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8 maantibayoti anokonzera C.Diff

Dzidzo yehutano

Kuunzwa kwemishonga inorwisa mabhakitiriya kurapa hutachiona pasina mubvunzo kwakachinja mushonga muzana ramakore rapfuura. Asi zvimwe zvezvinoshamisa zvinodhaka, sekudanwa kwazvaimboitwa, zvinogona kusiya muviri uchinetseka kuchirwere chinotapukira chinonzi C. Difficile.

Chii chinonzi C. Diff?

Clostridioides difficile , yaimbozivikanwa se Clostridium difficile , kana C.Diff, iri hutachiona hunopararira izvo zvinogona kukonzera manyoka akakomba. Zvimwe zvakajairika C. Zviratidzo zvakasiyana zvinosanganisira fivha, kuda kurutsa, kurasikirwa nechido, uye kurwadziwa mudumbu.

Inofungidzirwa kukonzera vangangoita mazana mashanu ezviuru zvirwere muUnited States uye 15,000 kufa gore rega rega, zvinoenderana ne Nzvimbo dzekudzivirira nekudzivirira hosha . Izvozvi yakarongedzwa neCDC se Kukurumidzira Kutyisidzira - nzvimbo dzekutyisidzira dzakakwirira-kuhutano hwevanhu kubva kune utachiona hutachiona muU.S. (CDC inoronga kuburitsa chirwere yakagadziridzwa mushumo maererano neiyi data mukudonha 2019.)

Ndeapi maantibayoti anokonzera C. Diff?

Saka mashandisirwo emishonga inorwisa mabhakitiriya anoita sei kuti munhu abatwe nechirwere chinotyisa seC. Diff? Paunotora mushonga unorwisa mabhakitiriya, unoshanda kuuraya hutachiona hutachiona mumuviri wako. Mukuita izvi, iyi mishonga inogona zvakare kuparadza hutachiona hune hutano hunochengeta vanopinda saC. Diff vakatarisa. Izvo zvakakosha kuti uzive, kwete ese maantibayoti anokonzera C.Diff, uye havazi vese vane njodzi yakafanana. Kunyangwe ingangoita chero mushonga unorwisa mabhakitiriya unogona kuukonzera, honzeri yakaipa, mune iyi kesi, inowanzove yakajairika-inorwisa mabhakitiriya. Ivo vari panjodzi zvakanyanya varwere 65 kana kupfuura avo vanga vari munzvimbo yehutano, senge chipatara kana imba inochengeterwa vakwegura.

Broad-spectrum mishonga inorwisa mabhakitiriya ine zviitiko zvinopesana ne [hombe] huwandu hwehutachiona hunogara mudumbu, anotsanangura Dr. Hana Axelrod , mutevedzeri purofesa wemishonga muDanho reHosha Inotapukira ku George Washington Chikoro cheMishonga uye Hutano Sayenzi . Zvakakosha zvikuru kuva nehuwandu uye hwakasiyana huwandu hwehutachiona uhwu. Kana vanhu vakapihwa mishonga yemishonga inorwisa mabhakitiriya, ura hwavo hutachiona hunopera, nokudaro vachibvumira hutachiona, hwakadai saC.Diff, kuti igadzire kuwanda kwebhakitiriya ine hukasha inoburitsa huturu hunokanganisa ura uye hunokonzera chirwere chakanyanya.

Erika Prouty, Pharm.D., Aimbova adjunct purofesa pa Western New England University Koreji yeFarmacy muSprimfield, Massachusetts, inoipaza zvakare: Broad-spectrum maantibhakitiriya anogona kunge achityisidzira varwere nekuti ivo havangotarise mabhakitiriya akaipa isu tiri kuyedza kutsakatisa, asi zvakare anouraya akawanda mabhakitiriya akanaka ari mudumbu redu rekugaya. .

