Boniva vs. Fosamax: Misiyano, kufanana, uye izvo zviri nani kwauri
Zvinodhaka Vs. ShamwariKuongorora kwemishonga & misiyano mikuru | Conditions kurapwa | Kubudirira | Inishuwarenzi kufukidza uye mutengo kuenzanisa | Zvimwe zvinokanganisa | Kubatana kwezvinodhaka | Yambiro | MIBVUNZO
Boniva neFosamax mishonga miviri yemishonga inoshandiswa mukurapa osteoporosis. Osteoporosis chirwere chemapfupa. Izvo zvinoitika kana huwandu hwemapfupa emaminetsi kana pfupa hushoma, kana kana hunhu hwepfupa hukaderera. Kana hunhu hwepfupa hukaderera, vanhu vari panjodzi yekuwedzera yekutyoka kwemapfupa, kana mapfupa akavhunika. Izvi zvinotsemuka zvinogona kusanganisira kutsemuka kwechiuno, kutsemuka kwemavara, uye kutsemuka kune iro femur uye chidya pfupa.
Pane zvinhu zvakawanda zvinogona kudzikisira mukana wako wekuvandudza osteoporosis. Izvi zvinosanganisira kugara uchirovedza muviri uye kurovedza muviri, kudzikisira kunwa doro, kurega kushandisa fodya, uye kudya chikafu chakazara muvhitamini D uye calcium. Kana chiremba wako akaona kuti iwe unoda mushonga wekurapa osteoporosis, vanogona kusarudza Boniva neFosamax, iri yekirasi yemishonga inozivikanwa se bisphosphonates. Kune dzimwe nzira dzekurapa ye osteoporosis, iyo inosanganisira Evista (raloxifene), Forteo (Teriparatide), Prolia (denosumab), calcitonin, uye estrogen kurapa.
Ndeupi mutsauko mukuru pakati peBoniva neFosamax?
Boniva (ibandronate) imishonga inonyorwa inorondedzerwa se bisphosphonate. Bisphosphonates inoshanda nekudzivirira osteoclast-mediated bone resorption. Hazvidziviriri kugadzirwa kwemapfupa. Chechipiri-chizvarwa bisphosphonates, senge Fosamax, inonyanya kuita inhibitors yeosteoclasts kupfuura yeiyo chizvarwa chekutanga, senge Didronel (etidronate). Zvimwe zvechipiri-chizvarwa bisphosphonates zvinosanganisira Actonel (risedronate), Fosamax (alendronate), Aredia (pamidronate), uye Reclast (zoledronic acid). Boniva inowanikwa mune imwechete simba piritsi yemuromo ye150 mg. Boniva muchimiro chayo chemuromo inotorwa kamwe chete pamwedzi. Boniva inowanikwawo senzira yekugadzirisa jekiseni mune 3 mg / 3 ml.
Fosamax (alendronate) imishonga inonyorwa iri zvakare yechipiri-chizvarwa bisphosphonate. Fosamax inowanikwa mumapiritsi emuromo musimba re5 mg, 10 mg, 35 mg, uye 70 mg. Inowanikwawo mune 70 mg / 75 ml mhinduro yemumuromo. Iyo 5 mg uye 10 mg doses inoitirwa kuve kamwe-zuva nezuva madosi. Iyo 35 mg uye 70 mg ingangoita-vhiki vhiki.
| Misiyano mikuru pakati peBoniva neFosamax | ||
|---|---|---|
| Boniva | Fosamax | |
| Kirasi yemishonga | Bisphosphonates | Bisphosphonates |
| Brand / generic chinzvimbo | Brand uye generic inowanikwa | Brand uye generic inowanikwa |
| Chii chinonzi generic zita? | Ibandronate | Alendronate |
| Ndeapi mafomu (s) ayo mushonga unouya? | Mahwendefa emuromo uye mhinduro yejekiseni | Mahwendefa emuromo uye mhinduro yemumuromo |
| Ndeipi muyero wakajairwa? | 150 mg kamwe pamwedzi | 70 mg kamwe kamwe pasvondo |
| Yakareba sei iyo yekurapa? | Nguva refu | Nguva refu |
| Ndiani anowanzoshandisa mushonga? | Vakuru | Vakuru |
Mamiriro ezvinhu anorapwa naBoniva naFosamax
Boniva neFosamax zvinoshandiswa mune zvese kurapa uye kudzivirira osteoporosis. Kune Fosamax, izvi zvinosanganisira postmenopausal uye corticosteroid-inosimudzira osteoporosis. Boniva inogamuchirwa kuti ishandiswe mu postmenopausal, asi kushandiswa kwayo mu corticosteroid-induced osteoporosis iri off-label. Kunze-chitupa kunoreva kushandiswa kwemushonga kuratidza kuti hauna kubvumidzwa neKudya neDrug Administration (FDA). Fosamax inogamuchirwawo mukurapa chirwere chePaget, mamiriro apo mapfupa anokura kukura uye kusimba pane zvakajairwa. Boniva inoshandiswawo nechinangwa ichi kure-chitaridzi.
