Izvo vabereki vanofanirwa kuziva nezve Reye's syndrome

Dzidzo yehutano

Chii chinonzi Reye's syndrome? | Zviratidzo | Kuongorora | Kurapa | Kudzivirira

Kana iwe uri mubereki, iwe unogona kuziva kuti haufanire kumbopa aspirin kumwana ane huku yekuhukura kana dzihwa. Chikonzero cheichi ndechekuderedza njodzi yemamiriro ezvinhu akakomba uye chirwere chinogona kuuraya chinonzi Reye's syndrome, kana Reye syndrome, iyo inogona kukonzera chiropa kusagadzikana uye kuzvimba muuropi uye yakabatanidzwa nekushandiswa kweaspirini muvana nevechidiki vane hutachiona. hutachiona senge furuwenza, varicella (iyo inokonzera chickenpox), yepamusoro yekufema nzira dzekutapukisa, uye COVID-19, iyo inokonzereswa nerinova coronavirus.

Muna 1980, iyo Centers for Disease Control uye Kudzivirira (CDC) yakanyora 555 kesi dze Reye chirwere muUnited States. Neraki, gore rimwe chetero yambiro dzakapararira nezvekushandisa maaspirin kwevana dzakatanga , uye kubva muna 1994 nyaya dzisingasviki mbiri dzakashumwa gore rega rega munyika yose.

Mumakore makumi masere, mwana mumwe chete pavana zviuru zana akaiwana - izvozvi, anenge mumwe mumiriyoni, anodaro Amy Cram, MD, chiremba wevana ane Maodzanyemba Ekurapa Boka . Izvi zvinonyanya nekuti isu tinoziva kuti kushandisa asipurini sechinhu chinodzora kupisa kana kupisa-kupisa kunowedzera njodzi.

Vazhinji vana (vangangoita makumi masere muzana) vanowana Reye's syndrome vanopona, asi inoda kurapwa nekukasira, kazhinji muchipatara chevanorwarisa. Kana ikasarapwa, Reye's syndrome inogona kutungamira mukukuvara kwehuropi zvachose kana kufa mumazuva mashoma chete.

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Chii chinonzi Reye's syndrome?

Reye's syndrome chirwere chinowanzo kuwanikwa muvana nevechiri kuyaruka vari pasi pemakore gumi nemasere- kazhinji avo vane makore 4 kusvika 12 -Asi inogona kubata vanhu vezera ripi zvaro. Vanachiremba havazivi chaizvo zvinokonzeresa Reye's syndrome, asi inogara ichitevera chimwe chirwere uye inowanzo kuve yakabatana nekushandiswa kwemishonga ine aspirin muvana vane hutachiona hwehutachiona.

Aspirin, inozivikanwawo seacetylsalicylic acid, salicylic acid, kana acetylsalicylate, ndiyo yakanyanya-kushandiswa kurwadziwa-kurerutsa mushonga munhoroondo . Inoshanda nekudzivirira kugadzirwa kwemuviri weprostaglandins, inova michina inogadzirwa nema enzymes mumuviri anoita basa rakakosha mukupindura kwemuviri kuputira kana kukuvara.

Kana ichishandiswa kuhutachiona hutachiona, aspirin inogona kukanganisa mitochondria yemunhu, inova zvidiki zvidiki mumasero anonzi anounza simba rekumhanyisa sero.

Aspirin mukumisikidza kwehutachiona hutachiona, senge furuwenza kana huku, inokonzeresa kukuvara kwechiropa mitochondrial, anodaro Nathan Chishanu, Pharm.D., Wemishonga ane Kroger . Uye izvi zvinokonzera kusagadzikana kwechiropa.

Uku kusagadzikana kwemitochondrial kunogona kutungamira kune yakawanda ammonia -chigadzirwa che metabolism - muropa. Aya mamiriro, anonzi hyperammonemia, anogona kukonzeresa kuzvimba muuropi uye nekuwedzera kumanikidza pauropi painodzvinyirira dehenya. Kuwanda kwekuzvimba uye kumanikidza kunoona kuomarara kwezviratidzo zvemunhu zveeurologic.

Reye's syndrome zviratidzo

Kunyangwe ichikanganisa nhengo dzese dzemuviri, Reye's syndrome ndiyo inonyanya kukuvadza huropi nechiropa. Ndicho chikonzero, mune zvekurapa, zvinotsanangurwa se: acute noninfigueatory encephalopathy ine mafuta chiropa kutadza. Encephalopathy, mamiriro anochinja mashandiro ehuropi kana chimiro, ndicho chiratidzo chinotyisa cheReye's syndrome, asi zvakaoma kwazvo kuziva kusvikira kukuvara kwatoitwa kuuropi uye zviratidzo zvechirwere zvoonekwa.

