi. A coupon kubva kuSingleCare inogona kudzikisa mutengo we omeprazole kuitira kuti iwe ubhadhare isingasvike $ 10 kuma pharmacies anotora chikamu. Yako inishuwarenzi inogona kunge iine zvaunofarira pane iyo proton pump inhibitors iyo yavanofukidza, saka kana sarudzo yako isiri pane formulary, gara uchitarisa neSingleCare kuti uone kuti urikubhadhara mutengo wakanyanya.