| Mamiriro | Boniva | Fosamax |
| Postmenopausal osteoporosis kurapwa | Ehe | Ehe |
| Corticosteroid-inosimudzira osteoporosis kurapwa | Kunze-chitaridzi | Ehe |
| Postmenopausal osteoporosis prophylaxis | Ehe | Ehe |
| Corticosteroid-inosimudzira osteoporosis prophylaxis | Kunze-chitaridzi | Ehe |
| Chirwere chePaget | Kunze-chitaridzi | Ehe |
| Hypercalcemia yechakaipa | Kunze-chitaridzi | Kunze-chitaridzi |
| Zvakaipisisa mafupa zviitiko nekuda kwepfupa metastases | Kunze-chitaridzi | Kwete |
Boniva kana Fosamax inoshanda zvakanyanya here?
Iyo Yemwedzi Oral Therapy NeIbandronate YeOsteoporosis Kudzivirira kuyedza kudzidza, neimwe nzira inozivikanwa se MOTION muedzo , yaisanganisira vanopfuura 1,700 vakadzi vanopera kuenda kumwedzi vane makore makumi mashanu kusvika makumi masere nemasere. Chidzidzo ichi chakafananidza kamwe-pamwedzi Boniva kune kamwechete pasvondo Fosamax zvine chekuita nekukwanisa kwavo kuwedzera kuwanda kwemapfupa (BMD) pamupendero wechiuno uye muchiuno chose. Mhedzisiro yacho yakaratidza kuti kamwe chete pamwedzi Boniva haina-kuderera kune Fosamax zvine chekuita neino magumo. Iko kuderedzwa kwekudzoka kwepfupa uye gastrointestinal kushivirira zvaive zvakafanana.
Iyo Boniva Alendronate Trial muOsteoporosis, kana BALTO kuyedza , vakaongorora zvinodiwa nevarwere pakati peiyo kamwechete pasvondo Fosamax uye kamwe kamwe pamwedzi Boniva. Mhedzisiro yeiyi yakasarudzika, kuyambuka-kuyedza kwakawana kuti zvakanyanya zvakanyanya varwere vanofarira iyo kamwe pamwedzi regimen, iine 66.1% vachida Boniva zvichienzaniswa ne26.5% vachisarudza Fosamax. Izvo zvasara zvakaratidza kusafarira imwe regimen pamusoro peimwe.
Ruzivo urwu haruna kuitirwa kuraira kwekurapa. Chiremba wako chete ndiye anogona kuona kuti ndeipi nzira yekurapa inonyanya kukodzera mamiriro ako.
Kuvhavha uye mutengo kuenzanisa kweBoniva vs. Fosamax
Boniva imishonga yemishonga inowanzo kuvharwa nekutengesa uye nehurongwa hweinishuwarenzi yeMedare. Pasina inishuwarenzi, iyo kamwe chete pamwedzi regimen yaigona kukubhadharira madhora mazana maviri neshanu nemakumi masere neshanu. Uine coupon kubva kuSingleCare, generic Boniva mutengo unogona kunge wakaderera kunge $ 22.
Fosamax imushonga wemishonga unovharwa nezvose zviri zviviri zvekutengesera uye zvirongwa zveinishuwarenzi zveMedare. Kupihwa kwemwedzi mumwe kweFosamax kunogona kukubhadharira ingangoita $ 102 pasina inishuwarenzi. Iyo YegaCare koponi ye genos Fosamax inogona kudzikisira mutengo kusvika pasi pe $ 20.
| Boniva | Fosamax | |
| Kazhinji yakafukidzwa neinishuwarenzi? | Ehe | Ehe |
| Inowanzo kufukidzwa neMedare Chikamu D? | Ehe | Ehe |
| Zvakawanda | 1, 150 mg piritsi | 4, 70 mg mahwendefa |
| Chaizvoizvo Medicare copay | <$10 | <$10 |
| SingleCare mutengo | $ 22- $ 98 | $ 16- $ 39 |
Zvakajairika mhedzisiro mhedzisiro yeBoniva vs. Fosamax
Bisphosphonates vanozivikanwa neyakajairika yavo yekukonzeresa gastrointestinal mhedzisiro senge kurwadziwa kwemudumbu, kuda kurutsa, manyoka, uye kupatira. Varwere vane nhoroondo yehutachiona chirwere vanogona kunge vasina kukwikwidza bisphosphonate therapy nekuti ivo vari panjodzi huru yekuona iyi mhedzisiro pavanenge vari bisphosphonate therapy. Aya maitiro dzimwe nguva akaomarara zvakakwana kuti ade kurapwa.