Zviratidzo zvinowanzoonekwa mazuva matatu kusvika mashanu mushure mekutanga kwehutachiona hwehutachiona uye kazhinji zvinotanga nekukasira, kuramba uchirutsa, kunyangwe muvana vari pasi pemakore maviri ekuberekwa, chiratidzo chekutanga chinogona kunge chiri manyoka . Kurutsa kunowanzo teverwa nekuwedzera kuneta kana kurara zvisina kujairika; zvisinei, vana vari pasi pemwedzi gumi nemiviri vanogona kuuya vasina kurutsa. Zviratidzo zveNeurologic zvinotanga kuoneka mukati maawa makumi maviri nemana kusvika makumi mana anotevera uye zvinogona kusanganisira:

• kugumbuka
• kusagadzikana
• kunyongana
• hunhu hunochinja
• kutadza kuyeuka

Sezvo chirwere ichi chichienderera mberi nekukurumidza uye huropi huchienderera kudzikira nekuda kwekuzvimba uye kumanikidza, zvimwe zviratidzo zvinogona kusanganisira:

• vakawedzeredzwa vadzidzi
• kuvhiringidzika kana kusagadzikana
• kuona zvisipo
• kufema zvakadzama kana kukurumidza
• kukurumidza kurova kwemoyo
• kurasikirwa kwekuziva

Pamusoro pezviratidzo zveeurologic, Reye's syndrome inogona zvakare kukonzera kuwanda kwemafuta muchiropa uye nedzimwe nhengo. Kuomarara kwezviratidzo uye kufungidzira kwekupora kunosiyana siyana uye zvinoenderana nekuwanda kwekukuvara kwakaitwa kuuropi. Vamwe vanhu vane zviratidzo zvakapfava uye vanozorora zvizere Vamwe vanosara vaine hurema hwakati kuti hwepfungwa kana hwepanyama.

Muzviitiko zvakakomba, kukuvara kwehuropi kunogona kutungamira mukugwinha, kuoma mitezo mumaoko nemakumbo, pakoma, uye pakupedzisira kufa. Iyo kufa kwehuwandu hweReye's syndrome yaimbove ne50%, asi iyo nhamba yaderera kusvika pasi pe20% mumakore apfuura.

Reye's syndrome inoonekwa sei?

Kuongororwa kwekutanga uye kurapwa kwakakosha zvakanyanya neReye's syndrome, saka chero vacheche, mwana, kana wechidiki uyo achangobva kuve nehutachiona hwehutachiona uye anoratidza chero zviratidzo zveReye's syndrome zvinofanirwa kuendeswa kuchipatara emergency chipinda nekukurumidza sezvazvinogona. Kuti uwane kuongororwa kwakakodzera, zvakakosha kuti vanochengeta vape nhoroondo yezvekurapa zvese mishonga, kusanganisira pamusoro-the-counter, zvinowedzera, uye mavitamini, izvo zvakatorwa nemurwere.

Kuongororwa kunowanzo kutanga nekuongororwa kweropa uye weti kuongorora kuti uone zvinhu zvakaita semafuta-asidi akakwira kana mazinga eammonia muropa. Chiropa chemistry bvunzo, kunyanya, inogona kubatsira. Mhedzisiro yacho inogona kunge yakagadzirira mukati memaawa mashoma, uye bvunzo dzinogona kuona mazinga akakwirisa emamwe maenzymes eropa-muropa. Huwandu hwepamusoro hweaya maenzyme chiratidzo chingangoitika cheReye's syndrome.

Zvimwe zvinetswa zvinoverengeka zvinogona kukonzera zviratidzo zvakafanana neReye's syndrome, saka chikamu chekuongororwa chichava nekutonga kunze kwemamiriro akaita se:

• fatty-acid oxidation kusagadzikana uye zvimwe zvechiropa zvinoshanda nyaya
• zvikanganiso zvekuzvarwa zvemetabolism uye mamwe matambudziko emagetsi
• kushandisa zvinodhaka, kumedza, kana kuratidzwa kune chepfu
• hutachiona hwehutachiona hwehutachiona hwakadai se encephalitis (kuputika kweuropi) uye meningitis (kuputika kwemakumbo ekudzivirira akapoteredza uropi nemutsipa wepelinha)
• chirwere chepfungwa

Mune zvimwe zviitiko, pombi yemuzongoza inogona kuitwa kuti uone kuwanda kwekumanikidza mumuviri wecebrospinal fluid (CSF). Mune maitiro aya, anonziwo lumbar puncture, tsono inoiswa kuburikidza nechezasi kumashure kune imwe nzvimbo padivi nepamuviri mbichana, uye shoma CSF inobviswa kuyedzwa. Kuwedzera kwekumanikidza kwekumanikidza kunogonawo dzimwe nguva kuonekwa nemagineti resonance imaging (MRI) kana yekomputa tomography (CT) scan, uye vanachiremba vanogona kuraira imwe yeiyi bvunzo pakuongorora chikonzero.

