Chii chinoitika mukati memuviri wako kana iwe ukatora mushonga?

Zvinodhaka Info

Medza piritsi, mira zvishoma, unzwe zvirinani-zvakapusa, handiti? Kwete chaizvo.

Ndeipi nzira yeADME?

Rwendo rwemushonga nemuviri wako - chirango mukati mefarmasi inonzi pharmacokinetics - hachisi chinhu chiri nyore. Kubva panguva iyo mushonga unopinda mumuviri wako kusvika panguva yaunosiya, zvakawanda zvinoitika. Masayendisiti akadana maitiro aya ADME, ipfupi yekumwa, kugovera, metabolism uye, pakupedzisira, kuburitsa. Asi sei, chaizvo, mushonga unobva panzvimbo A (kutora) kunongedza E (excretion)? Takabvunza nyanzvi.

Kubvisa

Kubvisa kunoenderana zvakanyanya nehurongwa hwekutakura mushonga. Majekiseni anopfuura chikamu chekutora nekuti anoendeswa akananga muropa. Asi mishonga yakawanda yatinotora kumba iri mupiritsi kana fomu remubhadharo, uye ayo anoda kupinzwa mudumbu kana mudumbu (gut). Mukutaura kwesainzi, mushonga unodikanwa kuti usungunuke usati wawana mukana wekutenderera kweropa.

Inonzwika yakatwasuka, asi, sezvinhu zvakawanda mumushonga, hazvisi. Iyo acidity yemudumbu uye mudumbu, pamwe nekugadzirwa kwemushonga pachawo, zvinogona kukanganisa kunwa. Ditto yeiyo mafiringi uye machira anoshandiswa mukugadzira kwemushonga.

Dumbu rine acidic nharaunda, anotsanangura Colin Campbell, Ph.D., anoshamwaridzana purofesa wefarmacology ku Yunivhesiti yeMinnesota Medical Chikoro muMinneapolis. Yatinoti isina simba asidi mishonga, seaspirini, yakanyatso nyudzwa ipapo. Asi isina simba base drug, se morphine, ine kunonoka kunonoka nekuti, kunze kwekunge yapihwa nejekiseni, inofanirwa kubva kune yakakwira-acid nharaunda yemudumbu kuenda kunzvimbo isina kwayakarerekera yematumbo yekumwa.

Kugoverwa

Mushure mekunge mushonga wawana mukana muropa, iro ropa rinorigovera kumatishu emuviri.

Kuti zvinoitika sei zvinoenderana zvakanyanya nezvinodhaka zvemushonga.

Semuenzaniso, zvinodhaka zvinogadziriswa nemafuta (senge zvideo , steroid inoshandiswa kurapa kuzvimba) tsvaga mafuta maseru kwaanonyungudika nyore nyore uye nekupfuura nepama cell cell. Mvura inogadziriswa nemvura, yakadai se atenolol , yaishandiswa kurapa BP, kunamira muropa uye mvura inoyerera yakatenderedza masero.

Chimwe chinhu chinokanganisa kugovaniswa ndechekuti mushonga unogadzirwa nemamorekuru mahombe kana madiki. Mazhinji mishonga inoshandiswa kurapa madiki mamorekuru madhiragi- uye nechikonzero chakanaka. Madiki mamorekuru madhiragi, senge Nexium (yaishandiswa kurapa gastroesophageal Reflux chirwere), kupfuura nyore kuburikidza nesero membranes kuti vagone kuenderera nerwendo. Makuru mamorekuru madhiragi, senge insulin, ane nguva yakaoma yekuzadza membrane uye anonyanya kupihwa nejekiseni.

Metabolism

Metabolism, inonziwo biotransformation, inowanzoitika muchiropa.

Panguva yekugovera, mushonga unotakurwa uchienda kuchiropa kuburikidza neyakaitika maitiro kana nerubatsiro rwevanonzi vatakuri varipo pamasero enhengo. Ma enzymes akasarudzika ari muchiropa makemikari anoshandura mushonga uye nekuushandura kuita chimiro chinogona kuburitswa zviri nyore.

Asi pane kubata. Nyaya dzinokanganisa chiropa dzinogona kukanganisa kuti mushonga unodonha nekukurumidza zvakadii. Cirrhosis (kana kuora kwechiropa), semuenzaniso, zvinogona kuita kuti zviome kuti mushonga uiswe muviri, uchirega uchigara mumuviri kwenguva refu. Mishonga mishoma inogadziriswa muitsvo zvakare.

Uye mimwe mishonga inogona kumisa ma enzymes kana anotakura zvinhu, anodaro Joseph Grillo, Pharm.D., Director director wekunyora uye kutaurirana kwehutano muHofisi yeClinical Pharmacology kuFDA. Izvi zvinogona kukonzeresa kuti mushonga unosara mumuviri kwenguva yakareba uye muhuwandu hwakawanda kupfuura hunodikanwa, uchiwedzera mikana yehuturu, anodaro.

Excretion

Excretion ndiyo nzira iyo muviri unobvisa pachako mushonga, uye ndizvo zvinonyanya kugadziriswa neitsvo uye weti yavanogadzira. Kana mushonga usingasvinwe nyore neitsvo, dzimwe nguva inogona kuchinjwa nechiropa kuitira kuti zvisaririra zvipfuure nemurini. Mishonga isingakwanise kusefedzwa neitsvo inopfuura nemu biliary ducts iri muchiropa uye ichisiya muviri nenzira yemutsvina.

Beyond ADME: Izvo iwe zvaunoda kuti uzive

Zvakawanda zvinhu zvinokanganisa maitiro anoita muviri wako mushonga. Kune kutanga, pane:

• Zera . Nhengo dzechikuru hadzishande nemazvo sevadiki, zvinoreva nzira iyo chiropa chako, dumbu, kana itsvo zvakagadziriswa mushonga pa25 zvakasiyana pane pamakore makumi matanhatu nemashanu. Huwandu hwezvinodhaka zvinotorwa nevanhu vakuru zvinogona kukanganisa maitiro acho.
• Gender . Nekuti isu takasiyana muhuremu hwemuviri, mafuta, huwandu hwemvura yemuviri, kuyerera kweropa kunhengo uye mahormone mazinga, ADME inogona kuve yakasiyana muvarume nevakadzi.
• Zviri mudumbu . Hapana hombe yekuvhundutsa pano ― iyo cheeseburger uye fries iwe wawakadya mushure mekutora yako mushonga zvinogona kudzora rwendo rwechirwere. Zvizhinji zvekudya zviri nani kunyura kuburikidza nematumbu, anodaro Campbell. Asi dumbu rakazara rinononoka kutora uye kutora mushonga kwenguva yakareba kuti uende kune yemudumbu system. Kune rimwe divi, mimwe mishonga inofanirwa kutorwa nechikafu chekunyorova zviri nani.

Pazasi mutsara? Tevedza mafambiro. Verenga tsamba yekunyorera yebhodhoro uye chero chinhu chakaiswa zvakanyatsonaka, uye bvunza mibvunzo kana uchida kujekeswa, Dr. Grillo anodaro.