Fosamax naBoniva vese vanozivikanwa nekukonzeresa musculoskeletal marwadzo mumapfupa, mhasuru, uye majoini.
Boniva yakaratidzirwa kuve yakabatana nekuwedzera kweBP pamwe nekushaya hope, kana kunetsekana kurara.
Iyi inotevera chati haina kuitirwa kuve runyorwa-rwunosanganisira rwese rwezviitiko zvakashata zvine chekuita neFosamax neBoniva. Ndokumbirawo ubvunze wako mupi wezvehutano kuti uwane runyorwa rwakakwana.
| Fosamax | Boniva | |||
| Side maitiro | Zvinoshanda? | Kakawanda | Zvinoshanda? | Kakawanda |
| Marwadzo emudumbu | Ehe | 6.6% | Ehe | 7.8% |
| Nausea | Ehe | 3.6% | Ehe | 5.1% |
| Dyspepsia | Ehe | 3.6% | Ehe | 5.6% |
| Kuzvimbirwa | Ehe | 3.1% | Ehe | 4.0% |
| Manyoka | Ehe | 3.1% | Ehe | 5.1% |
| Kubata ropa | Ehe | 2.6% | Kwete | N / A. |
| Acid kudzokorora | Ehe | 2.0% | Kwete | N / A. |
| Esophageal ulcer | Ehe | 1.5% | Kwete | N / A. |
| Kusvipa | Ehe | 1.0% | Kwete | N / A. |
| Dysphagia | Ehe | 1.0% | Kwete | N / A. |
| Kusununguka kwemukati | Ehe | 1.0% | Kwete | N / A. |
| Gastritis | Ehe | 0.5% | Ehe | piri% |
| Musculoskeletal kurwadziwa | Ehe | 4.1% | Ehe | 4.5% |
| Kutemwa nemusoro | Ehe | 2.6% | Kwete | N / A. |
| Edza kutsveyamisa | Ehe | 0.5% | Kwete | N / A. |
| Hypertension | Kwete | N / A. | Ehe | 6.3% |
| Myalgia | Kwete | N / A. | Ehe | 2.0% |
| Mapundu | Kwete | N / A. | Ehe | 2.3% |
| Kusarara | Kwete | N / A. | Ehe | 2.0% |
Kwayaka: Fosamax ( Zuva Nezuva Boniva ( Zuva Nezuva )
Kusangana kwezvinodhaka zveBoniva vs. Fosamax
Kana Boniva neFosamax vakapihwa calcium ine zvinowedzera kana maantacid, iyo calcium inogona kukanganisa kupinza kweFosamax. Vazhinji osteoporosis varwere vanofanirwa kutora calcium supplement, saka zvinokurudzirwa kuti umirire maminetsi makumi matatu mushure mekutora Fosamax kutora calcium kana chero mimwe mishonga yemumuromo.
Nonsteroidal anti-anogumbura zvinodhaka (NSAIDs) zvinosanganisirwa pachezvadzo nemudumbu mativi mhedzisiro akafanana ne bisphosphonates. Hazvikurudzirwi kutora mwero isingachinjiki yeNSAIDs uchitora bisphosphonates.
Pane humwe humbowo hwekuti kupa bisphosphonates neH2-blockers, chimiro chedumbu acid chinodzora chinoshandiswa kurapa kuputika kwechirwere, kunowedzera kuwanikwa kweiyo bisphosphonate drug.
Iyi chati haina kunyora kwese kusangana kunozivikanwa kwezvinodhaka. Ndokumbirawo ubvunze wezvehutano nezvezita rakazara.
| Zvinodhaka | Kirasi yemishonga | Fosamax | Boniva |
| Calcium Aluminium Magnesium Iron | Multivalent cation inowedzera uye maantacid | Ehe | Ehe |
| Aspirin Ibuprofen Naproxen Diclofenac Ketorolac Meloxicam Celecoxib | Nonsteroidal Anti-anogumbura Mishonga (NSAIDS) | Ehe | Ehe |
| Famotidine Ranitidine | H2-blockers | Ehe | Ehe |
Yambiro dzeBoniva neFosamax
Kubvisa mazino panguva yekurapa bisphosphonate kunogona kuwedzera njodzi yekuvandudza osteonecrosis yesaya (ONJ), kana kufa zvishoma nezvishoma kwejaya. Usati watanga bisphosphonate therapy, varwere vanofanirwa kuongororwa mazino uye vafunge kuita chero ekudzivirira kana kugadzirisa maitiro emazino vasati vatanga kurapwa.