Reye's syndrome kurapwa

Kurapa kweReye's syndrome kunofanira kutanga nekukurumidza sezvinobvira kubatsira kunonoka kufambira mberi kwechirwere.

Panguva iyo vana vane Reye's syndrome [kana mwana ane chero chirwere] vane shanduko muhunhu hwavo hwepfungwa (danho ravo rekusvinura nekuziva), vanofanirwa kuenda kuimba yekukurumidzira, Dr. Cram anodaro. Uye zvino vangangopedzisira vari munzvimbo yevanonyanya kutarisirwa vachitariswa uye kugadzikana nekutenderera-kwe-wachi.

Iko hakuna mushonga weReye's syndrome, saka kurapwa kunoitirwa kuchengetedza huropi kubva kune kumwe kukuvara, kuyedza kudzoreredza zvinhu zvemetabolism izvo zviri kukonzera uropi kuzvimba, kuve nechokwadi kuti mapapu anoramba achishanda kuburikidza nenzira senge yekufema chubhu kana mweya, uye kuderedza kushushikana kwese kwemuviri kunogona kudzora kusungwa kwemoyo.

Iwe unogona kushandisa mweya wekufema mweya kune mumwe munhu ane Reye's syndrome, iyo inogona kubatsira nekuzvimba kwehuropi, Dr. Cram anodaro. Kune zvakare mishonga (senge mannitol kana dexamethasone ) iwe unogona kuvapa izvo zvinogona kubatsira nekuzvimba.

Kurapa kunogona kubatsira kunonoka kufambira mberi kweReye's syndrome, uye zvinyoro kesi zvisingaenderere mberi zvinogona kukonzera kusagadzikana kwenguva refu.

Nzira yekudzivirira Reye's syndrome

1. Zvinodhaka zvekudzivirira (kuwedzera kune aspirin)

Zvinogona kunge zvisingaite kudzivirira zviitiko zvese zveReye's syndrome, sezvo zvimwe zviitiko zvisina kubatana neaspirin. Zvisinei, mikana yekubatira chirwere ichi chisingawanzoitika inoderera zvakanyanya nekuona kuti vana vane hutachiona hutachiona havatore chero mishonga ine acetylsalicylic acid, salicylic acid, acetylsalicylate, kana salicylate compounds. Pamusoro peaspirini, izvi zvinosanganisira izvi zvinopfuura-izvo-zvinodhaka:

• Alka-Seltzer
• Anacin
• Ascriptin
• Bufferin
• Doan's
• Ecotrin
• Excedrin
• Kaopectate
• Maalox
• Pamprin
• Pepto-Bismol

Ichi hachisi chinyorwa chakazara. Taura nemubatsiri wevana vako kana wemishonga kuti uwane rumwe ruzivo. Izvo zvakakosha vabereki nevachiri kuyaruka verenga zvese zvinyorwa zvemamwe ma-counter mishonga usati wavatora.

2. Kubaya majekiseni

Kunze kwekudzivirira iyo mishonga, unogona kudzikisa njodzi yemwana wako yekutapukirwa nehutachiona munzvimbo yekutanga nekudzivirira vana vako pazvirwere zvese zvinodzivirirwa, asi kunyanya furuwenza (kana furuwenza) kana varicella (chickenpox) sezvo izvi zviri zviviri anowanzozivikanwa majekiseni-anodzivirirwa febrile zvirwere. Vana vanogamuchira varicella majekiseni pamakore gumi nemaviri nemakore mana uye vanofanirwa kuwana mushonga wefuru gore rega.

3. Marwadzo akachengeteka anodzora uye anodzora fivha

Kunze kweiyo isina-aspirin mutemo vana vane mamiriro anopindura zvakanaka kurapwa kweaspirin, senge chirwere cheKawasaki. Mune zviitiko izvi, vabereki vanofanirwa kubvunza chiremba vasati vapa kurwadziwa-kuuraya kana anti-kupisa mishonga. Kune vamwe vana, acetaminophen (Tylenol) kana ibuprofen (Motrin) inogara ichikurudzirwa panzvimbo peaspirini, kunyanya nezvirwere zvehutachiona.