Vese Dr. Akselrod naDr Prouty vanoona clindamycin uye fluoroquinolones sevamwe vevatadzi vakaipisisa. Chinyorwa chemishonga inorwisa mabhakitiriya iyo zvinogona kukonzera C.Diff inosanganisira:

cephalosporins
clindamycin ( Cleocin )
ciprofloxacin ( Saipurasi )
kudenga ( Levaquin )
iclipusavza ( Avalox , Vigamox )
amoxillin (Amoxil)

Zvinosuruvarisa, anodaro Dr. Akselrod, nekuti mishonga inorwisa mabhakitiriya iyi iri kushandiswa zvakanyanya pazvinhu zvese kubva pamabayo kusvika kuzvirwere zvemurini. Imwe nyaya ndeye kudiwa kweimwe IV mishonga inorwisa mabhakitiriya inogara ichishandiswa navanachiremba muzvipatara zvekumusoro dzimba, idzo zvakare dzinowira pasi pemuburera wakakura. Iyi mishonga inosanganisira:

piperacillin / tazobactam (Zosyn)
meropenem (Ndinotora)

IV mishonga inorwisa mabhakitiriya inowanzoitika muE ER marongero nekuti anoshandiswa senzira yekutanga kurapwa apo varwere vanouya vachirwara uye havana chokwadi kuti chii chiri kukonzera hutachiona, anotsanangura Dr. Akselrod. Asi semunhu wezvekurapa akanyudzwa mundima iyi, anonyatsoziva nezve yakanaka mutsara vanachiremba vanofanirwa kufamba maererano neese arapa chirwere chiripo, asi asiri kuunza imwe hutachiona. Nekufamba kwenguva isu tave kuziva nezve njodzi dzinopesana nezvakanaka zverudzi urwu rwekurapa-kwese kurapa, anodaro. Inogona kunge iri foni yakaoma kuti utange IV kana kuti kwete kutanga maAV antibiotics. Chinotibatsira kuita sarudzo chaiyo inzira yekutonga uye kuyedza kuve nechakanaka chikonzero chekupa maantibioti.

Ndeapi maantibayoti asinganyanyo kukonzera C. Diff?

Kana iwe uri panjodzi huru yeC C.Diff, zvakakodzera kutaura nachiremba wako nezvekusarudza kurapwa kwakaderera. Mishonga inorwisa mabhakitiriya iri kashoma kukonzeresa C.Diff zvinosanganisira:

azithromycin ( Zithromax , Z-Pak )
chijyyyyyychiyyyyyyyyyyyyyyyyvanavana (Biaxin)
wwmira ( Oracea , Vibramycin )
erythromycin ( Eryped )
fidaxomicin ( Zvakaoma )
minocycline (Minocin, Solod )
metronidazole (Flagyl)

Ndeapi maantibayoti anorapa C. Diff?

Kunyangwe midhiya-emitambo ari pamusoro pechinyorwa cheC.Diff zvikonzero, kune mashoma marudzi e C.Diff mishonga inokwanisa kurapa hutachiona uhu. Vancomycin ndiyo inorwisa mabhakitiriya yakanyanya kushandiswa yaC.Diff, anodaro Dr. Prouty, achidudza kukosha kwemuromo, zvinopesana neIV, kurapwa: IV haina kunyatsopinza gastro-ura system, saka haina basa zvakanyanya. Uye sezvo zvese hutachiona zvichikonzerwa nehutachiona hwakasiyana (hutachiona hunokonzera chirwere), haasi maantibayoti ese ari kuenda kunongedza hutachiona uvauraye, anodaro. Naizvozvo, chaiwo madhiragi anofanirwa kushandiswa muC C. Kurapa kwakasiyana.

Izvo zvakataurwa kuti Mitengo yaC .. yakaderera mumakore achangopfuura zvishoma zvishoma nekuda kwe zvirongwa zvekubata utachiona muzvipatara, izvo zvinotsvaga kudzikisira kurayirwa kwemaantibhakitiriya asina basa. Asi kana zvasvika kune varwere vari kuita zvine mutsindo pamusoro peC.Diff kudzivirira, Dr. Akselrod anoti chinhu chekutanga chavanogona kuita kuita nhaurwa yakajeka nemubatsiri wavo wezvekurapa nezve kana vachinyatsoda mushonga iwoyo, uye kudzikisira nguva yakashandiswa pamusoro payo.