Varwere vane mamiriro epo esophageal akadai seBarrett's esophagus, dysphagia, kana ulcers vanogona kuita kuti mamiriro avo awedzere kuwedzera ne bisphosphonates. Nekuda kwetsika yavo yekukonzera kutsamwa kune mucosa yegapu, bisphosphonates inofanira kutorwa chinhu chekutanga mangwanani negirazi diki remvura. Mimwe mishonga, zvinwiwa, uye chikafu zvinofanirwa kudzivirirwa kwemaminitsi makumi matatu, asi zvakaringana kwemaawa maviri. Varwere vanofanirwa kuramba vakamira kwemaminitsi makumi matatu mushure mekutora yavo dosi. Havafanirwe kurara pasi. Aya matanho anodzivirira esophageal kutsamwa.
Varwere vane yakaderera calcium mazinga, kana hypocalcemia, vanofanirwa kutora matanho anodiwa ekugadzirisa iwo calcium mazinga vasati vatanga bisphosphonate therapy. Varwere vanogona kuenderera necalcium therapy kana vatanga bisphosphonates chero bedzi vachitevera iwo marongero ekuparadzanisa yavo calcium dosi kubva kune bisphosphonate.
Fosamax neBoniva dzinofanirwa kushandiswa nekuchenjerera kune varwere vane hutachiona hwehutachiona kana chirwere cheitsvo. Renal basa rinofanira kuongororwa nekuti rakadzikira renal basa zvinoreva kuti hauzokwanise kujekesa mushonga kubva mumuviri wako nemazvo uye mushonga unogona kuwanda mumuviri wako.
Inowanzo bvunzwa mibvunzo nezve Boniva vs. Fosamax
Chii chinonzi Boniva?
Boniva mushonga wekunyorerwa mukirasi inonzi bisphosphonates. Iyo inoshandiswa kurapa uye kudzivirira osteoporosis. Boniva inowanikwa seyakagadziriswa mushonga uye kamwechete pamwedzi piritsi.
Chii chinonzi Fosamax?
Fosamax zvakare iri mishonga yemishonga mukirasi yemishonga inozivikanwa se bisphosphonates. Inoshandiswa pakurapa nekudzivirira osteoporosis. Fosamax inowanikwa mune kamwe chete zuva nezuva mahwendefa emuromo, kamwechete vhiki nevhiki mahwendefa emuromo, uye mhinduro yemuromo.
Boniva naFosamax zvakafanana here?
Boniva neFosamax ndivo vechipiri-chizvarwa bisphosphonates, asi iwo haana kunyatso kufanana. Musiyano wavo mukuru ndewekuti vanoiswa sei. Boniva inogona kupihwa kamwe pamwedzi, nepo Fosamax inogona kupihwa kamwe zuva nezuva kana kamwe chete pasvondo.
Boniva kana Fosamax iri nani here?
Zvidzidzo zvakaratidza Boniva neFosamax kuva nemhedzisiro yakafanana yekiriniki maererano nehutano hwepfupa, zvisinei, ongororo imwechete yakaratidza kuti ruzhinji rwevarwere vanofarira iyo kamwe pamwedzi dosing regimen yeBoniva.
Ndinogona here kushandisa Boniva kana Fosamax ndichiri nepamuviri?
Kunyange Boniva kana Fosamax havana kudzidza mune vakadzi vane nhumbu. Kushandisa kwavo kunofanirwa kudzivirirwa mumadzimai ane pamuviri kudzivirira kukuvara kune fetus.
Ndinogona here kushandisa Boniva kana Fosamax nedoro?
Doro uye zvese zvinwiwa zvinofanirwa kudzivirirwa kwenguva yakati mushure mekutora Boniva kana Fosamax kudzivirira kutsamwa kwesophageal. Kunyatsonwa doro kunosanganisirwa nenjodzi dzakakwira dze osteoporosis, uye nekudaro izano rakanaka kudzora kunwa.
Ndeupi mushonga wakachengeteka uye wakachengeteka we osteoporosis?
Iyo National Osteoporosis Nheyo inopa nhungamiro yekurapa osteoporosis. Bisphosphonates senge Fosamax, Boniva, Reclast, uye Actonel inoonekwa seyekutanga-mishonga yekurapa pamwe nezvimwe zvinokurudzirwa senge calcium supplementation uye kurovedza muviri.
Boniva inowedzera kuwedzera kwemapfupa here?
Boniva inosanganisirwa nekuwedzera kwakakosha mu bone bone density (BMD). Izvi zvinoderedza njodzi yekutyoka mune osteoporosis varwere.
Unofanira here kutora calcium neBoniva?
Iwe haufanire kutora calcium panguva imwechete seBoniva, asi iwe unogona kutora calcium yekurasikirwa kwepfupa iwe uri paBoniva kurapwa. Iwe unofanirwa kumirira kwemaminitsi makumi matatu mushure meiyo bisphosphonate dose usati watora yako calcium yekuwedzera.
